Basics of Insulin Connections

Majid Ali, M.D.


What Is Insulin Intelligence

I introduce term Insulin Intelligence for a clear working understanding of molecular biology of insulin which is necessary for preventing and reversing diabetes of all types. Specifically, it includes a deep knowledge of energetic, metabolic, signaling and other functions of insulin. To foster Insulin Intelligence, I include in this article brief outlines of Oxygen Model of Insulin Toxicity and The Crank-Crank-Shaft Model of Insulin Dysfunction. Before that, below in the simplest possible words, I offer the core of my dietary guidelines for normalizing insulin homeostasis.

1. Insulin in excess (insulin toxicity) is fattening and inflaming.

2. Healthy fats are insulin-friendly.

3. Healthy proteins are insulin-friendly.

4. All breads, pastas, fruits and fruit juices, and sugars are insulin-unfriendly.

5. Vegetables are insulin-friendly.


The Crank-Crank-Shaft Model of Insulin Dysfunction

In my book entitled “Dr. Ali’s Plan for Reversing Diabetes,” I illustrated the insulin/insulin receptor dysfunction with a crank/crank-shaft analogy. Below is some text from that book (available at www.aliacademy.org http://www.majidali.com).

The cell membranes become resistant to insulin when they become chemicalizedplasticized, so to speakand hardened, immobilizing the insulin receptors embedded in the membranes. The insulin receptor is a protein that criss-crosses the cell membrane like a cord. One of the consequences of grease buildup on cell membranes is that insulin receptor becomes turned and twisted, literally and figuratively. In a previous paper, I offered the analogy of a crank and a crank-shaft to explain insulin resistance. I visualize insulin as a cranka device that transmits rotary motionand the insulin receptor protein as a crank-shaft embedded in the cell membrane.receptor protein as a crank-shaft embedded in the cell membranes.


Insulin Signaling

Insulin serves myriad metabolic, vascular, and signaling roles, including:

1. Facilitation of the entry of glucose in cells;

2. The breakdown of glucose to produce energy in cells;

3. Storage of glucose in the liver;

4. Conversion of glucose into fatty acids;

5. Activation of specific enzymes involved with protein metabolism; and

6. Changes in vascular reactivity (compliance).


My Oxygen Model of Diabetes

My Oxygen Model of Diabetes is a unifying model that explains all aspects of diabetes Types 1 and 2—causes, clinical course, consequences, and control—on the basis of impaired oxygen signaling, diminished oxygen’s detergent functions, and interrupted oxygen’s cellular detox and repair functions. I put forth this model first in a series of articles in 2000 and presented it at length it in my book “Dr. Ali’s Plan for Reversing Diabetes (2006)” (available for download at www.aliacademy.org)


Two Examples of Ideal Insulin Profiles

Table 1. Ideal Insulin Profile (Peak Value, 18 uIU/mL) of a 60-yr-old 5′ 7″ Male Film-maker weighing 147 lbs. Without Health Problems and Interested in Healthfl Aging. His Three “Secrets to Health” Are: Beautiful Thoughts, Diet, and Exercise.”

6.8.2013

Fasting

1/2 Hr

1 Hr

2 Hr

3 Hr

Insulin

<2

18

14

4

<2

Glucose

77

168

109

74

52

Table 2. Ideal Insulin Profile of a 51-year-old 5’2″ Woman Weighing 120 lbs. She Consulted Me for Hypothyroidism and Allergy.

Fasting

½ Hr

1 Hr

2 Hr

3 Hr

4 Hr

Insulin

3.2

11.8

2.4

1.9

1.5

Glucose

85

110

75

70

52

91


Table 3. 54 yr-old 5′ 11″ Man weighing 265 lbs. Presenting With BP (185/120 down to 120/80 with Breathing, Alleregy, Steatosis, Hepatomegaly, BPH, A1c 5.1% on 4.5.2013

2. 2.2013

Fasting

½ Hr

1 hr

2 Hr

3 Hr

Insulin

24.3

52.1

69.1

119

38.4

Glucose

106

165

193

205

80

April 4, 2013 Post Dr. Ali’s Breakfast

Insulin

6.9

14.9

Glucose

70

146

August 30, 2013 Weight constant at 196

Insulin

2.96

31.2

20

14.8

Glucose

70

146

148

138



Two xamples of Ideal  Insulin Profiles

Table 1. Ideal Insulin Profile (Peak Value, 18 uIU/mL) of a 60-yr-old 5′ 7″ Male Film-maker weighing 147 lbs. Without Health Problems and Interested in Healthfl Aging. His Three “Secrets to Health” Are: Beautiful Thoughts, Diet, and Exercise.”

6.8.2013

Fasting

1/2 Hr

1 Hr

2 Hr

3 Hr

Insulin

<2

18

14

4

<2

Glucose

77

168

109

74

52

Table 2. Ideal Insulin Profile of a 51-year-old 5’2″ Woman Weighing 120 lbs. She Consulted Me for Hypothyroidism and Allergy.

Fasting

½ Hr

1 Hr

2 Hr

3 Hr

4 Hr

Insulin

3.2

11.8

2.4

1.9

1.5

Glucose

85

110

75

70

52

91

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