What Are Insulin Signals?

Majid Ali, M.D.

What Do Insulin Signals Do?


Insulin has crucial roles in the metabolism, cellular growth and replication, and vascular functions. These roles are served by the ability of insulin to send “signals” for cellular responses. Salient insulin signals preserve health by:

☞ Facilitation of the entry of glucose in cells;
☞ The breakdown of glucose to produce energy in cells;
☞ Storage of glucose (as glycogen) in the liver;
☞ Storage of fat in the fatty tissues;
☞ Conversion of glucose into fatty acids;
☞ Activation of specific enzymes involved with protein metabolism;
☞ Changes in vascular reactivity (compliance); and
☞ Management of energy reserves in the body.


Insulin awakens (activates) insulin receptors embedded in the cell membranes and leads to activation of internal cellular mechanisms involving a host of cellular proteins, such as glucose transporters. Insulin affects all cell populations of the body. However, the fats cells (lipocytes) and muscle cells (myocytes) are the two types that are most potently influenced by insulin. The fat cells store excess food energy for future needs, while the muscle cells are essential for all movements, such as breathing, heartbeats, circulation of the blood, and contractions in the alimentary tract. Together, the fat and muscle cells account for approximately two-thirds of all human cells.

In the minds of the doctors and the public, insulin is “good.” A lack of insulin causes diabetes. Injections of insulin save lives. Such simplistic thinking is the single most important impediment to clear thinking about the nature of diabetes and intelligent designs for its prevention and treatment. The dichotomy of healer-killer roles of insulin is seldom, if ever, fully appreciated by doctors. The reason for this is that doctors, with rare exceptions, do not test for defects in the fundamental cellular energetics. The possibility of de-diabetization, of course, is always rejected by diabetologists. Such superficial approach shifts the focus away from the crucial subject of insulin toxicity, a severe state that can be readily recognized with appropriate laboratory tests.


Science, Health, and Healing Video Encyclopedia

Insulin toxicity is inflaming and fattening. It damages all cellular populations in the body. It sets the stage for obesity, pre-diabetes, and diabetes with all its complication. For these and other reasons, I offer a channel of close to 75 videos on the subject on my YouTube Science, Health, and Healing Encyclopedia. I invite readers to consider it as a source of information.


Insulin Institute Website

Nearly all subjects listed above are also presented on my website titled http://www.insulininstitute.org. For more information on the various aspects of insulin toxicity, I refer the reader to this source of insulin. Here is a simple question to vet your appetite: What is prediabetes? The answer: insulin toxicity. Here is another question: What is diabetes Type 2 for most people in the first five to ten years of their illness? The answer: insulin toxicity. If you are puzzled by my answers and really want to be knowledgeable about the subject, read everything on www.insulininstitute.org.

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