Category Archives: 3D Insulin Protocol

Insulin- Wise Eating

Majid Ali, M.D.

Insulin-Wise Eating

For Improving Insulin Efficiency


Insulin-Wise Eating

For Improving Insulin Efficiency

Updated Jan. 16, 2018

Majid Ali, M.D.

 

To reverse pre-diabetes and diabetes (completely or partially), my primary objective is to lower both blood sugar and insulin levels by making insulin work better. For individuals with pre-diabetes with insulin toxicity but without high blood sugar levels, my goal is to lower blood insulin levels by increasing insulin efficiency.

Dr. Ali’s Insulin Normalization Plan

My Insulin Reduction Protocol has three components:

  1. A plan of food choices to prevent sugar spikes that trigger insulin spikes, and
  2. A plan to do daily gentle bowel and liver detox.
  3. A Plan for Spiritual Surrender

In the Table 2 below, I present a case study to show how blood glucose and insulin levels were lowered (by increasing insulin efficiency) with the clinical application of Dr. Ali’s Insulin Reduction Protocol. I follow this with some explanatory comments. In Table 1, I present the insulin and glucose values of an individual in good metabolic health.

 

Table 1. Insulin-conserving Profile of a 77-Yr-Old Metabolically Fit 5′ 5″ Man Weighing 133 Lbs. He Was Seen for Allergy Treatment.
6.23. 2010 Fasting 1 Hr 2 Hr 3 Hr
Insulin <2 24 29 30
Glucose 78 96 75 71

 

Table 2. Concurrent Reduction of Blood Insulin and Blood Sugar Levels With Dr. Ali’s Insulin Reduction Protocol in a 58-Yr-Old Woman With Complete Loss of Hair (Alopecia), Chronic Fatigue, Memory Deficit, Underactive Thyroid Gland, Allergy, and Mood Swings.
10.28.10 Fasting 1 Hr 2 Hr 3 Hr
Insulin 9.7 184.4 35.3 24
Glucose 102 133 79 73
11.23.1202
Insulin 12.7 87.7 50.2  
Glucose 96 117 77  

Diabetes Reversal Requires a Philosophy of Healing

Diabetes Type 2 can be reversed neither with the denial of dieting nor with euphoria of eating. Diabetes can be reversed only with a philosophy of eating and living. It requires knowing the difference between being “diabetes-literate” and “healing-literate.” Diabetes is the number one cause of blindness, neuropathy, toe and limb amputations, kidney failure leading to dialysis, and increased risk of strokes, memory loss, and heart attacks. So reversing diabetes is an act of self-compassion. If these words pull you toward making an honest attempt to lose diabetes Type 2, please consider studying “Dr. Ali’s Course on Healing” (available at www.aliacademy.com).


 

Five Important Facts About Insulin-Wise and Insulin-Unwise Foods

I coined the terms Insulin-Wise and Insulin-Unwise Foods to raise consciousness about the serious adverse effects of insulin spikes on all cell populations in the body.

  1. Insulin in excess (insulin toxicity) is fattening and inflaming.
  2. Healthy fats are insulin-friendly.
  3. Healthy proteins are insulin-friendly.
  4. All breads, pastas, fruits and fruit juices, and sugars are insulin-unfriendly.
  5. Vegetables are insulin-friendly.

Simply stated, Insulin-Wise foods facilitate insulin signals and other functions, while Insulin-Unwise foods impede or block insulin signals and other functions. I present this subject at length in my book entitled “Dr. Ali’s Plan for Reversing Diabetes” and in a 40-minute video seminar that can be downloaded from www.aliacademy.org or by calling 1-800-633-6226.

Below are guidelines for Dr. Ali’s Insulin Diet. If initially this diet plan is found to be too hard and restrictive, one or two days a week may be taken as free days. Of course, some insulin benefits will be lost on such days.

Insulin-Friendly Breakfast for Saving Insulin and Preventing Diabetes

  1. Please consider “Dr. Ali’s Breakfast” (protein shake described below) four or five days a week.

2.` Take eggs and vegetables for breakfast the remaining two days.

  1. No fruit juices, breads, or toast.

Insulin-Friendly Lunch for Saving Insulin and Preventing Diabetes

  1. Large salad with goat cheese, chicken, or fish. All the olive or sesame oil you wish.
  2. Uncooked, steamed, or lightly stir-fried vegetables. All the olive or sesame oil you wish.

Mid-Afternoon Snack

Use four to six ounces of the Dr. Ali’s Breakfast shake (prepared in the morning and carried to work).

Insulin-Friendly Dinner for Saving Insulin and Preventing Diabetes

  1. All healthy fats and oils
  2. All healthy proteins
  3. Uncooked, steamed, or lightly stir-fried vegetables with melted butter or olive oil (to your heart’s content).

Optimal Breakfast Choices for Diabetes

Dr. Ali’s Breakfast on five to six days per week comprising: (1) two tablespoons of a protein powder containing 85 to 90 percent calories in proteins and peptides; (2) two tablespoons of a granular lecithin; (3) two tablespoons of freshly ground flaxseed (the use of a coffee grinder is recommended); (4) 12 to 16 ounces of organic vegetable juice (avoiding or minimizing the use of carrots and red beets); and (5) 12 to 16 ounces of water. A few ounces of seltzer water or a few drops of lemon juice may be added to suit personal taste. I personally consume this mixture in portions of six to eight ounces with my morning nutrient and herbal protocols during the period of my morning exercise, meditation, and preparation for work. I have not yet encountered any negative impact of the protein content in this breakfast on renal function. Still, individuals with serum creatinine levels above the normal range need to be monitored for renal function.

Insulin Channel on YouTube Science, Health, and Healing Encyclopedia

I offer about 75 videos on insulin in health and disease on my my YouTube Science, Health, and Healing Encyclopedia. I especially recommend the channel entitled “Seven Faces of Insulin Toxicity”: http://www.youtube.com/watch?v=zxtVhe0mnf4

Insulin – the Minister of Energy and Metabolism

I designate insulin to be the Minister of Energy and Metabolism to the Oxygen king of the human body. By its signals, it regulates the energy of all cells in the body. Of necessity, this means that insulin has a role to play in the health preservation of all such cells.

