Category Archives: 3D Diabetes Reversal Plan

Is Diabetes A Sugar Problem? No.

Majid Ali, M.D.

Suite 3 C, 344 Prospect Avenue

Hackensack, New Jersey 07601

201-966-0027


 

Is diabetes mellitus (Type 2 Diabetes) a sugar problem? No. The abnormalities of blood sugar seen in diabetes are the consequences of the derangements of cellular energetics and toxicity that collectively create what is commonly called diabetes. Is diabetes an insulin problem? No. The abnormalities of insulin functions are the consequences of plasticized (chemicalized) and hardened cell membranes that immobilize the insulin receptors embedded in them. Is diabetes a problem of blood vessels that causes blindness, kidney failure, stroke, heart attacks, and neuropathy? No. The abnormalities of blood vessels are the consequences of oxidizing and deoxygenizing influences in diabetes.

In this column, I marshal evidence for my view that the state of insulin resistance should be regarded as a “hardened cell membrane state.” The so-called metabolic syndrome should be visualized as a “gummed-up matrix state.” Prediabetes should be seen as a “mitochondrial dysfunction state.” The strategies for the prevention and reversal of diabetes yield better long-term clinical results if diabetes is recognized as a “dysfunction oxygen signaling,” or dysox, state.

In type 1 diabetes, insulin itself becomes a potent autoantigen and initiates autoimmune injury to pancreatic islet cells.1-3 I will show how this recently documented role of insulin in the pathogenesis of diabetes fits in the dysox model of diabetes presented here. In type 2 diabetes, insulin cannot function – insulin resistance, in the common jargon – and hyperinsulinemia develops, which triggers and amplifies the inflammatory response.4-6 In all types of diabetes, the endothelial cells produce nitric oxide and other bioactive factors in abnormal quantities and proportions.7,8 Diabetes causes neuropathy, retinopathy, nephropathy, dementia, stroke, and heart attacks. I will describe how those complications of diabetes can be better understood when the problems are seen through the prism of oxygen signaling.


 

Clinical, Epidemiologic, and Experimental Evidence Links Obesity With Insulin Toxicity

The link is supported by known metabolic roles of nonesterified fatty acids (NEFAs) and altered paracrine and endocrine functions of fat cells (adipocytes) in the energy economy of the body. For example, in a healthy state, NEFAs serve as substrates for adenosine triphosphate (ATP) generation. In obesity, these fatty acids are retained in excess in biomembranes of all cell populations of the body and within adipocytes. NEFAs, along with trans fats and oxidized lipids, then “harden” the cell membranes to clamp down on insulin receptors – rusting and impacting the crank, so to speak – to cause insulin resistance.12 Those lipids also “gum up” the matrix, blocking molecular cross-talk there. Eventually, those elements, along with other toxins, uncouple respiration from oxidative phosphorylation and impede mitochondrial electron transfer events.


 

In obesity, output of fattening hormones in adipocytes (fat cells) is chaotic in the ways in which it further increases cellular fat build-up and sets the stage for the development of diabetes.13,14 However, the obesity/diabetes link does not prevail in all populations of the world. For instance, in India, there is also an epidemic of low body-weight (LBW) diabetes15 – a phenomenon that clearly points to the existence of environmental factors unrelated to obesity that are involved in the pathogenicity of diabetes, and supports the dysox model of diabetes.

A growing number of free radicals, transcription factors, enzymes, and proteins has been – and continues to be – implicated in the pathogenesis of diabetes, including:
· nitric oxide16,17
· inducible nitric oxide synthase (iNOS)18
· mitochondrial uncoupling proteins (UCPs)19-21
· proinflammatory cytokines22-24
· resistin25,26
· leptin27,28
· adipokines29
· adiponectin30
· tumor necrosis factor-alpha (TNF-a)31
· peroxisome proliferator-activated receptor gamma (PPARgamma)32-34
· nuclear respiratory factor-1 (NRF-1)35
· suppression of cytokine signaling (SOCS) proteins36
· retinol-binding protein-4 (RBP4)37
· antibodies against glutamic acid decarboxylase38
· prothrombotic species, including fibrinogen, von Willebrand factor, and plasminogen activator inhibitor (PAI-1), adipsin (complement D), and acylation-stimulating protein (ASP) 39-42
· heat shock protein 60, voltage-dependent anion channel 1 (VDAC-1), and Grp7543
· hypercoagulable platelets44


Oxygen, Diabetes, Insulin References 


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What Can Appna Contribute to Stemming Global Tides of Hyperinsulinism and Diabetes

 

What Might APPNA Contribute for Stemming Global Tides of Hyperinsulinism and Type 2 Diabetes?


Shifting Focus From Glycemic Status to Insulin Homeostasis
Majid Ali, M.D.  FRCS (Eng), FACP  5.14.2017. 11 AM

The author is available for personal communication concerning this paper with interested APPNA clinicians by phone at 212-873-2444 or by e-mail at askipm@aol.com.

Download a pdf version of this paper.

The author’s work in molecular biology of oxygen1-6and molecular biology of insulin7-12 led him to recognize a need for a shift of focus from glycemic status to insulin homeostasis (the “Shift”).13,14 Here he marshals strong basic science and epidemiological lines of evidence for the Shift (Tables 1-3), and  presents robust reasons for suggesting that  APPNA,  a dedicated physician community, consider a long-term organizational  initiative to contribute efforts to stem global tides of hyperinsulinism which predates Type 2 diabetes (T2D) by five,  ten, or more years.

During the years of hyperinsulinism-to-T2D progression, cellular populations in nearly all body organs suffer diffuse and incremental damage inflicted by undetected and unmanaged non-metabolic toxicity of insulin dysregulation. Notable among them are disorders of neurodevelopment (autism and dysautonomia15,16), blindness from insulin-induced optic neuritis,13 mitochondrial dysfunction,1,13 immune-inflammatory entities,13 endothelial dysfunction,17 vagus nerve dysfunction,18 persistent cellular repair response (after chemotherapy for cancer,19 for instance), and hepatic lesions (such as steatosis). In his broader oxygen-insulin perspective of hyperinsulinism8 the author recognizes hyperinsulinism as chronic energetic response to increased energy requirements of cellular repair processes.

It is noteworthy that all clinical and laboratory work done for the above-cited publications was completed without any private or government funding. The same held for author’s related works in molecular and cellular pathology, as well as in therapeutics in the fields of environmental medicine, clinical nutrition, and immune-inflammatory disorders in the holistic-integrative models presented in the 10th, 11th, and 12th volumes of The Principles and Practice of Integrative Medicine.20-22

Insulin Homeostasis Protocol

The central goal of the proposed “Insulin Homeostasis Protocol” (the “Protocol”) is for APPNA to develop and implement a long-term organizational plan for shifting focus from glycemic status to insulin homeostasis in order to: (1) improve clinical outcome of individual patients with integrative treatments: (2) simplify patient education for superior compliance; (3) build an organizational insulin database for ongoing studies of the non-metabolic and metabolic consequences of disrupted insulin homeostasis; (4) document the prevalence and patterns of progression of hyperinsulinism co-morbidities, including T2D; (5) gather clinical data for examining the efficacy of indigenous therapies; and (6) foster the science and philosophy of holism in healing.

The Protocol is designed to be an all-voluntary distance-learning (internet-based) program. No need for significant outside funding is anticipated for APPNA participating clinicians; the initial time commitment of the APPNA administrative staff is expected to be modest.

Notable Strengths of the Protocol

The Protocol has some especial strength.   Notable among them are: (1) enhanced clinical results for individual patients (extensively documented in the author’s Darwin and Dysox Trilogy20-22 and multiple case studies presented in this article); (2) no-cost internet-based distance learning for participating APPNA clinicians; (3) no clinical restrictions on the participants in the integrative model  of the dietary, detox, and lifestyle Protocol guidelines; (4) no restrictions on concurrent use of pharmacologic regimens; (5) simplicity and uniformity of record keeping format for the insulin database for publications (illustrated in Tables used for presenting ; (6) no need for contractual obligations for APPNA, nor for APPNA clinicians; and (7) no additional uncovered cost of initial post-glucose challenge insulin and glucose profiles, and limited follow-up yearly insulin tests  (as has been the case for the author and his colleagues).

Type 2 diabetes is a spreading pandemic. In 2013, China in a large national study reported a prevalence rate of prediabetes and Type 2 diabetes (T2D) (50.1% of adults).1 In 2017, the author and his colleagues reported a prevalence rate of hyperinsulinism of 75.1% in  a survey of post-glucose challenge insulin and glucose profiles in 684 subjects in New York metropolitan area.13 This, to the authors’ knowledge, was the first statistical documentation of hyperinsulinism-to-T2D progression with direct measurements of blood insulin and glucose concentrations with multiple timed blood samples following a 75-gram glucose challenge.  The much higher rate of hyperinsulinism (75.1%) in New York population than the prevalence of prediabetes and T2D among the Chinese (50.1%) is not surprising since tests for the glycemic status provide only indirect information concerning the underlying insulin dysregulation.

