REVERSING DIABETES – LESSON TWO

Majid Ali, M.D.

Insulin-Wise Living, Insulin-Smart Eating for Reversing Diabetes

Celebrating Small Successes, Not Sweating Small Missteps


What Is Insulin?

It is a hormone produced by pancreas, a gland located behind the stomach which lowers the blood glucose level by driving glucose into the cells.


 

How Does Insulin Work?

Insulin hormone preserves health in many ways. Specifically, its metabolic, energy-regulating, vascular, growth-maitaining, and diverse other effects include:

1. Facilitation of entry of glucose into cells.

2. Breakdown of glucose to produce ATP energy.

3. Storage of energy into the liver and muscles.

4. Conversion of glucose into fats and proteins.

5. Serve as a signaling molecule for multiple growth reactions.


How Does Insulin Toxicity Develop?

The Crank-Crank Shift Model of Insulin Toxicity

 In my book entitled “Dr. Ali’s Plan for Reversing Diabetes,” I illustrated the insulin/insulin receptor dysfunction with a crank/crank-shaft analogy. Below is some text from that book (available at http://www.majidali.com).
The cell membranes become resistant to insulin when they become chemicalized—plasticized, so to speak—and hardened, immobilizing the insulin receptors embedded in the membranes. The insulin receptor is a protein that criss-crosses the cell membrane like a cord. One of the consequences of grease buildup on cell membranes is that insulin receptor becomes turned and twisted, literally and figuratively. In a previous paper, I offered the analogy of a crank and a crank-shaft to explain insulin resistance. I visualize insulin as a crank—a device that transmits rotary motion—and the insulin receptor protein as a crank-shaft embedded in the cell membrane.receptor protein as a crank-shaft embedded in the cell membranes.



Or, the Insulin Lock and Insulin Key Model of Insulin Toxicity, if you so prefer.

 


Is hyperinsulinism the same state as insulin toxicity?

Yes. I coin the term insulin toxicity to replace hyperinsulinism because it tells the story well, while most people do not know what blood insulin level does hyperinsulinism begin.


How Do I Become Insulin-wise and Live a Healthy Life?

Read, read, and read about insulin, health, and healing until you love reading about it.  


 

Some Crucial Questions

* How much time do you spend talking about insulin with your patients?

* For chronic ailments, I talk about oxygen and insulin, and then about the bowel and the liver.

* How about spirituality?

As soon as I think the patients is ready for it. Spiritual openness is what matters most, but most patients want to talk about their diseases first.

* You say diabetes is an insulin problem, not and a sugar problem. What do you really mean by this?

  1. Diabetes is not a sugar problem
  2. Two examples of healthy insulin and glucose (sugar) profiles
  3. One example of insulin and glucose profiles of an individual with diabetes, before and after diabetes reversal
  4. What is insulin intelligence
  5. Metabolic Actions of Insulin Hormone
  6. How does insulin toxicity (hyperinsulinism) develop)?
  7. Oxygen Model of Insulin Toxicity

Why Is It Important Not to Consider Diabetes to Be a Sugar Problem?

Diabetes is not a sugar problem. Diabetes can neither be prevented nor reversed by focusing on blood glucose (sugar) levels. To reverse diabetes, we need “Insulin Intelligence,”which requires the study of the subject with healing literacy, not with disease literacy or drug literacy.

Please study Table 3 for the insulin and glucose profiles of the man who reversed diabetes by making his insulin work. Closely examine his falling insulin level accompanied by his falling blood glucose levels with passing months. But first for comparison study, I offer two ideal insulin profiles presented in Tables 1 and 2.


 

What Is A1c Test?

It is a blood test which indicates the average of blood glucose levels for about 90 days before the blood sample is drawn.

In my experience, A1c test is not reliable for screening for diabetes, nor for insulin toxicity. It is a good test for knowing how effective the treatment for diabetes and/or  insulin toxicity is.

An A1c value of 5.5% indicated excellent blood glucose levels. A value of 6 means poor control of diabetes. A value of 6.5 means very poor control A value of ten means an urgent need for improved treatment. I consider values of 12 and over to indicate medical emergencies.


