Oxygen and the Diabetes-Tuberculosis Connection

Majid Ali, M.D.

Diabetes, at its core, is a disease of impaired oxygen signaling. Tuberculosis, at its core, is a disease of impaired oxygen signaling. From this, it should be self-evident that diabetes and tuberculosis will mutually fan each other’ fires.

I explains the scientific basis of the above statements about the core of diabetes and TB in my Oxygen Model of Diabetes and Oxygen Model of Tuberculosis summarized at the end of this article.


The Diabetes-Tuberculosis Connections

Diabetes triples the risk of developing tuberculosis. It has been known for centuries that diabetes weakens the immune system and it is much more difficult for diabetics to eradicate infections than people with the disease. On October 31, 2014, the journal Science reported that one of every three individuals worldwide live with the microbe that causes a latent form of tuberculosis. The journal warned against this “looming co-epidemic” and asked for research to clarify the “murky” diabetes-TB link.


Nothing Murky About the Diabetes-TB Link

I assert that there is nothing murky about the diabetes-TB link (see below brief outline of my Oxygen Model of Co-Morbidity). Still I laud the Science’s call for more research. It will undoubtedly come up with yet additional evidence for the disease-infection connection.


The Oxygen Models of Co-Morbidity

The Oxygen Model of Co-Morbidity is an extension of my Oxygen Model of Health and Disease. It is a unifying model that explain all aspects of the two disorders existing as a co-morbidity—clinical course, consequences, and control—on the basis of disturbed oxygen function. The most important among these compromised and/or blocked functions are: (1) oxygen signaling; (2) oxygen’s ATP energy generation; (3) oxygen’s detergent functions; (4) oxygen’s cellular detox functions; (5) oxygen-regulated cell membrane and matrix functions; (6) oxygen’s cellular repair roles.

All these factors involved in one of the two disorders in any specific co-morbidity state will fan the fires of the other. Furthermore, the clinico-pathologic consequences of each disease in the co-morbidity state with intensify the degree of the other.

The Oxygen Model of Co-Morbidity provides a simple model that allows physicians to reduce complexities of diverse clinical syndromes into a workable simplicity. This model predicts that ongoing research will reveal that components of acidosis (excess acidity), oxidosis (increased oxidative stress), and CUD (clotting-unclotting dysequilibrium) will be found to play important roles in the pathology and clinical features of preeclamsia and autism. .

The crucial importance of the Unifying Oxygen Model of Co-Morbidity is that it:

1.Explain the scientific basis of primary mechanism of cellular energetic dysfunction in the two disorders;

2. Shed light how health can be restored by addressing all relevant oxygen-related issues;

3. Elucidate how toxicities of foods, environments, and thoughts cause tissue injury and disease; 4. Reveal the mechanisms by which various detox therapies work (Oxygen is the primal detergent which removes cellular grease and allows cells to breathe freely).

4. Allow the formulation of rational and effective designs for preventing, arresting, and reversing these disorder; and

5. Provide explanations of mechanisms by which time-honored natural remedies work.


Suggested Additional Readings

* Dr. Ali’s Oxygen Model of Diabetes

* Dr. Ali’s Oxygen Model of Infectious Diseases

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