In the 201713 and earlier reports,7-12 the author and his colleagues explored the following questions: (1) How does insulin resistance begin; (2) What is optimal insulin homeostasis; (3)  What is the prevalence of hyperinsulinism in a general population of New York metropolitan area; (4) What are the patterns of progression and/or arrest of hyperinsulinism-to-T2D continuum; (5) What are the non-metabolic developmental, differentiative, immune-inflammatory, degenerative, and metabolic effects of undetected incremental degrees of insulin dysfunction; (6) How do the diagnostic efficiencies for T2D of post-glucose challenge and insulin responses compare with those of the standard glucose tolerance; (7) How does insulin-based hyperinsulinism modification and T2D reversal plan compare with those based on glycemic criteria, especially in the cases of gestational diabetes and large-sized babies; and (8) What might be the crucial clinical entities in which unmasked hyperinsulinism poses special hazards, i.e., autism, Asperger’s syndrome, pediatric dysautonomia, childhood weight gain and obesity, pediatric fatty liver, peripheral neuropathy,  drug-induced tissue repair responses (during chemotherapy for cancer, for instance), polycystic ovarian syndrome, pustular  acne, and diverse allergic and chronic immune-inflammatory disorders.

Insulin Dysregulation in Chronic Cellular Repair Responses

All repair mechanisms in the body have  expanded energy requirement demands. Insulin can be rightfully considered the master energy hormone of the body. From an evolutionary energetic perspective, the lowest blood insulin concentrations accompanied by unimpaired glucose tolerance have been designated optimal insulin homeostasis  (Table 1).  Table 2 showing the correlation of incremental glycemic changes sheds light on the hyperinsulinism-T2D continuum. Our article entitled “Shifting Focus From Glycemic Status to Insulin Homeostasis is posted in full at www.alidiabetes.org, and furnishes a large body of original observations, including many of the above-cited forms of toxicity of hyperinsulinism fully referenced.

Table 1. Insulin Homeostasis Categories in 506 Study Subjects Without Type 2 Diabetes
Insulin Category* Percentage of Subgroup Mean Peak Glucose  mg/dL(mmol/mL) Mean Peak Insulin (uIU/mL)
Exceptional Insulin Homeostasis    N =  12** 1.7% 110.2     (6.12) 14.3
Optimal Insulin Homeostasis            N =  126 24.9 % 121.2     (6.73) 26.7
Hyperinsulinism, Mild                         N =  197 38.9 % 136.5   (7.58) 58.5
Hyperinsulinism,  Moderate              N =  134 26.5 % 147.0    (8.16) 109.1
Hyperinsulinism,  Severe                   N =  49 9.7 % 150.0    (8.33) 231.0
#   Correlation coefficient, r value, for means of peak glucose and insulin levels in the five insulin categories is 0.84.

*Criteria for classification: (1) Exceptional insulin homeostasis, a subgroup of optimal insulin homeostasis with fasting insulin concentration of <2 uIU/mL and mean peak insulin concentration of <20; (2) optimal insulin homeostasis, peak insulin <40 accompanied by unimpaired glucose tolerance; (3) mild

Table 2. Insulin Homeostasis Categories in 178 Study Subjects With Type 2 Diabetes
Insulin Category Percentage of Subgroup Mean Peak Glucose mg/dL(mmol/mL) Mean Peak Insulin (uIU/mL)
T2D With Hyperinsulinism, Mild          N =  53 29.0% 252.0   (14.00) 55.4
T2D With Hyperinsulinism, Moderate N =  42   24.0% 242.1   (13.45) 112.4
T2D With Hyperinsulinism, Severe       N =  24 13.9% 224.6   (12.47) 298.0
T2DF With Low Insulin Levels               N =  59 33.1% 294.0    (16.33) 22.9

Reading Insulin/Glucose Profiles As Examining Surgical Pathology Slides

Within some months of beginning my study of insulin homeostasis with 3-hour post-glucose-challenge insulin and glucose profiles, I found myself reading the profiles as I read microscopic slides as a hospital surgical pathologist. One might expect that individual subjects will display wide variations in their insulin and glucose profiles in most instances. This, indeed, is the case . This point is amply demonstrated in case studies shown in Tables 3-7. Table 3 shows what is usually dismissed as an error of omitting the glucose challenge by the patient or the  lab staff since the “flat” post-glucose-challenge tolerance pattern is not a generally recognized entity. It is caused by a brisk initial insulin spike which masks the expected initial glucose spike. This can be readily proved by taking measurements at 1/2-hour post-challenge blood sample. Tables 7 documents insulin dysregulation in autism and pediatric dysautonomia.

Table 3. Optimal Insulin Homeostasis With Very Low Blood Insulin Concentrations and Unimpaired “Flat” Glucose Tolerance Curve* of A 52-Yr-Old 5’1” Woman With Constipation and Osteoarthritis.
Fasting 1-Hr 2-Hr 3-Hr
Insulin uIUi/mL <2 17 15 6
Glucose mg/mL 75 61 72 71

 

Table 4. Insulin and Glucose Profiles of 75-Yr-Old 5’7” Woman Weighing 192 lbs. Who Presented Following A Coronary Bypass Procedure With Fatigue, Sinusitis, and Without Known Type 2 Diabetes (Not An Uncommon Case In the Author’s Integrative Clinical Practice). A1c 5.6%.
6.3.2010 Fasting 1-Hr 2-Hr 3-Hr
Insulin uIUi/mL 9.8 25 92.4 2.2
 Glucose mg/mL 112 170 241 273
7.23.2013. Insulin Tests Not Ordered By Her Primary Physician. A1c 5.8%
Insulin uIUi/mL
Glucose mg/mL 97 159 219 247
5.11.2014. ”Mostly Good Compliance” By  Patient’s Account.  A1c  5.7
Insulin uIUi/mL 6.43 58.2 33.87 6.4
Glucose mg/mL 99 182 139 81
2016 Hospitalized for Angina. A1c 5.7. No Diabetic Drugs Prescribed By the Attendning Cardiologist.

 

Table 5. Reversal of Type 2 Diabetes in a 78-Yr-Old 5’2” Woman Weighing 162 Lbs. Achieved By Dramatic Hyperinsulinism Modification (Reduction of 3-Hr Insulin from 152 uIU/mL in 2013 to 75.2 in 2014 to 39.7 in 2015, indicating  restoration of Insulin Homeostasis.
4.30.2013 Fasting 1-Hr 2-Hr 3-Hr
Insulin uIUi/mL 16 59 113 152
 Glucose mg/mL 112 214 241 155
10.17.2014,   A1c  6.3%
Insulin uIUi/mL 23.8 36.9 114.7 75.2
 Glucose mg/mL 116 253 297 172
4.14.2015,  A1c 5.9%
Insulin uIUi/mL 6.2 42.9 51.2 39.7
 Glucose mg/mL 96 193 112 105

 

Table 6. Severe Hyperinsulinism In A Previously Health 13-Yr-Old Girl With Multiple Hospitalizations for Recurrent Pneumonia, Thrombocytopenia, Polyarthralgia, Polymyalgia , and Severe Optic Neuritis With Complete Loss of Vision in Right Eye. Her Final Diagnosis in the Hospital was Systemic Lupus Erythematosus*
Fasting 1Hr 2Hr 3Hr
Insulin uIU/mL 27.9 424.0 718.2 571.7
Glucose mg/mL 70 157 150 111
Insulin and Glucose Profiles Obtained After Four Months of Robust Integrative Parenteral Nutritional and Detox Therapies With Focus on Restoration of Gut Flora.
Insulin uIU/mL 7.2 238.5 208.0 132.0
Glucose mg/mL 81 181 130 97
*The patient showed dramatic improvement  in all areas except in right eye blindness. Follow-up questioning revealed a history of massive exposure to mold overgrowth while playing in an abandoned building.

Information Sources

I consider the journal Nature to be the supreme source of information in the world of science. Since 2015, Nature frequently e-published my comments expressing holistic-integrative perspective on health and healing concerning major articles published by the journal. Below are excerpts from five of those pieces on the subject of this proposal for APPNA (citations within the text are originals from e-publications):

  1. Shifting Focus From Glycemic Status to Insulin Homeostasis14

 Type 2 Diabetes (T2D) is rapidly eclipsing other chronic diseases in becoming the preeminent threat to human health worldwide…. The work of Yamaguchi and colleagues must be celebrated in this larger context. Their previous work involved generation of whole organs from donor pluripotent stem cells using their chimaera-forming ability to complement organogenesis-disabled host animals in vivo. They now report generation of autologous functional islets with interspecies organogenesis through interspecies blastocyst complementation. This stellar work advances the goal of treating diabetes with islet transplantation. Here, Yamaguchi  et al. also put forth a serious challenge to physician community: How to protect transplanted islet cells from the host elements that caused hyperinsulinism leading to Type 2 diabetes in the first place?