Is Fasting Blood Glucose Level a Good Screening Test for diabetes?

No. I have seen this test to unreliable in too many cases. I have seen patient with diabetes show a fasting blood glucose level of less than 95, which is considered negative for the disease. I have also seen patient who had fasting glucoe level of over 100 who did not have diabetes when a full 3-hour test was done.


At What Blood Glucose Level Is Diabetes Diagnosed?

When the blood glucose level is 200 or over in the 2-hr blood sample drawn following a test load of 75 grams of glucose taken by mouth (as a syrup.


At What Blood Glucose Level Is Prediabetes Diagnosed?

When the blood glucose level is 200 or over in the 1-hr blood sample drawn following a test load of 75 grams of glucose taken by mouth (as a syrup.


Welcome to My videos Series

https://player.vimeo.com/video/96150106

Seed, Feed, and Weed for Bowel Health Part One from Majid Ali on Vimeo.


Seed, Feed, and Weed for Bowel Health Part Two from Majid Ali on Vimeo.


Seed, Feed, and Weed for Bowel Health Part Three  – Microbiome and Doctors from Majid Ali on Vimeo.



 To Be Insulin-Wise, One Must First Be Bowel-Wise. 

The Seed-Feed-and-Occasionally-Weed-Way to Reverse Chronic Inflammatory, Immune, and Infectious Diseases

Seeding is the repopulation of the gut with microflora that have been destroyed by indiscriminate use of antibiotics or crowded out by the unrestrained proliferation of yeast and bacterial organisms such as the Proteus and Pseudomonas species. The “guardian angel bacteria” for bowel ecology belong to the Bifidobacterium and Lactobacillus species. Some other species also play protective roles. In health, these organisms provide the necessary counterbalance to the growth of yeast and pathogenic bacterial organisms. Beyond this, these organisms produce several molecules that play critical roles in our molecular defense systems.

Feeding is the use of some growth factors that the normal bowel flora require to flourish. These include biotin, pantetheine, Vitamin B12 and others. We clinicians have used Vitamin B12 for decades with good clinical results (to the great chagrin of those “academicians” who considered it quackery because they couldn’t understand how this vitamin could ever help anybody except those with pernicious anemia). One of the principal mechanisms by which vitamin B12 exerts its myriad beneficial effects is by serving as a “growth hormone” for health-preserving bowel flora. Of course, this vitamin has several other essential roles. It plays a role in the citric acid cycle (the main molecular pathway for energy generation where it facilitates the conversion of methylmalonyl-CoA to succinyl-CoA) and is essential for cell maturation. Further, Vitamin B12 benefits many patients with neuropsychiatric disorders unassociated with anemia or macrocytosis (N Eng J Med 318:1720; 1988).

Occasional weeding is the use of several natural substances that are known to suppress the overgrowth of pathogenic bacteria, viruses and yeasts. During initial treatment, I frequently use oral nystatin or fluoconazole (Diflucan) for short periods of two to three weeks, partly for diagnostic and partly for therapeutic reasons (how a person with one of the ABE states responds to these agents is useful in assessing the degree of damage to bowel ecology). Extensive clinical experience has convinced me that long-term clinical results are far superior when the use of drugs is kept to a minimum.

 


 Saving Insulin By Making Insulin Work

 

 

Examples of Insulin Detox

Table 1. Ideal Insulin Profile (Peak Value, 18 uIU/mL) of a 60-yr-old 5′ 7″ Male Film-maker weighing 147 lbs. Without Health Problems and Interested in Healthfl Aging. His Three “Secrets to Health” Are: Beautiful Thoughts, Diet, and Exercise.”

