A Picture Story of Diabetes

Majid Ali, M.D.

Blood Cells Tell the Full Diabetes Story

For Children and Their Grown-up Children


Insulin toxicity predates diabetes type 2 for a variable number of years. It generates excess acidity and free radical activity in the circulating blood, and thickens it. By these effects it damages blood cell membranes, clumps cells, forms crystals of acids, and weakens immune and hunter cells of the blood. In this article, the blood and its cells tell the diabetes story.


I hope parents will study the microscopic pictures in this article, understanding their meanings, and then study them again with their children to teach them the dangers of eating excess sugary drinks and foods.

These pictures make it easy to learn and understand how diabetes causes poor circulation, heart attacks, and stroke. —for prevention and reversal—more simply and elegantly than any medical textbook or a doctor. Of course, cells can tell their diabetes story only to those who are willing to listen to them. We cannot understand the “cell-speak” if we keep repeating that diabetes is a sugar problem. Sugar is not a cell nor is diabetes cells. Nor can we communicate with cells if our focus is on excess insulin or insulin resistance.

Blood Cells Tell the Cell Membrane Story

Cell membranes exist to separate internal order of cells from their external disorder. They are responsible for cellular cross-talk. So, the health and strength of cells in all parts of the body depend on the the health and strength of their membranes. There are no lab tests available at this time for directly assessing the structural and functional integrity cell membrane in the pancreas (the source of insulin), liver, heart, brain, kidneys, muscles, and other body organs. The state of blood cell membranes, easily evaluated by direct microscopic examination of the blood, provides useful information, albeit indirect, about cell membranes in other body organs. Blood cells tell the story of cell membranes in all organs in the body. body I elaborate this crucial point by presenting the case of insulin and insulin receptor protein embedded in cell membranes.

The Crank and Crank-Shaft Model of Diabetes
At the cell membrane level, diabetes develops when insulin fails to move (activate) insulin receptor protein embedded in the membrane.  The blood cells  assessing cell membrane practical results The cell membranes become resistant to insulin when they become chemicalized—plasticized, so to speak—and hardened, immobilizing the insulin receptors embedded in the membranes. The insulin receptor is a protein that criss-crosses the cell membrane like a cord. One of the consequences of grease buildup on cell membranes is that insulin receptor becomes turned and twisted, literally and figuratively. In a previous paper, I offered the analogy of a crank and a crank-shaft to explain insulin resistance. I visualize insulin as a crank—a device that transmits rotary motion—and the insulin receptor protein as a crank-shaft embedded in the cell membrane.receptor protein as a crank-shaft embedded in the cell membranes.


In this series of articles and the companion radio and TV series on the subject, I will explain and illustrate how the following four blood cell types tell the full diabetes story:

Red Blood Cells of a Healthy Person
(upper picture)

Early Stress on Red Blood Cells (lower picture)


When Hunter Blood Cells Become the Hunted, and the Hunted Microbes become the Hunters
Large Deposits of Crystals of Acids in the Circulating Blood of a Patient With Uncontrolled Diabetess

Beginning of Heart Disease
Micro-plaque Formation

 

Beginning of Heart Disease
Micro-plaque Formation

 

Blood

Beginning of Heart Disease
Micro-plaque Formation

 

Figure 1 

Normal microscopic appearance of cardiac myocytes (heart muscle cells). Note the branching and merging of individual myocytes with dark rectangular and elongatednuclei. The matrix between them is delicate and contains smaller and thinner nuclei.  

Figure 2

An early stage of cardiac cell death (cardiac myocytolysis). The arrows point to a disintegrating cell.

Figure 3

An intermediate stage of cardiac myocytolysis (muscle cell death with focal disintegration of myocytes (center field)

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