  1. Obesity, Energetics, Environment, and Hyperinsulinism23

Just how error-prone and self-correcting is science? Allison and colleagues raise a question that physicians often raise – in hospitals, clinics, and laboratories. A more compelling question for those interested in obesity, energetics, and inflammation, and insulin homeostasis is: How can the subjects of obesity and energetics be investigated and/or discussed without considering the tedious and disconcerting matter of environmental and inflammatory toxins that impair mitochondrial function and oxygen signaling? Automobile mechanics know well how their engines get clogged and lose efficiency and mileage. In 2004, the author published data concerning impaired mitochondrial function in chronic immune-inflammatory and metabolic disorders.1  His observations were validated by the work of others as well as his follow-up studies.23

  1. Osteocrin, Making Connections, and Autism16

Ataman et al. linked osteocrin, a gene expressed in muscles and bones, to a new primate-specific enhancer sequence that binds to a myocyte enhancer factor 2 (MEF2.) (ref. 1). MEF2C mutations resulting in haploinsufficiency represent a form of intellectual disability in humans. (ref.2,3). MEF2A- and MEF2C-binding sites are enriched in genes associated with idiopathic autism spectrum disorder (ref. 4).

This new osteocrin work is especially important for integrative clinicians who care for autism and other disorders of developmental neurobiology. No pharmacologic agents to treat autism spectrum are available at this time. However, it is well established that neuronal activity triggers distinct transcriptional responses in different neuronal subtypes (ref. 5) This offers an opening for integrative clinicians to investigate the potential benefits of non-pharmacologic approaches to enhance neuronal activity to evoke desirable neurological responses for improved clinical outcomes. Notable among these are dietary, nutritional, metabolic, and gut mircobiota-directed therapies, as well as educational and behavioral programs. Specifically, the use of injectable and oral glutathione, methylcobalamine, taurine, calcium, magnesium, vitamin B complex usually yield gratifying results in treating atism (ref. 6,7).

The work of Ataman et al inspires this writer to pursue his impeded progenitor cell progression model of autism (ref. 6). He put forth this unifying model as a frame of reference for establishing clinical priorities to improve clinical results by identifying and addressing all prenatal and postnatal challenges to developmental neurobiology which seem relevant to the pathogenesis of ASD. The core tenet of this model is impeded neuronal progenitor cell progression to mature neurons during antenatal and postnatal lives caused in autism is disrupted oxygen signaling (ref. 6,8,9) resulting from: (1) Krebs cycle dysfunction (ref. 10); (2) overdriven immune-inflammatory dynamics (ref. 11); and (3) disruptions of insulin homeostasis and IGF1-dynamics (ref. 12,13). The members of this trio amplify challenges to progenitor cell progression posed by one another, and impede progenitor cell progression during antenatal and postnatal lives.

  1. Insulin.Autism.Hypothalamus24

The work of Stanley et al. points out how their constructs targeting glucose-sensing neurons will also be applicable to other areas, including insulin signaling. I have two specific reasons for celebrating this work. First, my work with hyperinsulnism and diabetes led me to recognize a clear need for a shift of focus from glycemic status to insulin homeostasis for stemming the tide of Type 2 diabetes in children (ref. 2-4). Second, I have special interest in the subject of hyperinsulinism in children with neurological challenges, such as autism and dysautonomia. (ref.5) Readers might find the following data concerning four children with hyperinsulinism, two with autism and two with dysautonomina, interesting. The insulin and glucose profiles were obtained with blood samples drawn at fasting and 1-hour, 2-hour, and 3-hour after a 75-gram challenge. I also include an insulin profile of a healthy subject with unimpaired glucose tolerance as a control. Insulin and glucose concentrations in 3-hour insulin and glucose profiles of  four children given below are expressed in uIU/ml and mg/mL respectively.

Table 7. Insulin and Glucose Profiles of Two Children each With Autism, and Dysautonomia, and One Control Child .
Fasting 1-Hr 2-Hr 3-Hr
Autism Case 1
 Insulin uIU/mL 24.4 73.8 71.6 28
Glucose mg/mL 95 79 79 69
Autism Case  2
Insulin uIU/mL 6.2 40.3 41.5 24.8
Glucose mg/mL 96 131 109 57
Pediatric Dysautonomia Case 1
Insulin uIU/mL 9.3 90.7 119.9 53.8
Glucose mg/mL 78 165 141 99
Pediatric Dysautonomia Case 1
 Insulin uIUi/mL 3.9 49.59 13.1 7.8
Glucose mg/mL 84 96 71 77
Control Subject Without Any Neurologic Disorder
Insulin uIU/mL <2 18 4 <2
Glucose mg/mL 77 109 74 52

 

  1. Darwin Moms, Nursing Milk, and Antibiotic Resistance25

Darwin moms have much to teach clinicians like me. To cite one example, women in Punjab diligently follow the family tradition of mustard oil rubs over their bellies daily for forty days after delivering a baby. I recommend this simple remedy to my American patients who nearly always find it beneficial in improving bowel health and reducing abdominal fat. They also report good results with castor oil rubs for their colicky babies.

Darwin moms have taught me much about many other remedies for controlling pregnancy-related digestive-absorptive disruptions and for improving their nutritional,  metabolic, and immune status, as well as of their children. Such measures profoundly affect the nourishing quality and safety of nursing milk, a crucially important immune booster. This approach can be expected not only to reduce the need for antibiotics but also diminish the frequency and intensity of their adverse effects when antibiotics cannot be avoided.

APPNA and Global Challenges of Disrupted Oxygen and Insulin Signaling

In closingAPPNA has an impressive world-class “clinician capital.” What might it contribute to the daunting challenge of stemming global tides of diabetes? Hyperinsulinism is recognized not only as the primary pathogenetic  mechanism for Typ2 diabetes but also as playing central roles in  diverse developmental, diffferentiative,  immune-inflammatory,  cardiovascular, neurologic, hepatic, endocrine, and cellular repair-related pathologies. Within the broader evolutionary context, the incremental “non-metabolic effects” of disrupted insulin homeostasis inflict diffuse cellular injury in nearly all organ systems of the body. The case of a 13-yr-old with total loss of vision in one eye presented in Table 6 and those of children with autism and dysautonomia in Table 7 offer intellectual and clinical challenges worthy of APPNA physicians. The integrative clinical Protocol guidelines proposed here also harness myriad low-cost indigenous therapies. The oxygen-insulin dimensions of the Protocol provide the scientific underpinning and rationale for gauging and engaging therapeutic aspects of molecular biology of oxygen and insulin.

In this light, APPNA clinicians considering the Protocol may look forward to exploring rewarding new dimensions of the new global realities of health and healing. Excerpts from the writer’s comments published online by the journal Nature provide windows to some of these dimensions. I add here that I consider publications in Nature analogous to the U.S Supreme Court admitting cases – to be presented, argued for and against, and then to be ruled on.

References

  1. M. Respiratory-to-Fermentative (RTF) Shift in ATP Production in Chronic Energy Deficit States. Townsend Letter for Doctors and Patients. 2004;253:64-65.
  2. Chouchani ET, Victoria R. Pell VR, Edoardo Gaude E, et. al. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature. 2014; 515:431–435.
  3. Ali M. Succinate Retention. In: Chouchani ET, Victoria R. Pell VR, Edoardo Gaude E, et. al. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature. 2014;515:431–435. Data after references).
  4. Ali M. Oxygen and Aging. (Ist ed.) New York, Canary 21 Press. Aging Healthfully Book 2000.
  5. Ali M. Dysox Model of Diabetes and De-Diabetization Potential. Townsend Letter-The examiner of Alternative Medicine. 2007; 286:137-145.
  6. Ali M. Oxygen, Insulin Toxicity, Inflammation, And  the Clinical Benefits of Chelation. Part I. Townsend Letter-The examiner of Alternative Medicine. 2009;315:105-109. October, 2009.
  7. Ai M. Ali’s Plan for Reversing Diabetes. New York, Canary 21 Press. Aging Healthfully Book 2011.
  8. Ali M. Oxidative regression to primordial cellular ecology. J Integrative Medicine 1998; 2:4-55.
  9. Oxygen, Insulin Toxicity, Inflammation, and  the Clinical Benefits of Chelation. Part I. Townsend Letter-The examiner of Alternative Medicine. 2009;315:105-109. October, 2009.
  10. Ali M. Importance of Subtyping Diabetes Type 2 Into Diabetes Type 2A and Diabetes Type 2B. Townsend Letter-The Examiner of Alternative Medicine. 2014; 369:56-58.
  11. Ali M. Dasoju S, Karim N, Amin J, Chaudary D. Study of Responses to Carbohydrates and Non-carbohydrate Challenges In Insulin-Based Care of Metabolic Disorders. Townsend Letter-The Examiner of Alternative Medicine. 2016; 391:48-51.
  12. Ali M. Epidemic of Dysoxygenosis and the Metabolic Syndrome. In: The Principles and Practice of Integrative Medicine. Volume 5. Pp 246-256. Canary 21 Press. New York. 2005.
  13. Ali M. Ali Fayemi AO, Shifting Focus From Glycemic Statsu to Insulin Homeostasis. Ali M, Fayemi AO, Ali O, Dasoju S, Chaudhary D, Hameedi S, Amin J, Ali K, and Svoboda B. Shifting focus from glycemic status to insulin homeostasis for stemming global tides of hyperinsulinism and Type 2 diabetes. Townsend Letter – The examiner of Alternative Medicine. 2017;402:91-96.
  14. Ali M. Shifting Focus From Glycemic Status to Insulin Homeostasis. E-comments In Nature. 2017;542:191.Re: Kobayashi T, Yamaguchi T, Hamanaka S, et al. Generation of rat pancreas in mouse by interspecies blastocyt injection of pluripotent stem cells. Cell. 2010;142:787-799.
  15. Ali M. Ali M. Molecular basis of Autism and Dysautonomia. Townsend Letter – The examiner of Alternative Medicine . In Press.
  16. Ali M. Osteocrin, Making Connections, and Autism. 2016;539:242.
  17. Arcaro G, Cretti A, Balzano S, et al. Insulin Causes Endothelial Dysfunction in Humans: Sites and Mechanisms. Circulation. 2002;105:576-582.
  18. Lustig RH, Rose SR, Burghen GA, et al. Hypothalamic obesity caused by cranial insult in children: Altered glucose and insulin dynamics and reversal by a somatostatin agonist. The Journal of Pediatrics. 1999;135:162-168.
  19. Ali M. Cancer,-Endothelium Dynamics, and DR6-Based Anti-Metaststic Therapies. Comments e-published in: 2016;536:215-218.
  20. Ali M. Darwin, Oxygen Homeostasis, and  Oxystatic Therapies. Volume X, 3 rd. Edi The Principles and Practice of Integrative Medicine (2009) New York. Institute of Integrative Medicine Press.
  21. Ali M. The Principles and Practice of Integrative Medicine Volume  XI: 3rd. Edi. Darwin, Dysox, and Disease. 2000. 3rd. Edi. 2008. New York.  (2009) Institute of Integrative Medicine Press.
  22. Ali M. The Principles and Practice of Integrative Medicine Volume  XII: Darwin, Dysox, and Integrative Protocols. New York (2009). Institute of Integrative Medicine Press.
  23. Ali M. Obesity, Energetics, Environment, and Hyperinsulinism. e-comments. In: Nature. 2016;530:27.
  24. Ali M. Autism.Hypothalamus. e-published at www.Nature.com. In: Nature. 2016;531:647-650.
  25. Ali M. Darwin Moms , Nursing Milk, and Antibiotic Resistance. E-published at Nature.com. 533:212.