Insulin is a hormone produced in specialized cells of the pancreas gland called beta cells. It is a string made up of 51 amino acid molecules and has a molecular weight of 5808 Daltons. Insulin performs diverse metabolic and non-metabolic functions in the body. As for metabolism, its major functions include the transfer of glucose from the blood into the liver and muscle cells for storage and into the fatty tissues to stop the use of fat as fuel. Among the major non-metabolic functions are its roles in cellular development, differentiation, and death.

Related Articles

 Oxygen Homeostasis and Oxygen Models of Diseases

* Insulin Homeostasis and Diabetes

* Insulin-Wise Foods, Insulin-Saving Recipes

* Dr. Ali’s Insulin Reduction Protocol – For Improving Insulin Efficiency

* Dr. Ali’s Insulin-Wise Breakfast

* Dr. Ali’s Insulin-Wise Breakfast – Personalized

* Insulin-saving Tuna-Tiki

* Insulin-saving Vege-Tiki

* Insulin-saving Palak-Tiki

* Insulin-saving Almond snack

The Diabetes Question

Majid Ali, M.D.

Does Diabetes Begin As a Rising Blood Sugar Disease Or As a Rising blood Insulin Disease?

We Will Let Call It  

The Diabetes Question.


If the answer to the diabetes question is that it begins with rising blood insulin levels,  not with rising blood glucose levels, then the following new questions arise?

Question: Is excess insulin (hyperinsulinism) toxic to the body organs?

Answer, Yes, Excess insulin is fattening, fermentiing, and inflaming. It swells the liver and shrinks the brain. It is pro-cancer, pro-inflammation, and pro-degenerative diseases. In damages endo cells which lines the inside of the entire cardiovascular system and affects blood circulation everywhere in the body. Simply stated, excess insulin (insulin toxicity) is “pro-accelerated pro-aging.” 

Question: Can insulin toxicity be assessed with blood sugar tests?

Answer. No.

Question: In most people, how long does insulin toxicity go on undetected before blood sugar levels rise enough to make diabetes diagnosable with blood sugar tests?

Answer, for five, ten, or more years?

Question: Do doctors usually always test for blood insulin level before they test for blood sugar level?

Answer, No.


 

What Must Be Known About Crucial Diabetes and Its Complications

(In this article the terms diabetes and Type 2 dabetes are used interchangeably)

Diabetes (Type 2 Diabetes,T2D) Cannot Be Diagnosed In Time Without Insulin Tests, Diabetes Cannot Be Reversed Without Insulin Intelligence. Nor Can Diabetes Complications Be Prevented or Reversed Without Insulin Intelligence.


 

Summary

Diabetes Is Not a Sugar Problem,

It Is a Problem of Insulin Toxicity (Hyperinsulinism).

Insulin Toxicity Predates Diabetes by Five, Ten, or more Years, and Directly Leads to the Disease.


 

The Cost of Neglected Insulin Testing 

Hyperinsulinism (insulin toxicity) inflicts cellular injury in nearly all cellular populations in the body.  During the  years insulin toxicity remains ,undetected and untreated, simply because insulin testing is neglected by practitioners. Why?

Blood insulin testing is not considered a standard of care by those who control $1.3 trillion yearly spending for medical care in the United States. After considering the evidence I present in this and other articles in my “Diabetes Question Series,” the readers will decide for themselves as to the real reason for neglected insulin testing.  

I Leave the answer to readers.    


What Is Insulin Intelligence?

Simply stated, excess insulin (insulin toxicity and hyperinsulinism by other names)  is a fire which burns all parts of the body. It may start in different places and spread differently but the end result is always shortened life span with different diseases.

A practitioner who answers this questions with the “diabetes-hyperinsulinism” prevailing view does not, in my opinion, serve his patients well. Anyone who answers the question with one-liners recognizing insulin as the “life-span” hormone without does not deserve anyone’s time. As for me, I want to invite you to consider these questions by taking my free-of-cost course at this web site. A library of my selected article, published papers, and short videos is included in this post. Readers interested in my book on reversing diabetes and video seminar downloads can access these materials at http://www.aliacademy.org.


 

The Diabetes Question:

Can insulin regulation be assesses with sugar tests?

Specifically, can diabetes be detected in time with fasting blood sugar test, A1c blood tests, two-hour post prandial (after a meal) blood sugar level?

The answer: Categorically not.


 

What Is Optimal Insulin Homeostasis?

First, when the blood insulin levels after a glucose challenge are quite low;

Second, blood glucose after a glucose challenge are within low physiologic range.

Third, when there is no history of diabetes in parents and grandparents.

Fourth, when there is no insulin toxicity.

Fifth, when the immune system is robust and there is no chronic . immune-inflammatory disease.

Question: Can one optimize one’s insulin homeostasis? One can only answer this question for oneself.


 

One can tell oneself lies, but nature does not grant permission to believe one’s own lies. 


Can insulin homeostasis (insulin regulation as a whole) be assessed with blood sugar tolerance  test, A1c blood tests, two-hour post prandial (after a meal) blood glucose tests, as for instance the tolerance test done for gestational diabetes?

The answer: Categorically not.


To provide a broader context for due deliberation of the above questions, please consider sets of blood insulin and glucose profiles below which were prepared with fasting and timed post-glucose challenge.
       Table  1  Control Profiles
       Table 2,3 Blood glicose tests are inappropriate for assessing insulin homestasis
       Table 4.  Hyperinsulinism in Autism Spectrum Disorder 

Table 1. Two Sets of Control Insulin and Glucose Profiles

1.Healthy control subject:. Case 1.

                 INSULIN :    <2 uIU/mL, 18, uIU/mL, 4,       and <2;    

                 GLUCOSE:    77, 168, 109, 74, 52.

2. Healthy Control Subject: Case 2  

               INSULIN :    3 uIU/mL, 11, uIU/mL, 7,   and <2;    

               GLUCOSE:    81  157, 98, 63, 52.


The Challenge in Reversing Diabetes

is not to know what any doctor thinks about diabetes and drugs used to treat diabetes but how to learn to think for yourself about insulin, health, and healing.