Table 1. Ideal Insulin Profile (Peak Value, 18 uIU/mL) of a 60-yr-old 5′ 7″ Male Film-maker weighing 147 lbs. Without Health Problems and Interested in Healthfl Aging. His Three “Secrets to Health” Are: Beautiful Thoughts, Diet, and Exercise.”
6.8.2013 Fasting 1/2 Hr 1 Hr 2 Hr 3 Hr
Insulin <2 18 14 4 <2
Glucose 77 168 109 74 52
Table 2. Ideal Insulin Profile of a 51-year-old 5’2″ Woman Weighing 120 lbs. She Consulted Me for Hypothyroidism and Allergy.
Fasting ½ Hr 1 Hr 2 Hr 3 Hr
Insulin 3.2 11.8 2.4 1.9
Glucose 85 110 75 70 52

 

An Example of Reversing Diabetes

Table 3. 54 yr-old 5′ 11″ Man weighing 265 lbs. Presenting With BP (185/120 down to 120/80 with Breathing, Allergy, Steatosis, Hepatomegaly, BPH, A1c 5.1% on 4.5.2013
2. 2.2013 Fasting ½ Hr 1 hr 2 Hr 3 Hr
Insulin 24.3 52.1 69.1 119 38.4
Glucose 106 165 193 205 80
April 4, 2013 Post Dr. Ali’s Breakfast
Insulin 6.9 14.9
Glucose 70 146
August 30, 2013 Weight constant at 196
Insulin 2.96 31.2 20 14.8
Glucose 70 146 148 138

 


WELCOME! The Crank-Crank Shift Model of Insulin Toxicity

 In my book entitled “Dr. Ali’s Plan for Reversing Diabetes,” I illustrated the insulin/insulin receptor dysfunction with a crank/crank-shaft analogy. Below is some text from that book (available at http://www.majidali.com).
The cell membranes become resistant to insulin when they become chemicalized—plasticized, so to speak—and hardened, immobilizing the insulin receptors embedded in the membranes. The insulin receptor is a protein that criss-crosses the cell membrane like a cord. One of the consequences of grease buildup on cell membranes is that insulin receptor becomes turned and twisted, literally and figuratively. In a previous paper, I offered the analogy of a crank and a crank-shaft to explain insulin resistance. I visualize insulin as a crank—a device that transmits rotary motion—and the insulin receptor protein as a crank-shaft embedded in the cell membrane.receptor protein as a crank-shaft embedded in the cell membranes.




WELCOME! Metabolic Actions of Insulin Hormone

 Insulin hormone preserves health in many ways. Specifically, it has metabolic, vascular, and signaling roles, including:

☞ Facilitation of the entry of glucose in cells;

☞ The breakdown of glucose to produce energy in cells;

☞ Storage of glucose in the liver;

☞ Conversion of glucose into fatty acids;

☞ Activation of specific enzymes involved with protein metabolism; and

☞ Changes in vascular reactivity (compliance).




 Insulin-Wise Living With Insulin Intelligence ELCOME! 

I introduce term Insulin Intelligence for a clear working understanding of molecular biology of insulin which is necessary for preventing and reversing diabetes of all types. Specifically, it includes a deep knowledge of energetic, metabolic, signaling and other functions of insulin. To foster Insulin Intelligence, I include in this article brief outlines of Oxygen Model of Insulin Toxicity and The Crank-Crank-Shaft Model of Insulin Dysfunction. Before that, below in the simplest possible words, I offer the core of my dietary guidelines for normalizing insulin homeostasis.


Insulin-Wise Eating 

Five Things to Remember

  1. Sugar in any form increases insulin toxicity
  2. Healthy fats are insulin-friendly.
  3. Healthy proteins are insulin-friendly.
  4. All carbohydrates in excess are insulin unfriendly.
  5. Vegetables are insulin-friendly.


  6. Insulin in excess (insulin toxicity) is fattening and inflaming.

 

W Oxygen Models of Insulin Toxicity and Diabetes Type 2 

I proposed my Oxygen Models of Insulin Toxicity and Diabetes as unifying models that recognize disturbances of oxygen functions as the fundamental commonality of all elements that cause dysfunctional insulin signaling, hyperinsulinism (excess insulin), insulin resistance (inability of the insulin receptor to respond to insulin), and the biochemical and clinical consequences of insulin dysfunction.


