Insulin Homeostasis Protocol

Majid Ali, M.D.

A Free Access Distance-Learning Program for Integrative Medicine


insulin Homeostasis Protocol

A simple-to-understand and easy –to-implement protocol for restoring insulin homeostasis in chronic diseases designated “insulin homeostasis protocol” (the “Protocol”) is presented. This insulin-based protocol improves clinical results and is suitable for clinicians in solo practice, in small partnerships, large professional groups, or those in hospital-based practices with interest in healthful aging, disease prevention, and reversal of chronic disease.

Insulin:  the Primal Hormone

In the early 1990s,  the author developed an integrative diet and detox protocol to manage Type 2 diabetes (T2D) and prevent its complications. The study of insulin dynamics was not a part of this protocol. His interest in spontaneity of oxidation in nature as the primal driver of cellular injury and diseases processes1-4 led him to put forth oxygen models of aging,5 inflammation,6 pain,7  obesity,8 environmental illness,9  coronary artery disease,10chronic renal failure,11 ADHD,12 Alzheimer’s disease,13 environmental illness,14 cancer,15 and fibromyalgia.16 This work led to an interest in insulin dynamics in health and disease, and eventually to recognition of a clear need for a shift of focus from glycemic status to insulin homeostasis. Specifically, studies of insulin responses to glycemic loads in patients with diverse chronic immune-inflammatory, infectious, developmental, degenerative, metabolic, and neoplastic disorders established the following: (1) Rising blood concentrations develop in nearly all chronic diseases after varying durations of diseases activity; (2) The degrees of hyperinsulinism generally correlate with both the duration and intensity of the pathologic processes;  (3) Insulin spikes create insulin cascades – hyperinsulinism feeds upon itself; and (4) Therapeutically, clinical outcome in chronic diseases is compromised when coexisting hyperinsulinism is not effectively controlled. 
The author, a surgeon-turned-pathologist-turned integrative clinician and a long-term student of molecular biology of oxygen draws three primary inferences from his findings: (1) insulin is the primal energy hormone of the body; (2) hyperinsulinism is an energy response to meet increased repair-related energy demands of chronically injured cells and disrupted molecular pathways; and (3) Type 2 diabetes is rooted in insulin receptor dysfunction resulting from cell membrane injury and myriad adverse mitochondrial, cell membrane, and matrix effects of hyperinsulinism.17-22
Shifting the Focus From Glycemic Status to insulin Homeostasis
Recently, the author and his colleagues reported hyperinsulinism prevalence of 75.1% in a general population in New York metropolitan area.23 Their insulin database allowed them to explore the following aspects of hyperinsulinism-T2D continuum: (1) pathogenesis of insulin resistance; (2) hyperinsulinism-to-T2D progression; (3) stratification of hyperinsulinism for optimal clinical use; (4) pro-immune-inflammatory roles of insulin; (5) the central role of mitochondrial dysfunction in insulin dysregulation; (6) hyperinsulinism as an energetic response to chronic cellular injury; and (7) the profound therapeutic significance of insulin serving as the “minister of metabolism and energy” to “King Oxygen” of the human body.
3D Diabetes and Insulin Homeostasis  Protocol
The insulin homeostasis protocol (the Protocol) evolved as a three-prong approach comprising: (1) diet; (2) detox; and (3) dysoxic comorbidities (oxygen-related coexisting pathologic entities, including disrupted hypothalamic and related neural pathways which regulate the energy economy of the body. The three “diabetes 3D” subjects” are vast and clearly beyond the scope of this brief outline. Before I offer comments about for the three Ds, below is some information about the scientific underpinnings and rationale for the Protocol.
Insulin Protocol in Integrative Medicine
The author and his colleagues have employed  the Protocol in their integrative clinical work for over twenty years. Various aspects of the Protocol have been the subjects of several previous publication.24-26  All clinical and laboratory aspects of the diet, detox, and dysoxic comorbidities components of the Protocol are fully explained at This free-access website also includes a large library of published and unpublished articles and videos concerning the Protocol. This large effort was undertaken to promote ideas, not products.
Notable Strengths of the Protocol
The Protocol has some especial strength.   Notable among them are: (1) enhanced clinical results for individual patients (exta free access documented in the author’s Darwin and Dysox Trilogy12-14 and multiple case studies presented in this article); (2) free access internet-based distance learning for clinicians; (3) no clinical restrictions on the participants in the integrative model  of the dietary, detox, and dysoxic comorbidities  Protocol guidelines; (4) no restrictions on concurrent use of pharmacologic regimens; (5) simplicity and uniformity of record keeping format for the insulin database for patient education and publications (for examples of the tabular format for insulin and glucose profiles, go to the article entitled “Insulin Homeostasis Protocol”; and (6 initial insulin profiling and limited yearly follow-up testing done as parts of comprehensive assessment of the metabolic status of the patient.