I suggest you spend time at http://www.alidiabetes.org 


The Most Important Question in the Prevention and Reversal of Diabetes (Type 2)

No question is more important for stemming the global tides of insulin toxicity and diabetes than the question in the title of this post.


The Answer:

Insulin levels rise first, usually by five, ten, or more years before blood sugars level rise.
Why is this important?
Because insulin toxicity continues to cause cellular damage in the liver, kidneys, heart, brain, eyes and other organs unknown to the patient and the doctor if insulin tests are not done. For more info, go to http://www.Ali Diabetes.Org for the author’s free-access course at
http://www.Ali Diabetes.Org.

https://wordpress.com/post/alidiabetes.org/2966


Table 2. Insulin Homeostasis Categories in 506 Study Subjects Without Type 2 Diabetes
Insulin Category*
Percentage of Subgroup
Mean Peak Glucose  mg/dL
(mmol/mL)
Mean Peak Insulin (uIU/mL)
Exceptional Insulin Homeostasis.N 12**
1.7%
110.2     (6.12)
14.3
Optimal Insulin Homeostasis N =126
24.9 %
121.2     (6.73)
26.7
Hyperinsulinism, Mild                N =197
38.9 %
136.5   (7.58)
58.5
Hyperinsulinism,  Moderate       N =134
26.5 %
147.0    (8.16)
109.1
Hyperinsulinism,  Severe             N =  49
9.7 %
150.0    (8.33)
(less than time and a half higher) 
231.0
(nearly 17 times higher)
#   Correlation coefficient, r value, for means of peak glucose and insulin levels in the five insulin categories is 0.84.
  *Criteria for classification: (1) Exceptional insulin homeostasis, a subgroup of optimal insulin homeostasis with fasting insulin concentration of <2 uIU/mL and mean peak insulin concentration of <20; (2) optimal insulin homeostasis, peak insulin <40 accompanied by unimpaired glucose tolerance; (3) mild insulin homeostasis, peak insulin  between <40 and 80 uU/mL;  accompanied by unimpaired glucose tolerance; ; (3) moderate insulin homeostasis, peak insulin  between <80 uU/mL and 160 uIU/mL accompanied by unimpaired glucose tolerance;  and (4) severe insulin homeostasis, peak insulin  > 160 uU/mL accompanied by unimpaired glucose tolerance.

Why Do Diabetics Need Insulin Shots?

Because Their Pancreas Has Exhausted Its Lifetime Capacity of Produce Sufficient Insulin

Note the extremely high blood insulin level (298 uIU/mL) still cannot keep the blood glucose level in the normal non-diabetic level.
Table 3. Insulin Homeostasis Categories in 178 Study Subjects With Type 2 Diabetes.
Insulin Category
Percentage of Subgroup
Mean Peak Glucose, mg/dL
(mmol/mL)
Mean Peak Insulin (uIU/mL)
Diabetic Hyperinsulinism, Mild              N =  53
29.0%
252.0   (14.00)
55.4
Diabetic Hyperinsulinism, Moderate    N =  42
24.0%
242.1   (13.45)
112.4
Diabetic Hyperinsulinism, Severe          N =  24
13.9%
224.6   (12.47)
298.0
Diabetic  Insulin Deficit                             N =  59
33.1%
294.0    (16.33)
22.9

What Is Optimal Insulin Homeostasis?

It is the lowest blood insulin levels that can keep the blood glucose levels in the normal range.
In other words, It is ideal state of insulin utilization, in which insulin toxicity does not exist, nor is insulin wasted because there is too much of it in the blood.
is not wasted .
In 2017, in a large survey of insulin and glucose profiles in the general New York metropolitan population, my colleagues and I reported a hyperinsulinism prevalence of 75.1%. Below is the link to get free access to the full text of this report:

http://www.townsendletter.com/Jan2017/insulin0117.html

Or, you may get the report on this website by entering , please use the the following words on the search box of the site:  “Shifting Focus from Glycemic Status.”

Examples of Insulin and Glucose Profiles of Individuals With Perfect Insulin Regulation

Table 1. Post-Glucose Load Insulin and Glucose Profiles of Seven Individuals With Optimal Insulin Homeostasis as Defined Above.
Fasting
½-Hr
1-Hr
2-Hr
3-hr
Insulin Profile 1. Insulin And Glucose Profiles of a 47-yr-old 5′ 5″ Male Runner Weighing 130 lbs. Who Presented With Inhalant Allergy and Hemorrhoids.
Insulin uIU/mL
1.5
9.7
9.0
4.6
<1.0
Glucose mg/dL
72
148
134
108
54
Insulin Profile 2. Insulin and Glucose Profiles of a  45-Yr-Old  5’9″Man Weighing 125 lbs. Presenting With Allergy and Dry Skin.
Insulin uIU/mL
1.0
2.7
9.8
2.7
<1.0
Glucose mg/dL
85
110
75
70
52
Insulin Profile 3. Insulin and Glucose Profiles of a 51-year-old 5’6″ Man Weighing 120 lbs. He Consulted Me for Cardiac Rhythm Disorder, Hypothyroidism and  Allergy.
Insulin uIU/mL
2.9
6.0
11.5
2.5
Glucose mg/dL
89
103
134
110
59
Insulin Profile 4. Insulin and Glucose Profiles of a 52-Yr-Old 5’1″ Woman Weighing 120 lbs. Presenting With Constipation and  Allergy.
Insulin uIU/mL
<2
17
15
6
Glucose mg/dL
78
61
72
71
Insulin Profile 5. Insulin and Glucose Profiles of a  52-Yr-Old 5’ 7″ Man Weighing 155 lbs. Presenting With Anxiety, Depression, and Diarrhea. A1c. 5.3%
Insulin uIU/mL
2.0
8.1
19.6
17.7
4
Glucose mg/dL
94
140
158
91
73
Insulin Profile 6. Insulin and Glucose Profiles of a  62-Yr-Old  5’3″ Woman Weighing 114 lbs. Presenting With Allergy and Hand Arthralgia.
Insulin uIU/mL
1.8
17.8
11.0
10.0
Glucose mg/dL
80
159
76
75
68
Insulin Profile 7. Insulin and Glucose Profiles of a 51-year-old 5’2″ Woman Weighing 120 lbs. She Consulted Me for Hypothyroidism and  Allergy
Insulin uIU/mL
3.2
11.8
2.4
1.9
Glucose mg/dL
86
110
75
70
52
Insulin Lab Reference Ranges Not  Fit for Use
In a previous report the author and his colleagues have highlighted the serious problem of inappropriate prevailing reference ranges for blood insulin concentrations.13 The data in Table 2 reproduced from that publication dramatically illustrates the dimension of this problem with findings of a survey of major laboratories in the New York City metropolitan area. The study data also calls into question the clinical value of single and random blood insulin test results. Photographs of illustrative lab reports are posted online.14