 

d.
Table 1. Insulin Homeostasis Categories in 506 Study Subjects Without Type 2 Diabetes
Insulin Category* Percentage
of Subgroup
Mean Peak
Glucose mg/dL
(mmol/mL)
Mean Peak
Insulin
(uIU/mL)
Exceptional Insulin Homeostasis N = 12** 1.7% 110.2 (6.12) 14.3
Optimal Insulin Homeostasis N = 126 24.9 % 121.2 (6.73) 26.7
Hyperinsulinism, Mild N = 197 38.9 % 136.5 (7.58) 58.5
Hyperinsulinism, Moderate N = 134 26.5 % 147.0 (8.16) 109.1
Hyperinsulinism, Severe N = 49 9.7 % 150.0 (8.33) 231.0
# Correlation coefficient, r value, for means of peak glucose and insulin levels in the five
insulin categories is 0.84.
*Criteria for classification: (1) Exceptional insulin homeostasis, a subgroup of optimal
insulin homeostasis with fasting insulin concentration of <2 uIU/mL and mean peak insulin
concentration of <20; (2) optimal insulin homeostasis, peak insulin <40 accompanied by
unimpaired glucose tolerance; (3) mild

Dr. Ali’s Nutrient and Herbal Protocols for Preventing and Reversing Diabetes

Majid Ali, M.D.

201-996-0027

Suite 1 C, 344 Prospect Ave, Hackensack, NJ 07601


Below are the nutrient, herbal, and spice protocols  formulated by Dr. Ali and prescribed for his patients  for over 30 years. Dr. Ali for the prevention, reversal, or control of diabetes. He highly recommends that they be used under a clinician’s supervision. A special precaution suggested for the clinicians is to consider blood creatinine level of the patient as an indicator of kidney function when prescribing protocols containing potassium, although the potassium doses included are modest.

Two Most Important Questions

Is Diabetes a Sugar Problem?

The Answer: NO.

Is Diabetes An Insulin Problem?

The Answer: Yes. Yes.


Unless specified otherwise, the word at this web site is used for Type 2 diabetes.


BEWARE!

1.   If you think, diabetes is a sugar problem, tests done for blood sugar levels for screening for diabetes will be misleading most of the time.
2.   The diagnosis of diabetes will be delayed for five, ten, or more years.
3.   If you are overweight, it will be much more difficult to lose weight. 
4.   Unless you are at your optimal weight, undetected insulin toxicity will injure all your body organs to varying degrees until diabetes is diagnosed and treated for years, usually five to ten or more years.
 

Important Links
to
Dr. Ali’s Free Diabetes Course
Diet for Preventing, reversing, and controlling diabetes
Special Recipes for Preventing, reversing, and controlling diabetes

Diabet Protocol

 for Prevention, Reversal, and Control of Diabetes
Two Capsules on Alternate Days
Component /Ingredient
Daily Dose
How It Works
Chromium
100 mcg
For regulating carbohydrate metabolism, and  controlling blood glucose, and blood pressure, One of diabetes mineral trio (with Selenium, and Molybdenum),  for carbohydrate metabolism, mineral trio, along with Selenium, and Molybdenum, 
Gymnema sylvestre
750 mg
Curbs appetite, Reduces craving for sweets, Increases Energy, Quick recovery after physical activity
Neem extract
50 mg
All-purpose diabetes prevention and reversal
Huckleberry leaf
100 mg
Preserves kidney health and for all-purpose diabetes prevention and reversal
Vanadyl sulfate
20 mg
Complements Gymnema sylvestre

Vascular Protocol

 for Prevention, Reversal, and Control of Vascular Complications of Diabetes. One capsule Twice Daily
Component /Ingredient
Dose
How It Works
Arginine
100 mg
Cardioprotective, enhances heart strenth
Carnitine
100 mg
Cardioprotective, enhances heart strenth
Selenium
50 mcg
Vascular health
Hawthorne Pyridoxine HCL
200 mg
4:1 Extract
For normalizing blood pressure, anxiety control
Allium
300 mg
For blood health and circulation
Pyridoxine HCL
 
For protein and amino acid metabolism
Vit B6 (as pyridoxine HCL)
100mg
Protein metabolism,
Folic acid
800 mcg
 
Vitamin B 12
1000 mcg
 
Bromlain
200 mg
Antinflammatory, precents microclot formation in circulating blood
 
For anxiety associated with prediabetes or diabetes, Howthorne can used as tincture and combined with tincture of assionflowert, seven drops each added to once of cold water and sipped dlowly. This combination can be repeated three times inn24 hours, if needed.
 

K-Mag-Tau Diabetes Protocol

 for Bowel Detox In Prevention, Reversal, and Control of Diabetes

One Tablet Twice daily

Component /Ingredient
Amount
In Mgs
How It Works
Potassium
50
Highly recommended for their complementary benefits of bowel-blood detox for diabetes, circulation, and heart health
Magnesium
150
Taurine
250
Oral Chelation Protocol for Diabetes and Heart
 for Prevention, Reversal, and Control of Diabetes, Stroke, and Diabetic Heart and Vascular Complications
One Tablet Twice daily
Component /Ingredient
Amount
In Mgs
How It Works
EDTA
1000 mg
All ingredient produce their benefits by their integrated roles in cleansing blood, preventing stickiness of blood cells, preserving endo cells (endothelial lining the inside of blood vessels. ner (endo cells)
Magnesium
250 mg
Potassium
25 mg
Taurine
250 mg
MSM
100
Glutathione
25
Vitamin C
500

Turmeric-Vitamin C Protocol

 for Prevention, Reversal, and Control of Diabetes
Twice Daily, Take three Times A Day If Any infection coexist
Component /Ingrediant
Amount
In Mgs
How It Works
Turmeric
1.3 teaspoon
Cleanses blood, improves circulation, reduces stickiness of blood cells
Vitamin C
1000 mg
Antioxidant, Improves Blood Circulation Blood cleanser
 

Blood Cells Tell The Insulin Toxicity Story

Healthy Blood Cells for Comparative Study. Figure 1
Early Stress on Red Blood Cells (lower picture) . Figure 2
Description: https://i0.wp.com/web.archive.org/web/20071019123118im_/http://www.jintmed.com/pg31.jpg
.

Microplaques in Circulating Blood

When Blood Glucose Level Rises Above 200 mg/dL

Description: https://i2.wp.com/www.drali1.org/13-14.jpg
Figure 13 (top) and figure 14 (bottom) show two microplaques in a patient who had received three unsuccessful angioplasties for advanced IHD. Photomicrographs were taken the day after a major nosebleed. Note the compaction of necrotic debris and blood elements in microplaques as contrasted with loose structure of microclots in figure 11.