1.             Ali M. Respiratory-to-Fermentative (RTF) Shift in ATP Production in Chronic Energy Deficit States. Townsend Letter for Doctors and Patients. 2004;253:64-65.
2.             Ali M. Succinate Retention. Comments Re: Chouchani ET, Victoria R. Pell VR, Edoardo Gaude E, et. al. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature. 2014;515:431–435.
3.             Ali Oxidative regression to primordial cellular ecology. J Integrative Medicine 1998; 2:4-55.
4.             Ali M. Oxygen and Aging. (Ist ed.) New York, Canary 21 Press. Aging Healthfully Book 2000.
5.             Ali M. The dysox model of aging.  Townsend Letter for Doctors and Patients.2005;269:130-134.
6.             Ali M. Oxygen governs the inflammatory response and adjudicates the man-microbe conflicts. Townsend Letter for Doctors and Patients. 2005;262:98-103.
7.             Ali M. Ali M. The Oxygen View of Pain: Every chronic pain represents cells’ cries for oxygen. Townsend Letter for Doctors and Patients. 2005;258:46-48-102.
8.             Ali M. Obesity is cellular oxygen deficiency state. Aging Healthfully.  2004;5:2-19.
9.             Ali M. Oxidative coagulopathy in environmental illness. Environmental Management and Health. 2000;11:175-191.
10.          Ali M. CAD Ali M, Ali O: AA oxidopathy: the core pathogenic mechanism of ischemic heart disease. J Integrative   Medicine 1997;1:6-112.
11.          Ali M. Renal Failure  Ali M. The dysox model of renal insufficieny and improved renal function with oxystatic therapies. Townsend Letter for Doctors and Patients.2005;267:101-108.
12.          Ali M. The ADHD-Autism-Oxygen Connection: The Larger-Head-Smaller-Brain Scenario. Townsend Letter-The examiner of Alternative Medicine. April, 2008.
13.          Ali M. Oxygen and Alzheimer’s Disease. The South African Journal of Natural Medicine. 2012;79:87-88.
14.          Ali M. Environmental illness
15.          Ali M. The Cancerization/De-cancerization Dynamics of the Dysox Oxygen Model  of Cancer. J Int Med. 2005;9:13-24.
16.          Ali M. Fibromyalgia: an oxidative-dysoxygenative disorder (ODD). J Integrative Medicine 1999; 3:17-  37.
17.          Ali M. Epidemic of Dysoxygenosis and the Metabolic Syndrome. In: The Principles and Practice of Integrative Medicine. Volume 5. Pp 246-256. Canary 21 Press. New York. 2005.
18.          Ali M. Dysox Model of Diabetes and De-Diabetization Potential. Townsend Letter-The examiner of Alternative Medicine. 2007; 286:137-145.
19.          Ali M. Oxygen, Insulin Toxicity, Inflammation, and  the Clinical Benefits of Chelation. Part I. Townsend Letter-The examiner of Alternative Medicine. 2009;315:105-109. October, 2009.
20.          Ali M. Oxygen, Insulin Toxicity, Inflammation, and  the Clinical Benefits of Chelation. Part II. Townsend Letter-The examiner of Alternative Medicine. 2009;315:105-109. October, 2009.
21.          Ali M. Importance of Subtyping Diabetes Type 2 Into Diabetes Type 2A and Diabetes Type 2B. Townsend Letter-The Examiner of Alternative Medicine. 2014; 369:56-58.
22.          Ali M. Dasoju S, Karim N, Amin J, Chaudary D. Study of Responses to Carbohydrates and Non-carbohydrate Challenges In Insulin-Based Care of Metabolic Disorders.  Townsend Letter-The Examiner of Alternative Medicine. 2016; 391:48-51.
23.          Ali M. Fayemi AO, Shifting Focus From Glycemic Statsus to Insulin Homeostasis. Ali M, Fayemi AO, Ali O, Dasoju S, Chaudhary D, Hameedi S, Amin J, Ali K, and Svoboda B. Shifting focus from glycemic status to insulin homeostasis for stemming global tides of hyperinsulinism and Type 2 diabetes. Townsend Letter – The examiner of Alternative Medicine. 2017;402:91-96.
24.          Ali M. Darwin, Oxygen Homeostasis, and  Oxystatic Therapies. Volume X, 3 rd. Edi The Principles and Practice of Integrative Medicine (2009) New York. Institute of Integrative Medicine Press.
25.          21. Ali M. The Principles and Practice of Integrative Medicine Volume  XI: 3rd. Edi. Darwin, Dysox, and Disease. 2000. 3rd. Edi. 2008. New York.  (2009) Institute of Integrative Medicine Press.
26.          22. Ali M. The Principles and Practice of Integrative Medicine Volume  XII: Darwin, Dysox, and Integrative Protocols. New York (2009). Institute of Integrative Medicine Press.

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