Absurd Laboratory Reference Ranges

Table 2. Upper and Lower Limits of Laboratory Insulin Reference  Ranges Expressed In uIU/mL Following a Standard Glucose Load From Six Major Clinical Laboratories in the New York Metropolitan Area.2
Laboratory
Fasting
1 Hr
2 Hr
3 Hr
Laboratory 1
1.9 – 23
8  –  112
5 – 35
Laboratory  2
2.6 – 24.9
0.0  – 121.9
0.0 – 163.5
Laboratory  3
2.6 – 24.9
8  –  112
5  –  55
3  –  20
Laboratory  4
6  – 27
20  –  120
18  –  56
8  –  22
Laboratory  5
00  – 30
30  –  200
40  – 300
50  – 150
Laboratory  6
Does not include insulin ranges in the report. Instead it includes the following note: Insulin analogues may demonstrate non-linear cross-reactivity in this essay. Interpret results accordingly. Personal communications with clinicians revealed that they do not find this laboratory note to be helpful.
 
 

Spectrum of Insulin Dysfunction and Hyperinsulinism in Autism

Table 4 presents insulin and glucose profiles of 10 patients with dysautonomia. Note that all patients suffered from allergic disorders.
Table 4. Insulin and Glucose Profiles of Individuals With Autism.
The Blood Insulin and Glucose Levels Are Expressed in uIU/mL and mg/dL respectively.
Fasting
½ Hr
1 Hr
2 Hr
3 Hr
Autism Case 1. Insulin and Glucose Profiles of 14-Yr-Old 5’ 9” Boy Weighing 115 lbs.Who Presented Without Expressive Speech Since Birth.
Insulin uIU/mL
24
300
235
211
83
Glucose mg/dL
83
129
98
95
61
Autism Case 2. Insulin Profile and Glucose Profiles of 15-Yr-Old Boy With  Autism, Allergy, and Fatigue.
Insulin uIU/mL
10.4
43.7
37.6
33.7
7.8
Glucose mg/dL
79
104
86
82
53
Autism Case 3. Insulin and Glucose Profiles of 17-Yr-Old-Boy With Autism, Eczema, And Anxiety.
Insulin uIU/mL
24.4
N/A
73.8
71.6
28.0
Glucose mg/dL
95
N/A
79
79
69
Autism Case 4.  Insulin and Glucose Profiles of 8-Yr-Old Boy Presenting With Autism, Sudden Mood Shifts, and Inhalant Allergy.
Insulin uIU/mL
6.2
40.36
41.5
24.8
3.9
Glucose mg/dL
96
192
131
109
57
Autism Case 5. Insulin and Glucose Profiles of A Three-Year-Old  Boy With Asperger’s Syndrome, Temper Tantrums, Eczema, And Inhalant Allergy.
Insulin uIU/mL
1.28
14.3
0.33
Glucose mg/dL
71
126
88
Autism Case  6. Insulin and Glucose Profiles Of A Four-Year-Old Boy Weighing 35 lbs. Limited expressive speech, Often in non-communicative trance. Mother’s Words: “Very Intelligent In Things That Interest Him.”
Insulin uIU/mL
2.3
24.2
20.2
17.8
0.8
Glucose mg/dL
89
151
102
98
79
Autism Case 7 .  Insulin and Glucose Profiles of A 5-yr-old Boy With Autism Focus Disorder. No Expressive Speech Until Age 30 Months, Single Words 10-15 Words. No Voluntary Sentences. Eczema, Recurrent Ear Infections.
Insulin uIU/mL
1.31
47.16
43.99
Glucose mg/dL
64
127
150
Autism Case 8 . Insulin And Glucose Profiles  of  A 7-Yr-Old Boy Presenting With Diagnoses of Autism, Inhalant Eczema, Food Allergy, and History of Multiple Courses of Antibiotics for Sore Throats.
Insulin uIU/mL
11.0
Glucose mg/dL
73
Autism Case 9. Insulin And Glucose Profiles  of A Six-Yr-Old Boy Presented With Autism, Hypothyroidism, Food and Inhalant Allergy.
Insulin uIU/mL
13.0
Glucose mg/dL
85
The staff of a university hospital mishandled the blood samples on two different occasions.
Autism Case 10. Insulin and Glucose Profile of A 28-yr-old Man Who Was Diagnosed With Autism with complete Absence of Expressive Speech Until Age 4 And Then Transitioned to Asperger’s Syndrome. At Age 21, He Was An Excellent Athlete But Could Speak Only To His Mother.
Insulin uIU/mL
7
174
365
71.9
7.9
Glucose mg/dL
81
178
160
85
56
Follow-Up Testing One Year Later
Insulin uIU/mL
8.2
139.9
152.0
40.82
2.82
Glucose mg/dL
88
128
125
100
47

Free-Access Library for Reversing Diabetes.

First things first: Only you can reverse your diabetes, not anyone else.

What Comes First Rising Blood Sugar Level, Or Rising Blood Insulin Level?

 

Majid Ali, M.D.

No question is more important for stemming the global tides of insulin toxicity and diabetes than the question in the title.

(Part of the Diabetes Question Series)


 

The Answer:

Insulin levels rise first, usually by five, ten, or more years before blood sugars level rise.

Why is this important?