Red Blood Cells in a Micro-clot In Uncontrolled Diabetes (upper Picture) Figure 3
Red Blood Cell Clot Breaking Up (lower Picture) Figure 4
Description: https://i1.wp.com/www.drali1.org/11-12.jpg

Micro-plaque Formation In Uncontrolled Diabetes (both pictures) Figures 5-6
Description: https://i2.wp.com/www.drali1.org/13-14.jpg

Description: https://i2.wp.com/www.drali1.org/7-8.jpg
Figure 7 (top) illustrates severely damaged erythrocytes in a 52-year-old man with persistent atrial fibrillation. Close examination shows some zones of congealing surrounding many damaged red blood cells.
Dr. Ali’s Video Library

How Do You Reverse Diabetes Majid Ali MD on Vimeo

https://vimeo.com/96366665

 
https://vimeo.com › Majid Ali › Videos
May 24, 2014 – Uploaded by Majid Ali
Professor Majid Ali shares information about “How Do You Reverse Diabetes
 

How Do You Reverse Diabetes Majid Ali MD on Vimeo

 
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May 24, 2014 – Uploaded by Majid Ali
Professor Majid Ali shares information about “How Do You Reverse Diabetes
You’ve visited this page 2 times. Last visit: 6/11/18

What Is Your Diabetes Subtype? Majid Ali MD on Vimeo

 
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May 19, 2014 – Uploaded by Majid Ali
I recognize two subtypes of diabetes Type 2: diabetes Type 2A (high insulin) anddiabetes Type2 B (insulin …

Vegetarian Diet for Type 2 Diabetes Majid Ali MD on Vimeo

 
https://vimeo.com › Majid Ali › Videos
Apr 23, 2014 – Uploaded by Majid Ali
Professor Majid Ali shares information about “Vegetarian Diet for … Vegetarian Diet for Type 2 Diabetes Majid …
Can I Have Diabetes With Normal A1c Test Majid Ali MD

My Top Three Weight Loss and Anti-diabetes Omelettes Majid Ali MD

Two Most Important Questions After Diabetes Diagnosis Majid Ali MD

Diabetes and insulin Majid Ali MD

How Do I Reverse Diabetes Majid Ali MD

Top Seven for Diabetes Foot

Majid Ali, M.D.


What Is Diabetic Foot?

What Is Insulin Foot?

A diabetic foot is a generic term used for any chronic pathologic lesions (conditions) that results directly from diabetes (Type I, Type II, or other types or diabetes, or from chronic complications of diabetes of any type.
Since hyperinsulinism (insulin toxicity) predates Type 2 diabetes (T2D, the common form of diabetes mellitus)) by five, ten, or more years, and since diabetes foot often develops during these years, the term “insulin foot” is more appropriate than diabetes foot. The use of insulin foot draws sharp focus on insulin, both for the patient and the physician.

Signs and Symptoms of Insulin Foot

1. Pain
2. Low skin temperature with or without cold sensitivity
3. Numbness, tingling, pins and needles
4. Skin color change (redness, pigmentation change)
5. Loss of sensation (leading to cigarette burn for instance)
6. Slow healing wounds
7. Slow healing infections

Common terms used  for diabetic foot include:
 
1.   Diabetic nerve pain
2.   Diabetic neuropathy
3.   Diabetic foot pain
4.   Diabetic peripheral nerve dysfunction
5.   Diabetic peripheral vascular dysfunction

Top Seven for Diabetic Foot 

1.     Optimal Diabetes Control With Insulin Detox
2.     Attention to Early Negative Changes
            2. a  Poor circulation
            2.b  Pigmentation changes
            2.c   Nail fungus
            2.d  Poorly healing small wounds
            2.e  Poorly healing minor infections
            2.f  Foot and ankle puffiness
            2.g  Local pressure changes
3.        Vigorous treatment of early infections         
4.       Castor oil topical for early inflammatory lesions
5.       Hydrogen Peroxide foot soaks
6.       Nutrient Supplementation for Improved Circulation


 


Dr. Ali’s VideoLibrary

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This is a pragmatic view of an integrative physician, not a delusional plausibility of an ideologue. I hope you will consider the Program. It should serve you well for life. Kindest regards, Majid Ali, M.D.. Majid Ali, M.D. Updated June 20, 2010. COURSE 1: PHILOSOPHY OF BEING ONE’S OWN PRIMARY PHYSICIAN.
Jun 11, 2014 – The matters of doubt and uncertainty are of central importance to Being One’s Own Primary Physician. The uncertainty principle offers us an antidote to the risk of habitual thinking, blind trust, and static belief that impedes learning and threatens success. The subject of uncertainty brings to mind some of the …
May 11, 2014 – If your symptoms recurred after sinus surgery, please think of mold allergy, mold infections, and mold toxins. For the … Being One’s Own Personal Physician. I define … For example, a forty-year-old man who develops acute sinusitis and fever cannot be his primary physician for that acute illness. However …
Aug 20, 2014 – Majid Ali, M.D.. My patients with coronary heart disease have taught me this: Heart disease is a state of separation from one’s nature. This separation is caused by: 1. Deep disappointments of ….. For reversing coronary artery disease one must become one’s own primary physician. This, however, takes time.
Dec 25, 2014 – In the United States today, blocker drugs, stents, and bypass procedures are promoted as the primarytherapies for coronary artery disease. … This is what I call being one’s own doctor—cardiologist in the current context. … A Chick Comes Out of an Egg and Drops Dead of a Heart AttackMajid Ali MD …
Jul 8, 2014 – What Is Allergy? A Great Masquerader That Must Be Banished to Enjoy Health Majid Ali, M.D. Allergy is a great masquerader of the immune system. Sneezing, stuffy nose, itchy eyes, skin rashes, and sinusitis are only the surface problems in allergy. There are many deeper and more serious problems …
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Being One’s Own Primary PhysicianMajid Ali, M.D.. I define disease in two ways: * First, disease is a state of separation from one’s nature. * Second, disease is a state of evolution in reverse. Since no one else can know one’s nature —nor the degrees of separation from it—one can have only one authenticphysician: …
Sep 3, 2014 – Posts about Majid Ali MD written by Majid Ali MD. … far beyond the classical and wholly inadequate notion of it being a process characterized by edema, erythema, tenderness, pain, and infiltrate of inflammatory cells. ….. For reversing coronary artery disease one must become one’s own primary physician.

store.payloadz.com › Movies and Videos › Educational
Buy and Download > Description. In this 35-minute video seminar, Professor Majid AliM.D. explains why he rejects the diagnostic criteria for prediabetes established by the American Diabetes Association (ADA) and the World Health Organization (WHO). He asserts diabetes can neither be prevented nor reversed as long …

Jun 11, 2014 – The matters of doubt and uncertainty are of central importance to Being One’s Own Primary Physician. The uncertainty principle offers us an antidote to the risk of habitual thinking, blind trust, and static belief that impedes learning and threatens success. The subject of uncertainty brings to mind some of the …
May 11, 2014 – If your symptoms recurred after sinus surgery, please think of mold allergy, mold infections, and mold toxins. For the … Being One’s Own Personal Physician. I define … For example, a forty-year-old man who develops acute sinusitis and fever cannot be his primary physician for that acute illness. However …
Aug 20, 2014 – Majid Ali, M.D.. My patients with coronary heart disease have taught me this: Heart disease is a state of separation from one’s nature. This separation is caused by: 1. Deep disappointments of ….. For reversing coronary artery disease one must become one’s own primary physician. This, however, takes time.
Dec 25, 2014 – In the United States today, blocker drugs, stents, and bypass procedures are promoted as the primarytherapies for coronary artery disease. … This is what I call being one’s own doctor—cardiologist in the current context. … A Chick Comes Out of an Egg and Drops Dead of a Heart AttackMajid Ali MD …
Jul 8, 2014 – What Is Allergy? A Great Masquerader That Must Be Banished to Enjoy Health Majid Ali, M.D. Allergy is a great masquerader of the immune system. Sneezing, stuffy nose, itchy eyes, skin rashes, and sinusitis are only the surface problems in allergy. There are many deeper and more serious problems …
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Get appointment information and hours of operation for Majid Ali, practicing Public Health & General Preventive Medicine doctor in New York, NY.
Missing: being ‎own
Being One’s Own Primary PhysicianMajid Ali, M.D.. I define disease in two ways: * First, disease is a state of separation from one’s nature. * Second, disease is a state of evolution in reverse. Since no one else can know one’s nature —nor the degrees of separation from it—one can have only one authenticphysician: …
Sep 3, 2014 – Posts about Majid Ali MD written by Majid Ali MD. … far beyond the classical and wholly inadequate notion of it being a process characterized by edema, erythema, tenderness, pain, and infiltrate of inflammatory cells. ….. For reversing coronary artery disease one must become one’s own primary physician.

store.payloadz.com › Movies and Videos › Educational
Buy and Download > Description. In this 35-minute video seminar, Professor Majid AliM.D. explains why he rejects the diagnostic criteria for prediabetes established by the American Diabetes Association (ADA) and the World Health Organization (WHO). He asserts diabetes can neither be prevented nor reversed as long …

 


Top Seven for Diabetic Foot

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Dr. Ali’s Diabetes Diet Plan

 

Dr. Nutrients, Herbs, and Spices As Cellular Detergents

Majid Ali, M.D.


Two Golden Rules:
1. Start Low, Build Slow Rule
2. The Rotation Rule

As for the first rule, it is always prudent to test one’s own metabolic uniqueness by starting with a small dose, such as one-half of the dose in the guidelines and then gradually increase it to the full suggested dose when full clinical tolerance of the remedy has been assured.

The rotation in the second rule can be alternate days, two-days-on-one-day-off, or weekly.

 


Purpose of Supplements
To restore insulin function and regulate
blood glucose level by correcting insulin dyregulation.
restoring , the insulin receptor
protein in cell membranes needs to de-
greased with cellular detergents. 

