Importance of the Oxygen Model of Co-Morbidity For Treating Diabetes

Majid Ali, M.D.

Insulin toxicity (hyperinsulinism) predates diabetes by five to ten or more years. This fact is universally accepted. Yet, insulin profiling is not done in nearly all patients to prevent the development of diabetes. In this “latent diabetes” period, insulin toxicity leads to weight gain, fatigue, skin pigmentation, dryness of skin, nerve irritation, fatty liver, and related conditions.


In 1958, I was taught that all features of all diseases can be seen in diabetes mellitus. I accepted this statement uncritically. At time, oxygen never entered the discourse except when a patient was near death and had to be administered nasal oxygen. It would be my oxygen eureka about twenty years later that revealed to me altogether new dimensions and clinical implication of that statement. Now to the subject of oxygen in holism in integrative medicine. 


The Oxygen Model of Co-Morbidity in Treating Diabetes is an extension of my Oxygen Model of Health and Disease. It is a unifying model that explain all aspects of the two disorders existing as a co-morbidity—clinical course, consequences, and control—on the basis of disturbed oxygen function. The most important among these compromised and/or blocked functions are: (1) oxygen signaling; (2) oxygen’s ATP energy generation; (3) oxygen’s detergent functions; (4) oxygen’s cellular detox functions; (5) oxygen-regulated cell membrane and matrix functions; (6) oxygen’s cellular repair roles.


All the above factors involved in one of the two disorders in any specific co-morbidity state will fan the fires of the other. Furthermore, the clinico-pathologic consequences of each disease in the co-morbidity state with intensify the degree of the other.


The Oxygen Model of Co-Morbidity provides a simple model that allows physicians to reduce complexities of diverse clinical syndromes into a workable simplicity. This model predicts that ongoing research will reveal that components of acidosis (excess acidity), oxidosis (increased oxidative stress), and CUD (clotting-unclotting dysequilibrium) will be found to play important roles in the pathology and clinical features of preeclamsia and autism.


The crucial importance of the Unifying Oxygen Model of Co-Morbidity in Treating Diabetes is that it:

1. Explains the scientific basis of primary mechanism of cellular energetic dysfunction in the two disorders;

2. Shed light how health can be restored by addressing all relevant oxygen-related issues;

3. Elucidate how toxicities of foods, environments, and thoughts cause tissue injury and disease;

4. Reveal the mechanisms by which various detox therapies work (Oxygen is the primal detergent which removes cellular grease and allows cells to breathe freely).

5. Allow the formulation of rational and effective designs for preventing, arresting, and reversing these disorder;

6. Provide explanations of mechanisms by which time-honored natural remedies work; and

7. Most importantly from a clinical standpoint, all therapies used for arresting or reversing one disorder in the co-morbidity state will have the benefits of arresting or reversing the other disease, so fostering holism in integrative medicine.

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