Because insulin toxicity continues to cause cellular damage in the liver, kidneys, heart, brain, eyes and other organs unknown to the patient and the doctor if insulin tests are not done.


 

Can You Reverse Diabetes?

Majid Ali, M.D.

Are You Willing and Able to Try? Is So, Continue to Read.


 

Only You Can Answer the Question in the Title.
The information given below can help you. 


Dr. Ali’s Breakfast Shakes

Majid Ali, M.D/ Dr. Ali’s Breakfast Shakes Are Ideas, Not Products   Shakes for Weight Loss and Diabetes Reversal And Related Insulin-Smart Omelettes and Other Insulin-Smart Breakfasts for Insulin-Smart eating There is n…
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The Insulin Diet

Two Insulin Diet Plans Majid Ali, M.D. Insulin is the hunger hormone. This scientific simplicity forms the core of my Insulin Diet. I  prescribe it for my patients in one of its two forms: 1.             Insulin Diet One…

Insulin-Monitored Diabetes Reversal

Majid Ali, M.D.   Yes, almond butter is an insulin-smart food. Almond butter does not cause a blood sugar spike. So it does not cause blood insulin spike.   Almond butter is a good food also because it is rich in mineral…

The LOPI Way to Reversing Diabetes

Majid Ali, M.D. The Love-Oxygen-Prayer-Insulin (LOPI) Way for Reversing Diabetes Please consider this Path Away From Diabetes for yourself and for those you love. It is not a path of products. I is the path to truth, lov…

Insulin Toxicity of the Unborn

Majid Ali, M.D. The incidence of pregnancy-associated insulin resistance is rising worldwide, I think it is appropriately designated as insulin toxicity of the unborn. The incidence of pregnancy-associated insulin resist…

Optimal and Inappropriate Laboratory Testing For Assessing Insulin Homeostasis

Majid Ali, M.D. Grievous Errors in Insulin Testing   What Is Optimal Laboratory Insulin Testing? What Are Commonly Made Grievous Insulun Testing Errors?  Optimal laboratory testing for assessing insulin homeostasis is to…

Weight Loss – Truths and Mistruths

  Majid Ali, M.D. Another Hormone for Weight Loss and for Not Looking Like a Pear The only honest way of weight loss without losing health is eating less. The scientific truths behind this statement are: Insulin is the f…

Hyperinsulinism Associated With Breast and Prostate Cancer

Majid Ali, M.D. Published in the Journal Townsend Letter (2017;409:66-69 (August 2017)   Hyperinsulinism fans the fire of cancer. In this article, I present case studies to show diet and integrative therapies can restore…

Free Access Diabetes Library

Majid Ali, M.D.


Library of Articles and Videos

Dr. Ali’s Three-Part Diabetes Course
 
Dr. Ali’s Diabetes Course – Part 1: The Basics of Diabetes
https://alidiabetes.org/2016/06/27/dr-alis-diabetes…-part-one-basics/ ‎
 
Dr. Ali’s Diabetes Course – Part 2: Insulin Detox – Beyond Sugar Talk
https://alidiabetes.org/2016/07/11/dr-alis-diabetes-course-part-two-2/ ‎
 
Dr. Ali’s Diabetes Course – Part 3:
https://alidiabetes.org/2016/07/25/dr-alis-3-part-d…ourse-part-three/
 
 
Breakfasts 2016
 
MMM
 
Lab Ref Ranges
 
 
 
Reversing Diabetes Pack
Reversing Diabetes – Lesson One
DR. ALI’S 3-PART DIABETES COURSE PART TWO
DR. ALI’S 3-PART DIABETES COURSE – PART THREE
Reversing Diabetes – Lesson Four
https://alidiabetes.org/2016/08/15/reversing-diabetes-lesson-four/
Reversing Diabetes – Lesson Five
Reversing Diabetes – Lesson Six
Reversing Diabetes – Lesson Seven Spiritual Speak
Reversing Diabetes – Seven Simple Lessons
Diabetes Recipes
DR. ALI’S 3-PART DIABETES COURSE – PART THREE
DR. ALI’S 3-PART DIABETES COURSE PART TWO
alink: https://alidiabetes.org/2016/08/15/reversing-diabetes-lesson-four/ ‎Edit Get

DIABETES VIDEO LIBRARY

Diabetes videos part 1 | The Ali Academy Community

In this 55-minute video seminar, Professor Majid Ali, M.D. discusses the causes, clinical features, and consequences of insulin toxicity, including pre-diabetes …

Diabetes Insulin Videos – Ali Healing Community

Majid Ali, M.D. Links to Videos on Prevent and Reverse Diabetes What is Diabeteshttps://www.youtube.com/watch?v=vTUFY2It-vQ What Is Insulin? What Are Its …

Majid Ali, M.D. * Insulin Toxicity De-mystifies the Metabolic Syndrome …

Jun 28, 2012 – Uploaded by majid ali

The true mature of the metabolic syndrome is insulin toxicity. The term metabolic syndrome creates creates …

Majid Ali, M.D. * Can You Increase Natural Insulin in Diabetes …

Jun 5, 2012 – Uploaded by majid ali

The answer is YES in many cases. I illustrate this with a case study. In advanced stages of diabetes Type 2 …

Majid Ali MD, Castor Oil Rubs for Insulin Detox for Weight Loss and …

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Jan 24, 2015 – Uploaded by Majid Ali

Type 2 diabetes is an insulin-toxicity state for years before the body reserves ofinsulin are depleted and the …

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I outline the contents of this book on reversing diabetes Type 2. I explain how it begins with insulin toxicity …

Insulin spikes | Ali Diabetes

Posts about Insulin spikes written by Majid Ali MD. … Reversing Prediabetes and Diabetes With 3D Plan: Insulin-Wise and Insulin-Unwise Foods and Meals. Posted on July 24, 2017 by Majid … Video for majid ali diabetes insulin videos ▷ 5:57.

