Insulin Toxicity And Liver Disease (Non-specific Parenchyma Liver Disease)


Majid Ali, M.D.

A Revealing Insulin Story

In good health, men have peak insulin level of less than 25 units in a three-hour test. I saw a man in his 60s with a peak level of 191 units, which indicates severe insulin toxicity (hyperinulinism). This degree of insulin toxicity, in my insulin files, is associated with liver injury in all cases. One of his blood tests for liver health done by his primary doctor was abnormal, indicating liver inflammation. I pointed this out to him. He was surprised and disappointed. Next I read the report of his liver ultrasound and found the words “non-specific parenchyma liver disease.” I mentioned that to him and that stressed him further.

“I have liver disease and my doctor did not tell me that,” he growled.

“Let’s look at the glucose results,” I said.

“But that’s not right,” he persisted.

“Let’s look at the glucose results,” I repeated gently.

“What is my sugar result?” he suppressed his frustration.

“Your peak glucose level if 239.”

“What doesn’t that mean? A touch of diabetes.”

“It means diabetes and it is reversible,” I said reassuringly.

“And the liver disease?”

“That too. When we get rid of insulin toxicity, the liver will become healthy.”

Non-specific Parenchyma Liver Disease

Words matter. What does the term non-specific parenchyma liver disease mean to a pathologist? It means liver inflammation of unknown cause. How can any form of tissue injury be treated optimally if the cause is unknown? The term insulin toxicity, by contrast, is a specific term which reveals the true nature of the tissue injury with clearly definable and modifiable marker. The success in treatment, or absence of it, can be measured precisely with insulin testing.

The Lesson

I consider insulin profiling as the most important tests for all adults and overweight children. Both the liver disease and diabetes in this case were the result of insulin toxicity, which remained undetected because insulin tests were not done.

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