How Does Metformin Work?

Majid Ali, M.D.

Metformin Is An Excellent Diabetes Drug When It Is Really Needed


Metformin Use During Diabetes Reversal

The right treatment of diabetes Type 2 associated with insulin toxicity (hyperinsulinism) is reversal of diabetes with a diet-detox-divinity program (see my book entitled ‘Dr. Ali’s Plan for Reversing Diabetes (2011) available at http://www.aliacademy.org). At the time of initial diagnosis,

Metformin (Glucophage) is my preferred drug for treating diabetes Type 2 during the process of reversal of diabetes with integrative non-drug plan. However, at the time of initial diagnosis, some phramcologic support is sometimes necessary. This is where Metformin has merit.


Metformin was first derived from French lilac (also called goat rue). As a herbal remedy, it has been used for more than 500 years. It has many important effects. The best characterized of these effects are:

  1. Slows down oxygen-governed mitochondrial function
  2. Reduces oxidative stress by altering cellular oxidant-antioxidant equilibrium
  3. Reduces glucose production
  4. Reduces blood glucose level
  5. Lowers blood insulin concentration
  6. Inhibits NF-kB (an essential mediator of inflammation)
  7. Reduces insulin-like growth factor 1 (IGF-1)

My FREE Courses

  1. Dr. Ali’s Diabetes Course
  2. Dr. Ali’s Insulin Course
  3. Dr. Ali’s Oxygen Course

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