Insulin-Monitored Diabetes Reversal | Ali Diabetes

Sep 30, 2017 – Majid Ali, M.D. Yes, almond butter is an insulin-smart food. … List of Videos for Learning and Implementing Dr. Ali’s Insulin-Based Diabetes …

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Dr. Ali’s Insulin Reduction Protocol

Majid Ali, M.D. … For individuals with pre-diabetes with insulin toxicity but without high blood sugar levels, my … I present this subject at length in my book entitled “Dr. Ali’s Plan for Reversing Diabetes” and in a 40-minute video seminar that can …

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Optimal and Inappropriate Laboratory Testing For Assessing Insulin Homeostasis

Majid Ali, M.D.

Grievous Errors in Insulin Testing


 

What Is Optimal Laboratory Insulin Testing?

What Are Commonly Made Grievous Insulun Testing Errors?

 Optimal laboratory testing for assessing insulin homeostasis is to use tests that directly and specifically assess various aspects of insulin homeostasis. Inappropriate laboratory testing for assessing insulin homeostasis is to use tests that do not directly and specifically assess various aspects of insulin homeostasis.
 
Examples of optimal laboratory tests for insulin homeostasis are measurement of blood insulin concentration with fasting blood samples and timed samples obtained after a standard glucose challenge. Examples of inappropriate insulin tests are fasting blood glucose level, two-hours post-prandial blood glucose level, and A1c since these tests are test for glycemic status and not for assessing insulin homeostasis. 

Grievous Errors In Insulin Laboratory Tests
 
I recognize the following commonly made grievous errors in laboratory assessment of insulin homeostasis. Regrettably, these errors are deemed optimal standards for many doctors. 
 
1.   Blood insulin tests are done on randomly drawn blood tests (Results of such tests                              simply cannot be interpreted).
2.   The epidemic prevalences of hyperinsulinism of varying degrees are near-completely                     ignored in clinical medicine and insulin tests are simply not done (Table 2). 
3.   Tests for blood  sugar levels are done as substitutes for insulin tests. Glucose tests                            and others for glycemic status simply are not insulin tests.
4.   Laboratories use wholly inappropriate references ranges for blood insulin concentrations (See Table 2 for specifics). 
5.   Cut-off points for blood insulin concentrations determined with timed, post-glucose-                   challenge are not based on real insulin testing data.
6.   Insulin is the primary pro-weight gain and pro-obesity hormone, and yet insulin tests                 are done in weight loss and obesity programs. 
7.  Gestational diabetes is an insulin disorder before it becomes a glucose (sugar)                                 disorder. Insulin tests are not done for gestational diabetes.
8.  Insulin in excess is a potent the primary pro-weight gain and pro-obesity hormone,                       and yet insulin tests are done in weight loss and obesity programs. 
9. Insulin in excess is proinflammatory, pro-infections, pro-cancer, pro-premature aging,                 and pro-degenerative disorders and yet insulin tests are seldom, if ever, done by                 most doctors. 
10. Indeed, insulin in excess increases the risk of and fans the fires of all nearly chronic                  diseases 

Two Subtypes of Type 2 Diabetes: T2D Subtype A and T2D Subtype B
In 2014, I recognized the need to subtype Type 2 diabetes (T2D) into two T2D subtypes:
                              T2D subtype A
                               T2D subtype B
Diabetes is a two-faced disease, one with insulin toxicity and the other with insulin depletion: this diabetes duality in itself is most revealing. Below we present five sets of illustrative insulin and glucose profile taken from our original communication to make and illustrate our main points, which are presented and its full clinical implications considered in a separate chapter For the first five, ten or more years, the disease is characterized by rising blood sugar levels accompanied by increasing blood concentrations of insulin (hyperinsulinism aptly designated insulin toxicity). In the later years, T2D is characterized by rising blood sugar levels accompanied by falling insulin levels, this is the stage of insulin depletion (see Tables 1.1 and 1.2 for details).
Table 1. Insulin Homeostasis Categories in 506 Study Subjects Without Type 2 Diabetes
Insulin Category*
Percentage of Subgroup
Mean Peak Glucose  mg/dL
(mmol/mL)
Mean Peak Insulin (uIU/mL)
Exceptional Insulin Homeostasis.N 12**
1.7%
110.2     (6.12)
14.3
Optimal Insulin Homeostasis N =126
24.9 %
121.2     (6.73)
26.7
Hyperinsulinism, Mild                N =197
38.9 %
136.5   (7.58)
58.5
Hyperinsulinism,  Moderate       N =134
26.5 %
147.0    (8.16)
109.1
Hyperinsulinism,  Severe             N =  49
9.7 %
150.0    (8.33)
(less than time and a half higher) 
231.0
(nearly 17 times higher)
#   Correlation coefficient, r value, for means of peak glucose and insulin levels in the five insulin categories is 0.84.
*Criteria for classification: (1) Exceptional insulin homeostasis, a subgroup of optimal insulin homeostasis with fasting insulin concentration of <2 uIU/mL and mean peak insulin concentration of <20; (2) optimal insulin homeostasis, peak insulin <40 accompanied by unimpaired glucose tolerance; (3) mild
 


Table 2.  Insulin Reference Ranges  in uIU/mL of Six Laboratories in New York Metropolitan Area*
 Laboratory
 Fasting
 1 Hr
 2 Hr
 3 Hr
 Laboratory 1
1.9 – 23
8  –  112
 5 – 35
 Not Reported
 Laboratory 2
 2.6 – 24.9
 0.0  – 121.9
 0.0 – 163.5
 Not Reported
 Laboratory 3 
 2.6 – 24.9
 8  –  112
 5  –  55
 3  –  20
 Laboratory 4
 6  – 27
 20  –  120
 18  –  56
 8  –  22
 Laboratory  5
 00  – 30
 30  –  200
 40  – 300
 50  – 150
 Laboratory 6
 Does not include insulin ranges in the report. Instead it includes the following note: Insulin analogues may demonstrate non-linear cross-reactivity in this essay. Interpret results accordingly.**
*Upper and lower limits of laboratory reference ranges for blood insulin concentration determined following a Standard 75-gram glucose challenge.
**Personal communications with clinicians revealed that they do not find this laboratory note to be satisfactory in their clinical decision-making.

