Molecular Biology of Insulin Course

Majid Ali, M.D.

Molecular Biology of Insulin

I present diverse aspects of molecular biology of insulin in my FREE Dr. Ali’s Course on Diabetes and Dr. Ali’s Course on Molecular Biology of Insulin posted at this site.

Seven Stages of Insulin Toxicity | The Ali Academy Community

Apr 30, 2011 – Majid Ali, M.D. In matters of life span, I summarize the lessons learned … with knowing the fundamentals of the molecular biology of insulin, …

insulin toxicity seven stages | The Ali Academy Community

Apr 30, 2011 – Posts about insulin toxicity seven stages written by majidalimd. … Majid Ali, M.D. In matters of life span, I summarize the lessons learned from … addressed with knowing the fundamentals of the molecular biology of insulin, a.

S even Stages of Insulin Toxicity – Dr. Ali’s Virtual Medical Library

Majid Ali, M.D … knowing the fundamentals of the molecular biology of insulin, a subject that is sadly and regularly neglected in the prevailing model of medicine.

Molecular Biology of Oxygen | Ali Academy

Jan 6, 2016 – Posts about Molecular Biology of Oxygen written by Majid Ali MD. … term “pre-Alzheimer’s” to refer to state of insulin toxicity (hyperinsulinism) …

Molecular Biology of Oxygen -Oxygen Homeostasis … – Who Is Dr. Ali?

Dec 21, 2015 – Majid Ali, M.D. Dr. Ali’s Molecular Biology of Oxygen Course Full texts of these … Ali M. Oxygen, Insulin Toxicity, Inflammation, And the Clinical …

Dr. Ali’s Insulin-Based Diabetes Reversal Plan | Ali Diabetes

Jun 26, 2016 – Molecular Biology of Oxygen; Insulin homeostasis. Study of insulin toxicity ….. The Oxygen Model of Insulin Toxicity – Majid Ali, M.D. | The Ali …

Insulin-Sugar Choice

Majid Ali, M.D. … We can keep insulin low and have less diabetes, heart disease, stroke, and cancer. … In the following years I published several articles and some books to the study of molecular biology ofoxygen (over 100 on my essays on …

Dysox Model of Diabetes and De-Diabetization Potential (May 2007 …

by Majid Ali, MD … The abnormalities of insulin functions are the consequences of plasticized …. Much-needed light on the genetics of diabetes is also shed by newer data ….. Dr. Ali’s breakfast on five to six days per week comprising:

Books by Majid Ali, MD

I discuss this subject and related oxygen matters at length in my Molecular Biology of Oxygen Course posted on this site and on

Reporting a comment for the article : Acetate mediates a microbiome … › Journal home › Archive › Authors

Jun 9, 2016 – Majid Ali said: … sugar-adducts, and increased molecular debris), which immobilizes the insulin … (6) chronic stress; and (7) other elements related to molecular biology of oxygen. … Ali M. Altered States of Bowel Ecology. 3.



Below is the abstract of an important paper on the subject:

Muller-Wieland D, at al. Molecular biology of insulin receptor. Exp Clin Endocrinology. 1993;101:17-29.


Insulin resistance is an essential feature of a great variety of clinical disorders, like diabetes mellitus, obesity, essential hypertension, and is primarily due to a defect in hormone action at the cellular level. In the past decade application of novel research techniques including recombinant DNA technology have paved the way to understand the mechanisms of insulin action and its alterations at the molecular level. The first step in insulin action is the activation of the insulin receptor. The insulin receptor is a tetrameric protein consisting of two extracellular alpha- and two transmembrane beta-subunits. Binding of insulin to the alpha-subunit causes autophosphorylation of the intracellular beta-subunit region on tyrosine residues thereby activating the receptor. How the hormonal signal is subsequently transduced within the cell is still quiet unclear. The activated insulin receptor appears to couple to cytosolic receptor substrates which can affect different signaling cascades eliciting the pleiotropic hormone response on cell metabolism and growth. Most proteins involved in the signal transduction pathway of insulin are not known yet, but each of them might play a role in the various forms of insulin resistance. Taking the insulin receptor as an exemplary protein involved in insulin action we review molecular mechanisms regulating insulin receptor activity, gene expression, and the role of natural occurring insulin receptor gene mutations in patients with insulin resistant diabetes mellitus. It is outlined how the combination of both clinical medicine and molecular biology not only helps to understand insulin action and the pathogenesis of insulin resistance, but also leads to new avenues in the differential diagnosis, therapy, and possibly prevention of this heterogenous but most frequent metabolic and endocrine disorder.


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