Insulin Responses Ratio (IRR) Test for Hyperinsinism Modification and Diabetes Reversal

Majid Ali, M.D.

An Article of Dr. Ali’s Course on Diabetes Reversal With Insulin Detox Series


I coined the term “insulin response ratio” (IRR) for the numerical value of the ratio between the blood insulin concentrations obtained after the standard 75-gram glucose challenge and a non-carbohydrate load containing an equivalent caloric load (300 calories). The IRR number gives the patient an objective, quantifiable, and modifiable value which provides most revealing insights into insulin homeostasis of the patient when starting a program of insulin reduction or diabetes reversal.


Diabetes Reversal With Insulin Detox (A Primer Book)  

This book is available by calling 212-873-2444 or 973-586-4111.


Reversing hyperinsulinism and diabetes type 2, first and foremost, is a matter of philosophy—a philosophy of life and a philosophy of nutrition. Paths of philosophy cannot be sought by counting calories and reading about glycemic indices of foods or glycemic load. Such studies have their place in learning. I have not seen them make the real difference. The IRR test is valuable to employ interim insulin testing to delineate the patient’s metabolic responses to fats, proteins, and carbohydrates in the diet.

As for counting calories, calories in food items is not the issue in insulin reduction and reversal of diabetes. The crucial issue is how different foods in different combinations evoke different insulin responses. Here I do not refer to food grouping based on blood groups or on fats, proteins, and carbohydrates. Next, knowledge of glycemic indices of foods and their glycemic loads tells us nothing about what we really need to know: how the metabolic pathways of an individual with hyperinsulinism and/or diabetes respond to meals.


Reversing hyperinsulinism and diabetes type 2 with dietary, detox, and lifestyle changes usually takes several months. During this period of time, it is necessary to have some yardsticks about the starting point and the finish line, to use some sports language. It is valuable to employ interim insulin testing to delineate the patient’s metabolic responses to fats, proteins, and carbohydrates in the diet. This is where I find the IRR test results most revealing and patient compliance-enhancing.

The issue of gentle daily bowel-blood-liver detox is crucial for reversing hyperinsulinism and diabetes type 2, but is addressed in other articles in my free course entitled “Dr. Ali’s Diabetes Course.”


Laboratory Insulin Profiling for IRR Test

I assess the effectiveness of my integrative plan with the following “Three-Step-Insulin-Testing” approach:

A. A 3-hour insulin and glucose profile following a standard glucose load before beginning the program

B. Fasting and one-hour post protein and fat food load insulin and glucose profile (a protein powder, lecithin, ground flaxseed, and organic vegetable juice are used for this purpose). Please Google “Dr. Ali’s Breakfast” for details.

C. A 3-hour insulin and glucose profile following a standard glucose load one year after beginning the program.


Insulin and Glucose Profiles With IRD Values

Tables 1-3 present insulin and glucose profiles of three patients with rising IRR values. The differences between IRR values of patients without diabetes (Tables 1 and 2) and the one with diabetes (Table 3) are notable.


Table 1. Insulin and Glucose Profiles With IRD Value of 2.5. The Patient, A 52 Year-Old 5′ 2″ Woman Weighing 228 Lbs, Presented With Recurrent Sinusitis, Hypothyroidism , Chronic Fatigue, And Urtricaria

7/10/13

Fasting

½ HR

1 HR

2 HRS

3 HRS

Insulin

6

50

50

10

Glucose

85

92

87

52

Insulin and Glucose Responses to a 300-Calorie Non-Carbohydrate Load

1/30/14

Fasting

½ HR

1 HR

2 HRS

3 HRS

Insulin

14

20

Glucose

97

83

Table 2. Insulin and Glucose Profiles With IRD Value of 3.3. The Patient, A 71 Year-Old 5’2″ Woman Weighing 175 Lbs. Presented With Rapid Weight Gain, Hypothyriodism, and Prehypertension.

5/16/13

Fasting

½ HR

1 HR

2 HRS

3 HRS

Insulin

5.8

54.6

60.1

36.3

5.3

Glucose

87

145

91

76

51

Insulin and Glucose Responses to a 300-Calorie Non-Carbohydrate Load

6/21/13

Fasting

Insulin

4.73

17.7

Glucose

98

98

Insulin

Glucose

Fasting

½ HR

1 HR

2 HRS

3 HRS

Insulin

Glucose

END

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