Grievous Errors in Insulin Testing

First Grievous Error: Believing That Diabetes (T2D) Is a Sugar (Glucose) Problem 
The first grievous error of considering insulin insufficiency as the cause of T2D has misled generations of doctors, leading to the mistreatment of hundreds of millions of people with prediabetes and T2D. In reality, hyperinsulinism predates T2D for five to ten or more years, although the study of insulin homeostasis is not deemed a standard of care for health preservation and disease prevention and/or control. Indeed, it is not taught in medical schools or on hospital wards, even where there are patients with suspected or diagnosed diabetes. The neglect of this core aspect of insulin dysregulation results in: (1) delayed diagnosis of T2D, and (2) as we document conclusively, the failure to detect and address long-established metabolic, inflammatory, immune, cardiovascular, and neurological consequences of insulin hyperinsulinism (Bahi-Buisson et al., 2008; Dandona, Aljada and Bandyopadhyay, 2004; IDFDA, 2016; Khan, Hull and Utzschneider, 2006; Shoelson, Lee and Goldfine, 2006; Shulman, 2014; Wellen and Hotamisligil, Shargill and Spiegelman,2005). Notable in this context is the recent documentation of hyperinsulinism in autism and pediatric dysautonomia (Ali, 2017a), which is discussed in chapter 6.
During the years of excess insulin – hyperinsulinism, or more appropriately insulin toxicity – widespread damage is inflicted in nearly all cell populations in the body. There is a profound irony here.  The very definitions of T1D and T2D lays bare the falsehood of the prevailing belief, the former being a state of near-complete absence of insulin in the blood while the latter for years is accompanied by raised blood insulin concentrations (as documented in Table 1.2). To add to the irony of this, consider the definition of insulin from the website of Merriam Webster Dictionary (March 15, 2017) reproduced verbatim here:
a protein pancreatic hormone secreted by the beta cells of the islets of Langerhans that is essential especially for the metabolism of carbohydrates and the regulation of glucose levels in the blood and that when insufficiently  produced results in diabetes mellitus …and that when insufficiently  produced [insulin] results in diabetes mellitus!
Consequently, it is not surprising that this utterly false notion of T2D caused by insulin insufficiency has become so deeply entrenched in public consciousness? The enduring belief of medical and nursing communities in this misleading dogma is of great concern. The key question is why has this definition not been previously challenged by the medical community?
To bring this grievous error into yet sharper focus, T1D is an acute-onset type disease usually occurring in children, characterized by near-complete absence of insulin-producing capacity of the pancreas gland. By contrast, T2D develops insidiously and, until recently, nearly always developed in adults. The blood insulin concentrations begin to fall after decades of insulin waste that occurs during the hyperinsulinism phase of the disease: this is what medical students learn in classrooms and on medical wards and  what nurses learn in nursing schools. Then the medical tragedy happens. Simple blood tests, for determining blood insulin concentrations to assess the state of insulin homeostasis of individual patients, is not considered a standard of care in any medical specialty or general practice. This disturbing notion of T2D being rooted in insulin insufficiency persists and so the hazards of insulin toxicity go unrecognized.

Second Grievous Error
Neglect of a Specific Quantitative and Modifier Marker
 The Third Grievous Error: Absurd Laboratory Insulin References Ranges
The third grievous error concerns laboratory reference ranges for blood insulin concentrations reported by most university hospital and nationwide commercial laboratories. Rather than guide clinicians interested in the study of insulin dysregulation in their patients, clinical pathologists and laboratory professionals have for decades compounded the problem of neglected hyperinsulinism. Table 1.3 displays wide variations in the lower and upper limits in the reference ranges for fasting and post-glucose challenge blood insulin concentrations employed by six major laboratories in the New York City metropolitan area. The variation in insulin reference ranges invariable invites skepticism, with photographs of actual laboratory reports on the web (www.alidiabetes.org). Note that laboratory 1 reports a range of 5-35 for 2-hour blood insulin level while laboratory 5 reports of range of 40-300 for the sample blood sample: while laboratory 1 reports a range of 5-35 for 2-hour blood insulin level. Further, laboratory 5 reports of range of 40-300 for the sample blood sample, while laboratory 2 reports a range of 0.0 to 121.9 and laboratory 4 reports 20-120 for the same blood sample. It is difficult to imagine a parallel for this level of absurdity in the entire field of laboratory medicine.

Cut-off Points for Optimal Insulin Homeostasis and Degrees of Hyperinsulinism
Our selection of the peak insulin value of <40 mIU/mL as the cut-off point for optimal insulin homeostasis in our survey of prevalence of hyperinsulinism in New York (see Table 1.1), was based on a preliminary review of the first 50 sets of insulin and glucose profiles (Ali et al., 2017a). We opted for cut-off points for hyperinsulinism stratification based on doubling of the levels (to <80, <160, and >160 uIU/mL for mild, moderate, and severe hyperinsulinism) with two considerations: (1) are these cut-off points appropriate for this study, and (2) do they provide a frame of reference for future investigations of diverse aspects of insulin homeostasis and hyperinsulinism-to-T2D progression? There are a number of other issues that need to be considered in this context: (1) what constitutes optimal insulin homeostasis, (2) what should the insulin cut-off point be, as there is no agreement within the relevant literature, (3) no adverse effects of low insulin levels when accompanied by unimpaired glucose tolerance have been reported, and (4) Hyperinsulinism and the metabolic syndrome are commonly spoken in the same breath,  explicitly or implicitly referring to them as the two faces of the same coin. However, there is a crucial difference between the two, the peak insulin level and other features of three-hour insulin and glucose profiles provide clinicians with  specific and quantitative cut-off  points for detecting and stratifying hyperinsulinism but no such criteria have been established for the metabolic syndrome. In addition, three-hour insulin and glucose profiles shed light on other aspects of glycemic status and insulin homeostasis, some of which are presented later in this chapter.
A subgroup of twelve participants was designated ‘exceptional insulin homeostasis’ for two reasons: (1) they showed an extremely low fasting insulin value of <2 uIU/mL (mean 14.3 uIU/mL) and peak insulin concentrations <20 uIU/mL accompanied by unimpaired glucose tolerance, and (2) ten of the twelve had no family history of diabetes (parents, siblings, grandparents, children, uncles or aunts), while the mother of the eleventh subject developed T2D in the closing months of her life at age 74 and both parents of the twelfth subject had T2D. This subgroup appears to reflect ideal metabolic efficiency of insulin in the larger evolutionary context.