 

To reverse pre-diabetes and diabetes (completely or partially), my primary objective is to lower both blood sugar and insulin levels by making insulin work better. For individuals with pre-diabetes with insulin toxicity but without high blood sugar levels, my goal is to lower blood insulin levels by increasing insulin efficiency.


Dr. Ali’s Diabetes Diet Plan

My Diabetes Reversal Plan has two components:

1. A plan of food choices to prevent sugar spikes that trigger insulin spikes, and

2. A plan to do daily gentle bowel and liver detox.

In the Table 2 below, I present a case study to show how blood glucose and insulin levels were lowered (by increasing insulin efficiency) with the clinical application of Dr. Ali’s Insulin Reduction Protocol. I follow this with some explanatory comments. In Table 1, I present the insulin and glucose values of an individual in good metabolic health.


Link to Dr. Ali’s Diabetes Diet Plan

https://alidiabetes.org/2018/02/05/dr-alis-diabetes-diet-plan/


 

 

Table 1. Insulin-conserving Profile of a 77-Yr-Old Metabolically Fit 5′ 5″ Man Weighing 133 Lbs. He Was Seen for Allergy Treatment.

6.23. 2010

Fasting

1 Hr

2 Hr

3 Hr

Insulin

<2

24

29

30

Glucose

78

96

75

71

Table 2. Concurrent Reduction of Blood Insulin and Blood Sugar Levels With Dr. Ali’s Insulin Reduction Protocol in a 58-Yr-Old Woman With Complete Loss of Hair (Alopecia), Chronic Fatigue, Memory Deficit, Underactive Thyroid Gland, Allergy, and Mood Swings.

10.28.10

Fasting

1 Hr

2 Hr

3 Hr

Insulin

9.7

184.4

35.3

24

Glucose

102

133

79

73

11.23.1202

Insulin

12.7

87.7

50.2

 

Glucose

96

117

77

 

Diabetes Reversal Requires a Philosophy of Healing

Diabetes Type 2 can be reversed neither with the denial of dieting nor with euphoria of eating. Diabetes can be reversed only with a philosophy of eating and living. It requires knowing the difference between being “diabetes-literate” and “healing-literate.” Diabetes is the number one cause of blindness, neuropathy, toe and limb amputations, kidney failure leading to dialysis, and increased risk of strokes, memory loss, and heart attacks. So reversing diabetes is an act of self-compassion. If these words pull you toward making an honest attempt to lose diabetes Type 2, please consider studying “Dr. Ali’s Course on Healing” (available at www.aliacademy.com).


Five Important Facts About Insulin-Wise and Insulin-Unwise Foods

I coined the terms Insulin-Wise and Insulin-Unwise Foods to raise consciousness about the serious adverse effects of insulin spikes on all cell populations in the body.

1. Insulin in excess (insulin toxicity) is fattening and inflaming.

2. Healthy fats are insulin-friendly.

3. Healthy proteins are insulin-friendly.

4. All breads, pastas, fruits and fruit juices, and sugars are insulin-unfriendly.

5. Vegetables are insulin-friendly.


Below are guidelines for Dr. Ali’s Insulin Diet. If initially this diet plan is found to be too hard and restrictive, one or two days a week may be taken as free days. Of course, some insulin benefits will be lost on such days.

Insulin-Friendly Breakfast for Saving Insulin and Preventing Diabetes

1. Please consider “Dr. Ali’s Breakfast” (protein shake described below) four or five days a week.

2.` Take eggs and vegetables for breakfast the remaining two days.

3. No fruit juices, breads, or toast.

Insulin-Friendly Lunch for Saving Insulin and Preventing Diabetes

1. Large salad with goat cheese, chicken, or fish. All the olive or sesame oil you wish.

2. Uncooked, steamed, or lightly stir-fried vegetables. All the olive or sesame oil you wish.

Mid-Afternoon Snack

Use four to six ounces of the Dr. Ali’s Breakfast shake (prepared in the morning and carried to work).

Insulin-Friendly Dinner for Saving Insulin and Preventing Diabetes

 

1. All healthy fats and oils

2. All healthy proteins

3. Uncooked, steamed, or lightly stir-fried vegetables with melted butter or olive oil (to your heart’s content).

Optimal Breakfast Choices for Diabetes

Dr. Ali’s Breakfast on five to six days per week comprising: (1) two tablespoons of a protein powder containing 85 to 90 percent calories in proteins and peptides; (2) two tablespoons of a granular lecithin; (3) two tablespoons of freshly ground flaxseed (the use of a coffee grinder is recommended); (4) 12 to 16 ounces of organic vegetable juice (avoiding or minimizing the use of carrots and red beets); and (5) 12 to 16 ounces of water. A few ounces of seltzer water or a few drops of lemon juice may be added to suit personal taste. I personally consume this mixture in portions of six to eight ounces with my morning nutrient and herbal protocols during the period of my morning exercise, meditation, and preparation for work. I have not yet encountered any negative impact of the protein content in this breakfast on renal function. Still, individuals with serum creatinine levels above the normal range need to be monitored for renal function.

Insulin Channel on YouTube Science, Health, and Healing Encyclopedia

I offer about 75 videos on insulin in health and disease on my my YouTube Science, Health, and Healing Encyclopedia. I especially recommend the channel entitled “Seven Faces of Insulin Toxicity”:http://www.youtube.com/watch?v=zxtVhe0mnf4

Insulin – the Minister of Energy and Metabolism

I designate insulin to be the Minister of Energy and Metabolism to the Oxygen king of the human body. By its signals, it regulates the energy of all cells in the body. Of necessity, this means that insulin has a role to play in the health preservation of all such cells.

Insulin is a hormone produced in specialized cells of the pancreas gland called beta cells. It is a string made up of 51 amino acid molecules and has a molecular weight of 5808 Daltons. Insulin performs diverse metabolic and non-metabolic functions in the body. As for metabolism, its major functions include the transfer of glucose from the blood into the liver and muscle cells for storage and into the fatty tissues to stop the use of fat as fuel. Among the major non-metabolic functions are its roles in cellular development, differentiation, and death.

Related Articles

 Oxygen Homeostasis and Oxygen Models of Diseases

* Insulin Homeostasis and Diabetes

* Insulin-Wise Foods, Insulin-Saving Recipes

* Dr. Ali’s Insulin Reduction Protocol – For Improving Insulin Efficiency

* Dr. Ali’s Insulin-Wise Breakfast

* Dr. Ali’s Insulin-Wise Breakfast – Personalized

* Insulin-saving Tuna-Tiki

* Insulin-saving Vege-Tiki

* Insulin-saving Palak-Tiki

* Insulin-saving Almond snack

 

 

Dr. Ali’s Supplement Plan for Diabetes Reversal

Majid Ali, M.D.

Cellular Detergents

Nutrient, Spices, Herbs, and Minerals as Cellular Detergents for Restoring Insulin Function and Reversing Diabetes


 

Plant Remedies (Phytofactors) for Diabetes

  1. Aloe Vera
  2. Bitter melon
  3. Cinnamon
  4. Fenugreek
  5. Flaxseed
  6. Garlic
  7. Ginseng (Panax ginseng)
  8. Gymnema sylvestre
  9. Huckelberry
  10. Neem
  11. Nopal (prickly pear cactus)

High Priority Nutritional Supplements for Reversing Diabetes

  1. Coenzyme Q10
  2. Chromium
  3. Lipoic acid (alpha lipoic)
  4. Magnesium, potassium, Taurine
  5. Cinnamon
  6. Chromium
  7. Vanadyl sulfate
  8. Multivitamin
  9. Multimineral

Dr. Ali’s Top Nutrients and Plant Remedies 

1. Magnesium, Potassium, and Taurine

2. Coenzyme Q 10 

3  Multiminerals (selenium, chromium, molybdenum, vanadium, manganese),

4. Multivitamins

5. Plant remedies

 


Magnesium, Potassium, and Taurine for Diabetes

I prescribe magnesium, potassium, and taurine for every patients when my goals are:

  1. For Reversing Diabetes
  2. For Insulin Detox for Long-term Results
  3. For Preventing Diabetes (T2D and Other Types)
  4. For a Healthy Life Span

Diabetes Reversal  With Diet and Insulin Detox.
Profiles of a 75-Yr-Old 5’2” Female Weighing 162 Lbs. Who Presented With Inhalant Allergy and Sinusitis
 April 2013
Fasting
½  Hr
1Hr
2Hr
3Hr
Insulin uU/mL
16
37
59
113
152
Glucose mg/mL 
      112  
  158    
   214
   241   
   155
April 2015
Insulin uIU/mL
6.2
22.1
42.9
51.2
39.7
Glucose mg/mL 
96    
130 
193
131
105    
A1c 5.9%

 

 Reversing Diabetes – Four Goals of the Patient 

R


Reversing Diabetes:

Four Steps for the Patients

Four Steps for the Physicians

Four Steps for the Patient

  1.                                  Love

  2.                                 Oxygen

  3.                                 Prayer

  4.                                 Insulin


 

Love provides the purpose of reversing diabetes.

Prayer provides the path to that purpose.

Oxygen orchestrates the bodily functions that prevent and reverse diabetes.

