Autoimmune Neutropenia: Granuloma Annulaire or Insulin Toxicity

Majid Ali, M.D.


Skin lesion on the back of 13-year-old girl with autoimmune neutropenia which was considered to be granuloma annulaire (see the photograph below). The cause of this skin lesion is considered unknown.


autoimmune NeutroGranulom


Salient lab Test Results

(which had not been done by the patient immunologist and pediatrician)

* Impaired Krebs Cycle

* Large amounts of mold toxins in 24-hour urine sample

* Mold and pollen allergy

* Hyperinsulinism (insulin toxicity)


Insulin Toxicity or Granuloma Annulaire

The patient had elevated blood levels of insulin. I have seen similar skin lesion with areas of pigmentation and depigmentation in many in insulin-toxic individuals. Note the areas of skin pigmentation changes in areas above the lesion diagnosed as granuloma annulaire.

Microscopic features of both conditions can be similar.


Question:

When the cause of one specific skin lesion is clear known (insulin toxicity) and that of the other considered “unknown,” which diagnosis is makes more sense?

The insulin is easy to define and correct, while there is no known-cause-dirrecyted treatment of granuloma annulaire.


The young girl is feeling better with nutritional therapies and control of bowel fermentation.


Celiac Disease

She was also diagnosed with celiac disease. I have seen all symptom-complexes of celiac disease created by gut fermentation.

Another Crucial Point

The young lady had no previous history of wheat intolerance. So much for celiac disease!

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