Models in Science Are Proposed to: 

  1. Offer workable simplicity to reduce complexities of natural phenomena;
  2. Explain such phenomena;
  3. Predict natural phenomena hitherto unrecognized.

 

Models in medicine are tested, validated, or refuted with ongoing scientific observation. In clinical medicine, I add a fourth criterion for a model’s validity: it must facilitate health and healing. 
How does my Oxygen Model of Insulin Toxicity stand up to these criteria? I leave that to the readers’ faculty of considering the evidence which I present in a large series of my articles on http/:VUIM.org and in my insulin channels on my YouTube Science, Health, and Healing Encyclopedia. 




Seven Simple Lessons for Reversing Diabetes 

 

Reversing Diabetes – Seven Simple Lessonshttps://alidiabetes.org/2015/12/06/diabetes-prevention-and-reversal-seven-simple-lessons/

Insulin-Smart Recipes

https://alidiabetes.org/2016/07/25/recipes-for-insulin-detox-and-diabetes-reversal/


 

Insulin Video Series

Dr. ALI’S 3-PART DIABETES COURSE – PART THREE

https://alidiabetes.org/2016/07/25/dr-alis-3-part-diabetes-course-part-three/

Dr. ALI’S 3-PART DIABETES COURSE PART TWO

https://alidiabetes.org/2016/07/11/dr-alis-diabetes-course-part-two/


Link to Library of Recipes for Reversing Diabetes and Insulin Detox 

https://alidiabetes.org/2016/07/25/recipes-for-insulin-detox-and-diabetes-reversal/


Videos and Read More on Reversing Diabetes At This Web Site. Use the search box to access Diabetes Course.


Who Is Doctor Ali? 

https://vimeo.com/100034154


 

List of Recipies and Other Related Articles

Dr. Ali’s Breakfasts

Dr. Ali’s Yogurt Breakfast

* Dr. Ali’s Omelette Breakfasts

Dr. Ali’s Protein Shake Breakfast

 Dr. Ali’s Breakfast Shake 3-4 Days a Week

*  Dr. Ali’s Weight Loss Breakfast

*  Dr. Ali’s Line of Omelettes for Weight Loss and Aging Healthfully

* Dr. Ali’s Spicy Omelette

Dr. Ali’s Weight Loss, Anti-diabetes Spicy Yogurt

 Saying NO to Fat-free Yogurt, Please!

Dr. Ali’s Omelette Recipes An Introduction

Dr. Ali’s Omelette Recipes

* Dr. Ali’s Insulin-Wise Breakfast

* Dr. Ali’s Insulin-Wise Lunch Recipes

* Dr. Ali’s Breakfast 3-4 Days a Week

Dr. Ali’s Flax and Chia Seeds Omelete

* Dr. Ali’s Ginger – Walnut Omelette

Dr. Ali’s Edamame Omelette

* Dr. Ali’s Sesame Omelette

Dr. Ali’s Garlic Omelette

* Dr. Ali’s Onion Omelette

Dr. Ali’s Insulin-Wise Pink Dal (Lentil) Lunch Recipe

* Dr. Ali’s Black dal (lentil) Lunch Recipe

Dr. Ali’s Insulin-Wise Flax and Chia Seeds Omelette

*  Dr. Ali’s Insulin-Wise Tuna-Tiki Recipe

*  Dr. Ali’s Insulin-Smart Palak-Tiki Recipe

*  Dr. Ali’s Vege-Tiki Recipe

k  Insulin-Wise Foods, Insulin-Saving Recipes

k  Dr. Ali’s Insulin-Wise Breakfast – Personalized

k  Insulin-saving Almond snack

k  Dr. Ali’s Insulin-Wise Pink Dal (Lentil) Lunch Recipe

k  Dr. Ali’s Black dal (lentil) Lunch Recipe

Foods

*  Dr. Ali’s Recipes

Butter Is Good, Butter Is Bad, Butter Is Good

 Eggs Are Good, Eggs Are Bad, Eggs Are Good Again

Grains

Gluten Sensitivity

Gluten-free Foods

 

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