Insulin is the master energy hormone for preventing and reversing diabetes.


 

The Reversing Diabetes Path

The Path to Healing Is the Path to Peace.

The Path to Peace Is the Path to the Spiritual.

The Path to the Spiritual Is the Path Away From the Self.

The Path Away from the Self Is the Path to One’s Own Divinity, to Oneness With Divinity.

The Path to That Oneness Is the Path to Insulin Solutions, and Freedom from Diabetes and Its Suffering.


 

Four Steps for the Physician

My top four goals for reversing diabetes and clearing insulin toxicity (hyperinsulinism) are the same as they for all other chronic diseases. Specifically, they are:

1. Oxygen signaling

2. Gut ecology

3. Insulin signaling

4. Truth and best effort


 

For my patients on the Path Away From Diabetes, I

  • Promise no results,
  • Promise total honesty, and
  • Promise best effort.

 

An Important Link for the Path

http://www.insulininstitute.org/dr__a__insulin_protocol_a.htm

Other important links for knowing the path, please go to my video library near the end.


Plant Remedies and Supplements

for Reversing Hyperinsulinism (Prediabetes) and Diabetes

Phytofactors (Plant Remedies) 

  1. Aloe Vera
  2. Bitter melon
  3. Cinnamon
  4. Fenugreek
  5. Flaxseed
  6. Garlic
  7. Ginseng (Panax ginseng)
  8. Gymnema sylvestre
  9. Huckelberry
  10. Neem
  11. Nopal (prickly pear cactus)

Nutritional Supplements

  1. Coenzyme Q10
  2. Chromium
  3. Lipoic acid (alpha lipoic)
  4. Magnesium, potassium, Taurine
  5. Cinnamon
  6. Chromium
  7. Vanadyl sulfate
  8. Multivitamin
  9. Multimineral

Top Priorities for Nutrients and Plant-Based Remedies

1. Magnesium, Potassium, and Taurine

2. Calcium-magnesium

3  Multiminerals (selenium, chromium, molybdenum, vanadium, manganese),

4. Multivitamins

5. Plant-based remedies

 


Magnesium, Potassium, and Taurine

I prescribe magnesium, potassium, and taurine for every patients when my goals are:

  1. To reverse diabetes
  2. To clear insulin toxicity of hyperinsulinism
  3.  To prevent complications of Type 2 diabetes
  4. To  alter the course of other types of diabetes.

 

Magnesium, Do Not Forget To Take It, Please! Majid Ali MD on Vimeo

https://vimeo.com › Majid Ali › Videos

Magnesium, Do Not Forget To Take It, Please! Majid Ali MD. 3 years ago More.Majid AliPRO. Follow. 0 …

How Much Magnesium Do I Take Majid Ali MD on Vimeo

https://vimeo.com › Majid Ali › Videos

How Much Magnesium Do I Take Majid Ali MD. from Majid AliPRO 3 years ago. Follow. 0 0. Download Share …

Magnesium and the Heart – Dr. Ali’s Virtual Medical Library

drali1.org/magnesium_and_heart.htm

Magnesium and the Heart. Majid Ali, M.D.. A large body of data showing a relationship between low dietary intake of magnesium and the incidence of cardiac …

Healing Foods by Majid Ali, MD Note: The … Soybean: is an excellent source of minerals such as magnesium, calcium, molybdenum and others. It is rich in …Magnesium and the Heart – Dr. Ali’s Virtual Medical Library

drali1.org/magnesium_and_heart.htm

Magnesium and the Heart. Majid Ali, M.D.. A large body of data showing a relationship between low dietary intake of magnesium and the incidence of cardiac …


 

Magnesium Content of Foods | The Ali Academy Community

Jun 20, 2014 – Magnesium, The Miracle Mineral Majid Ali, M.D. Magnesium is an … I liberally prescribepotassium and magnesium supplementation for all my …


Your Kidney’s New Year Resolution | Renal Health | The Ali Academy …

Dec 29, 2014 – The kidneys help keep the right amount of potassium in the body. … Potassium, Sodium, and Neurotransmission Majid Ali MD – …

Dr. Ali Expains How Minerals Beat Fatigue | The Ali Academy …

Jun 1, 2014 – Minerals: Your Body’s Energy Sparks Majid Ali, M.D. There are two types of … Potassium, Sodium, and Neurotransmission Majid Ali MD – …

How Much Potassium Do I Take Majid Ali MD on Vimeo

https://vimeo.com › Majid Ali › Videos

Join · Log in · Host videos · Compare plans · Professionals · Businesses · Video lovers · Video School …

Dr. Ali’s Spicy Potassium Lemonade – Majid Ali, MD on Vimeo

https://vimeo.com › Majid Ali › Videos

This is “Dr. Ali’s Spicy Potassium Lemonade – Majid Ali, MD” by Majid Ali on Vimeo, the home for high …

Dr. Ali’s Potassium Lemonade – Majid Ali, MD on Vimeo

https://vimeo.com › Majid Ali › Videos
Aug 7, 2014

This is “Dr. Ali’s Potassium Lemonade – Majid Ali, MD” by Majid Ali on Vimeo, the home for high quality …


Taurine

A free course on Liver Health NOW | Majid Ali MD | The Ali Academy …

Nov 28, 2014 – Inflammation and Liver – Majid Ali, MD ….. methylsulfonylmethane (MSM, 750 to 1,500 mg); taurine (750 to 1,500 mg); and antioxidant vitamins.

Taurine – Majid Ali, MD on Vimeo

https://vimeo.com › Majid Ali › Videos
Apr 23, 2014

Professor Majid Ali shares information about “Taurine

Ali Healing Community

Majid Ali, M.D Misinformation about the science of health, eating depleted … Why do I commonly prescribe magnesium, potassium, and taurine for most of my …

Majid Ali MD | – alihealing.org

Read all of the posts by Majid Ali MD on. … Why do I commonly prescribe magnesium, potassium, andtaurine for most of my patients with chronic disease in my …

Integrated Magnesium Therapy – Who Is Dr. Ali?

Aug 3, 2017 – Majid Ali, M.D. I liberally prescribe integrated magnesium … magnesium prescriptions nearly always include potassium, calcium, and taurine.

 


 


Vitamin B6 for Preventing and Reversing Gestational Diabetes

Vitamin B 6 in its Pyridoxal-5-phosphate (P5P) form can be rightfully considered a nutrient of choice for preventing and reversing gestational diabetes. Simply stated, this is how it works:

  1. Xanthourenic acid (XA) is a metabolite of tryptophan(which is used to produced melatonin and serotonin)
  2. Women who are more vulnerable to gestational diabetes seem to have altered enzymatic function so tryptophan is readily turned into xanthourenic but not so readily into melatonin and serotonin.
  3. Excess xanthourenic acid binds with insulin and blocks metabolic functions of insulin in lowering blood glucose level setting the stage for gestational diabetes..
  4. Women who are more vulnerable to gestational diabetes seem to have altered enzymatic function so tryptophan is readily turned into xanthourenic but not so readily into melatonin and serotonin.
  5. Very high estrogen levels during pregnancy also seem to play a role.

 

 

Top Priority Nutrients for Reversing Diabetes By Clearing Insulin Toxicity

Majid Ali, M.D.   Top Priorities for Nutrients and Plant-Based Remedies  1. Magnesium, Potassium, and Taurine 2. Calcium-magnesium 3  Multiminerals (selenium, chromium, molybdenum, vanadium, manganese, 4. Multivitamin   …

What Is Empirical Healing?

Majid Ali, M.D. All healing is energy healing. Since humans began to look for ways to deal with illness, it sought therapies that worked and were safe. In earlier times, safe and effective therapies were not discarded ju…

Dr. Ali’s Insulin Library

Majid Ali, M.D. My Oxygen Thinking Has Given Me Insights About the Roles of Insulin in Health and Disease which Robustly Challenge the Prevailing Notions of Insulin, Insulin Resistance, and Hyperinsulinism.    Large Clai…

Not Moving Away From Diabetes Is Moving Towards It

  Majid Ali, M.D. Insulin toxicity and diabetes have eclipsed All Chronic Diseases Worldwide. I am grateful to my Patients (My Truest Teachers) Who Helped Me Recognize This Disturbing Reality.    Insulin Essentials Insul…

Insulin Essentials

Majid Ali, M.D. Very little of What I Learned About Diabetes In Medical School Has Been Validated by My Patients, My True Teachers.   Insulin Essentials Insulin is the master energy hormone of the body, for energy genera…

Reversing Diabetes D3 – Part A: The Diet Plan

Majid Ali, M.D. A Simplified Yet Effective Choices in-the-Kitchen Part of Reversing Diabetes D3 Plan for Preventing and Reversing Diabetes Based on Authentic Science and Philosophy of Holism    Reversing  Diabetes D3    …

Diabetes and Insulin Library

Majid Ali, M.D. A Comprehensive Library of the Science and Philosophy of Holism For Preventing and Reversing Diabetes    Diabetes Reversal With Insulin Detox | Ali Diabetes https://alidiabetes.org/category/diabetes-rever…
Majid Ali, M.D. Alzheimer’s Disease Before the Supreme Court of Science – 2017     Alzheimer’s Before the Supreme Court of Science – 2017 I have subscribed and read the journal Nature over 25 for years. It is a journal o…
Three Stages of Diabetes
Majid Ali, M.D. Do You Know Which One of the Three Stages of Diabetes You Are In? Why That Is Important?   You can Learn This Only With Blood Insulin Test. Diabetes In Hyperinsulinism Stage With High Blood In…
  • Should A1c Tests Be Used for Screening for Diabetes? No.

