Mitochondrial Dysfunction in Type 2 Diabetes

Majid Ali, M.D.

—————————————————————————-In the oxygen model of diabetes (T2D), mitochondrial dysfunction plays a central role in the pathogenesis of Type 2 diabetes. I proposed this model about twenty years ago. Links to  pertinent citations are included below.

—————————————————————————-The scholarly article by Peti-Peterdi cited below would be of especial interest for readers who wish to study the oxygen model of diabetes.


Mitochondrial TCA cycle intermediates body fluid and acid-base balance

Journal of Clinical Investigation. 2013;123(7)2788-90
Intrarenal mechanisms play an important role in the maintenance of body fluid and electrolyte balance and pH homeostasis. Recent discoveries of new ion transport and regulatory pathways in the distal nephron and collecting duct system have helped to better our understanding of these critical kidney functions and identified new potential therapeutic targets and approaches. In this issue of the JCI, Tokonami et al. report on the function of an exciting new paracrine mediator, the mitochondrial the citric acid(TCA) cycle intermediate α-ketoglutarate (αKG), which via its OXGR1 receptor plays an unexpected, nontraditional role in the adaptive regulation of renal HCO(3⁻) secretion and salt reabsorption.

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