Majid Ali, M.D.

Alzheimer’s Disease Before the Supreme Court of Science – 2017



Alzheimer’s Before the Supreme Court of Science – 2017

I have subscribed and read the journal Nature over 25 for years. It is a journal of science, not of medicine. For some years, I have considered Nature as the supreme court of the world of science. When the U.S. supreme Court admits a case, it does so because it  beleives the question being presented to it rises to a level that concerns all of the country, not just one municipality or state. I regards materials published by Nature in the same way. In this light, let us  consider what nature says about the reality of the cause and treatment of Alzheimer’s disease.  

Below is text from an article entitled “Stop Alzheimer’s before it starts published by the Journal on July 13, 2017. The readers can see for themselves what is true and what is untrue in what they have bee  told by drug companies, doctors, and nurses. 

  1. In 2015, the global cost of Alzheimer’s disease was US$818 billion.
  2. By 2030, the number of people with the disease is expected to rise to more than 70 million worldwide.
  3. Unless there is a breakthrough in treatment, nearly one in every 2–3 people over 85 will have Alzheimer’s.
  4. Those who escape the disease will have at least one close friend or relative who can no longer converse with them, has no recollection of what happened minutes before and is reliant on round-the-clock care.
  5. Four drugs have been approved for treating Alzheimer’s Diases. None of them alters the course of the disease or treats the symptoms to a degree that’s detectable in individuals.
  6. Scores of other drug candidates have had no effect on amyloid-β plaques in humans. Some have even had serious adverse effects; an experimental amyloid-β vaccine caused inflammation in the brain of several patients.
  7. Clinical trials have predominantly focused on therapies aimed at treating people who have developed symptoms (memory loss, confusion and difficulties communicating) and begun to lose independence. In the past five years, investigators have started trials at an earlier stage — when memory loss is mild or absent but brain scans reveal the hallmark pathology of amyloid-β protein plaques. However, we think that the clock should be turned back even further — to when the signature brain pathology hasn’t yet appeared.
  8. Studies in mice genetically altered to develop amyloid-β plaques have shown that therapies that lower amyloid-β production are most effective when administered before the plaques have developed.
  9. Other studies indicate that Alzheimer’s progression may become a runaway process after a certain point.


Relevant Bibliography 

Links to articles and video follow the bibliography 

1. Canter RG, Penney J, Tsai L-H. The road to restoring neural circuits for the treatment of Alzheimer’s disease. Nature. 2016; 539, 187-196.
2. Ali M. Oxygen and Aging. (2nd ed.) New York, Canary 21 Press. 2000.
3. Ali M. Respiratory-to-Fermentative (RTF) Shift in ATP Production in Chronic Energy Deficit States. Townsend Letter for Doctors and Patients. 2004. 253: 64-65.
4. Ali M. Darwin, Oxygen Homeostasis, and Oxystatic Therapies. Volume X, 3 rd. Edi The Principles and Practice of Integrative Medicine (2009) New York. Institute of Integrative Medicine Press.
5. Ali M. The Principles and Practice of Integrative Medicine Volume XI: 3rd. Edi. Darwin, Dysox, and Disease. 2000. 3rd. Edi. 2008. New York. (2009) Institute of Integrative Medicine Press.
6. Ali M. The Principles and Practice of Integrative Medicine Volume XII: Darwin, Dysox, and Integrative Protocols. New York (2009). Institute of Integrative Medicine Press.
8. Ali M. Altered States of Bowel Ecology. (monograph). Teaneck, NJ, 1980.
9. Ali M. Oxygen, Inflammation, and Castor-Cise Liver Detox. Hormones. Townsend Letter-The examiner of Alternative Medicine. 2007.
10. Ali M. Lopez-Otin C, Blasco MA, Partridge L, et al. The hallmarks of aging. Cell. 2013;153:1194-1217.
11. Ali M. Insulin Homeostasis in a General Population ? Shifting the Focus. Townsend Letter for Doctors and Patients. (in press).
12. Ali M. Beyond insulin resistance and syndrome X: The oxidative-dysoxygenative insulin dysfunction (ODID) model. J Capital University of Integrative Medicine. 2001;1:101-141.


Articles and videos of interest


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