Majid Ali, M.D. Insulin and Glucose Profiles of Reversing Diabetes D3 Series     The blood A1c test is an excellent test for monitoring the results of diabetes treatment, but it is not reliable for screening for diabetes…

 

 

 

 

 

 

 

REVERSING DIABETES – LESSON FOUR

 

Majid Ali, M.D.

Supplentation Guidelines for Reversing Diabetes

Integrated Nutrient, Spice, and Herb Plan


Celebrating Small Successes, Not Sweating Small Missteps.

A Component of Holistic and Integrated Science and Philosophy of Reversing Diabetes


The Golden Begin-Low Build-Slow Principle

Do Not Take All Items In These Guidelines On the first day. 

In all guidelines for preserving health and reversing chronic disease with natural remedies, I strongly suggest that  readers to consider my Golden Start-Low-Build-Slow Principle. Simply stated, this principle requires that an individual, in trying natural remedies, be cautious and closely observe how the body responds to natural remedies, beginning with small amounts or portions (as low as one-tenth the value on the first day, and doubling them every day until the recommended amount is reached.) If any negative senses are experienced, the item should be discontinued for several days or be taken in smaller amounts for longer periods of time to increase tolerance. It is important that a doctor be consulted to rule out the presence of serious coexisting or underlying conditions.


Family healing work, first and foremost, has to be fun, each member moving on a personal pace. Pushing and brow-beating does not work in the long run, learning and knowing does. Long-term results require a philosophy of love and healing. So, again we celebrate small successes and not sweat missteps.


Reversing Diabetes – Lesson One Includes the Following:

  • Diabetes is not a sugar problem
  • Two examples of healthy insulin and glucose (sugar) profiles
  • One example of insulin and glucose profiles of an individual with diabetes, before and after diabetes reversal
  • What is insulin intelligence?
  • Metabolic Actions of Insulin Hormone
  • How does insulin toxicity (hyperinsulinism) develop)?
  • Oxygen Model of Insulin Toxicity

Five-Step Plan for Reversing Diabetes

  1. A plan of food choices to prevent sugar spikes that trigger insulin spikes;
  2. A plan to do daily gentle bowel and liver detox;
  3. A program of oxygen-stabilizing spices, herbs, and nutrients;
  4. A program of non-competitive Limbic Exercise; and
  5. A personal goal of self-compassion

 

Guidelines for Special Remedies for Reversing Diabetes.

Please Do Not Take Every Item on the First Day.

Any item not tolerated well should be withheld for three weeks and tried again.

Reversing Diabetes Special Group One

  1. Chromium 50 – 75 mcg
  2. Gymnema Sylvestre 750 -1000 mg
  3. Huckleberry 100 -150 mg
  4. Neem 50 – 75 mg
  5. Vanadyl sulfate 20 – 30 mg

Reversing Diabetes Special Group Two

  1. Cinnamon ½ – ¾ teaspoon
  2. Fennel Seeds ½ teaspoon, chewed or as tea
  3. Fenugreek ½ teaspoon, chewed or as tea
  4. Cumin 1/6 -1/10 teaspoon
  5. Cloves 1/6 – 1/10 teaspoon

Guidelines for Mineral Supplementation

  1. Magnesium                            750-1000 mg
  2. Calcium                                   300- 500 mg
  3. Zinc                                         10-15       mg
  4. Copper                                    1-2           mg
  5. Selenium                                400-600   mcg
  6. Chromium                             100-150   mcg
  7. Molybdenum                         75-100     mcg
  8. Iodine                                      50-75       mcg
  9. Manganese                             5-7.5          mg

Balanced Multivitamin Formula

  1. Vitamin A                                 2500 IU
  2. Beta carotene                         2500 IU
  3. Vitamin B 1, B2, B6               30 mg
  4. Niacinamide                           150 mg
  5. Pantothenic acid                   250 -500 mg
  6. Pyridoxic B 5                        25-50 mg
  7. Folic acid                               300-500 mcg
  8. Choline bitartrate               400 mg

 

Diabetes Video Library

Who Is Dr. Ali?

https://vimeo.com/100034154


Reversing Diabetes – Lesson One

https://alidiabetes.org/2016/07/31/reversing-diabetes-lesson-one/

Reversing Diabetes – Seven Simple Lessons

https://alidiabetes.org/2015/12/06/diabetes-prevention-and-reversal-seven-simple-lessons/


Diabetes Recipes

https://alidiabetes.org/2016/07/25/recipes-for-insulin-detox-and-diabetes-reversal/

  1. ALI’S 3-PART DIABETES COURSE – PART THREE

https://alidiabetes.org/2016/07/25/dr-alis-3-part-diabetes-course-part-three/

ALI’S 3-PART DIABETES COURSE PART TWO

https://alidiabetes.org/2016/07/11/dr-alis-diabetes-course-part-two/


 

Insulin Videos

 What Is Insulin? What Are Its Functions?

https://vimeo.com/151438318

 Insulin Detox for Wight Loss and Diabetes Reversal

 I’m Hungery After Meals. Why?

https://vimeo.com/151438394

 


What is Diabetes

https://www.youtube.com/watch?v=vTUFY2It-vQ

Insulin Toxicity De-mystifies Syndrome X

https://www.youtube.com/watch?v=j329lYfBQxQ


Don’t Trust A1c for Diabetes Diagnosis, Please!

https://www.youtube.com/watch?v=-znFd2F0NaE

 Recipes for Insulin Toxicity – Majid Ali, MD

 https://vimeo.com/92696716

 Almond Butter Snack for Losing Weight and Reversing Diabetes, An Excellent Choice

https://vimeo.com/151438553


 Peanut Butter or Hemp Seed Butter Peanut Butter Snack for Weight Loss and Diabetes Reversal

https://vimeo.com/151438438

https://vimeo.com/151438252

 

 

Dr. Ali’s Insulin Course, Basics

https://vimeo.com/151438736

 

What Is the Problem With Calorie Counting?

https://vimeo.com/151438675

Is a Calorie a Calorie a Calorie?

https://vimeo.com/151438813

 Is Insulin Excess Bad for the Heart?

https://vimeo.com/151436418


 What Is Diabetes? Majid Ali, M.D. With Ben Svoboda

https://vimeo.com/150396100

 Is Excess Insulin Toxic to Nerves

https://vimeo.com/151438702


 

 

 

 

Majid Ali, M.D. – Is a Calorie a Calorie a Calorie?

https://vimeo.com/151438813

 

I’m Hungry After Meals. Why?

https://vimeo.com/151438394

 

 

Recipes for Insulin Toxicity – Majid Ali, MD

 

https://vimeo.com/92696716

 

 

Almond Butter Snack for Losing Weight and Reversing Diabetes, An Excellent Choice

https://vimeo.com/151438553

 

 

Peanut Butter or Hemp Seed Butter Peanut Butter Snack for Weight Loss and Diabetes Reversal

https://vimeo.com/151438438

 

 

 

 

 

 

 

Diabetes and insulin Majid Ali MD

https://vimeo.com/90230647

 

Why Do I Consider Blood Insulin Test to be the Single Most Important Test

https://vimeo.com/132580419

 

What Is Your Child’s Peak Insulin Level? Is She or He Insulin-Toxic?

https://vimeo.com/107155876

 

 

 

Insulin Buddy and Fatty Liver

https://vimeo.com/117652486

 

 

What is the Evidence That Neuropathy Is Caused by Insulin Toxicity?

https://vimeo.com/118455458

 

Obesity Is Cellular Inflammation

https://vimeo.com/119094041

 

 

Dr. Ali’s Best AntiDiabetes Breakfast

https://vimeo.com/131388294

 

 

Gestational Diabetes Is Insulin Toxicity of the Unborn – Part Two

https://vimeo.com/117703033

Your Child – Hyperactive or Hypoglycemic?

https://www.youtube.com/watch?v=ruAmaafBThM

 

Why Do I Consider Blood Insulin Test to be the Most Important Test for Metabolism and Diabetes

https://www.youtube.com/watch?v=xjv48fanxl0

 

MMM

 

Muslim Moms, Drone Democracies,

 

 

https://alihealing.org/2016/07/10/muslim-moms-and-drone-democracies/

 

 

Healing-in-Mirror Part One

 

https://mail.aol.com/webmail-std/en-us/suite

 

 

 

 

 

 

https://alihealing.org/2016/06/18/why-are-lies-complicated-and-truth-simple/

 

 

 

https://alihealing.org/why-are-lies-complicated-and-truth-simple/

 

 

History of Diabetes

https://alidiabetes.org/2016/06/27/history-of-diabetes/

 

Links to Recipes for Insulin Detox and Diabetes Reversal

 

https://alidiabetes.org/2016/07/25/recipes-for-insulin-detox-and-diabetes-reversal/

 

 

 

https://alidiabetes.org/recipes-for-insulin-detox-and-diabetes-reversal/

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