Shifting Focus from Glucose Testing to Insulin Testing
As reported in the preface, the much higher rate of hyperinsulinism observed in New York’s general population compared to rates of T2D in India (Kaveeshwar and Cornwell, 2014) and China (Xu et al., 2013), provides strong support for the view that there is a need to shift focus from glucose testing to insulin testing for stemming global tides of hyperinsulinism and T2D. A crucial point in this context is that the data published in the Indian and Chinese studies was derived from glucose testing, whereas our insulin database was derived exclusively from direct insulin testing, with measurements of post-glucose challenge blood insulin concentrations with sequential and timed blood samples.
Here we point out that the insulin and glucose profiles presented in this and other chapters shed light on the full spectra of insulin homeostasis, hyperinsulinism and related patterns of insulin dysfunction, for example insulin spikes followed by hypoglycemic episodes which create hunger for foods that create yet more sugar spike. Therefore the insulin and glucose profiles presented in Tables 1.4-1.8 in this (and numerous in other chapters) require that the data be considered in light of the clinical context as well as looking through the kaleidoscopic prisms of molecular biology of oxygen Ali, 2000, 2002, 2004a, 005a, 2007, 2009a, 2011), oxygen model of hyperinsulinism (Ali, 2014a) and oxygen model of T2D (Ali, 2001). As for co-morbidities of the hyperinsulinism-T2D continuum (metabolic, inflammatory, immune, infectious, cardiovascular, neurological, developmental, gut-microbiota-related, differentiative, and degenerative), we do not recognize any  inconsistencies between our observations and inferences and those of earlier workers (Nath, Heemels and Anson, 2006; Nichols, 2012; Patti et al., 2003; Saltiel and Kahn, 2001; Scherer, 2005; Stanley, 2016; Turnbaugh, 20

 


Table 3. Insulin Homeostasis Categories in 178 Study Subjects With Type 2 Diabetes
Insulin Category
Percentage of Subgroup
Mean Peak Glucose, mg/dL
(mmol/mL)
Mean Peak Insulin (uIU/mL)
Diabetic Hyperinsulinism, Mild              N =  53
29.0%
252.0   (14.00)
55.4
Diabetic Hyperinsulinism, Moderate    N =  42
24.0%
242.1   (13.45)
112.4
Diabetic Hyperinsulinism, Severe          N =  24
13.9%
224.6   (12.47)
298.0
Diabetic  Insulin Deficit                             N =  59
33.1%
294.0    (16.33)
22.9
Illustrative Case Studies of Insulin Responses to Glucose Challenge
Tables 4 to 8 present five illustrative sets of insulin and glucose profiles with brief clinical notes. The insulin profiles in Tables 4 and 8  represent the two extremes of insulin peaks (18 uIU/mL and 718.2 uIU/mL) encountered in this survey. The first of the two profiles (Table 4) is reflective of ideal metabolic efficiency of insulin in a larger evolutionary perspective of energy economy in the body. Notable findings here are: (1) a very low fasting insulin level of <2 uIU/mL reflecting efficient insulin conservation during the fasting state; (2) low insulin peak value (18 uIU/mL) indicating high insulin efficiency following a substantial glucose challenge; and (3) a very low insulin level in the 3-hour sample (<2 uIU/mL) reflects optimal beta cell response to glucose level falling below the fasting level.
 
Table 4. Example of Insulin and Glucose Profiles In Exceptional Insulin Homeostasis Category*
 
Fasting
½ Hr
1 Hr
2 Hr
3 Hr
Insulin uIU/mL
<2
18
14
4
<2
Glucose mg/mL  (mmol/L)
77     (4.27)
168   (9.33)
109      (6.05)
74       (4.11)
59    (2.88)
*The Patient,  A  60-Yr-Old 5’ 7” Man Weighing 138 lbs. Presented for a Wellness Assessment. He Was Considered to be in Excellent Health By Clinical and Laboratory Evaluation Criteria.
Table 5.  Severe Hyperinsulinemia in A Subject With Previously Undiagnosed Type 2 Diabetes*
 
Fasting
½ Hr
1 Hr
2 Hr
3 Hr
Insulin uIU/mL
23.8
19.3
36.9
114.7
75.2
Glucose mg/mL  (mmol/L)
112     (6.21)
158   (8.77)
214      (11.76)
241    (13.38)
129   (7.16)
* The Patient,  A 64-Yr-Old 5’ 4” Woman Weighing 164 lbs. Presented With Hypothyroidism, History of Coronary Artery Stent Insertions, Fatty Liver, Memory Concerns And Without Previous Diagnosis of Type 2 Diabetes.
Table 6. Hyperinsulinism 18 Years After the Diagnosis of Type 2 Diabetes*
Fasting
½ Hr
1Hr
2Hr
3Hr
Insulin uIU/mL
  12.9
27.2
29.2
36.2
25.4
Glucose mg/mL  (mmol/L)
128      (7.10)
224   (12.43)
278    (15.42)
297    (16.48)
249     (13.81)
*The Patient,  A 74-Yr-Old 5’ 6” Woman Weighing 155 Lbs. Presented With Bronchiectasis, Rheumatoid Arthritis, Prehypertension, and Inhalant Allergy.
Table 7. Brisk Insulin Response With A “Flat” Glucose Tolerance Profile*
Fasting
½ Hr
1Hr
2Hr
3Hr
Insulin uIU/mL
3
23
22
8
<2
Glucose mg/mL  (mmol/L)
72      (3.39)
44     (2.44)
63    (3.49)
58     (3.21)
65   (3.90)
*The Patient,  A 47-Yr.Old  5’ 5” Woman Weighing 170 Lbs. Presented With Polyarthralgia, Recurrent Sinusitis, and Fatigue.
Table 8. Severe Hyperinsulinism In A 13-Yr-Old Girl With Lupus Erythematosus*
Fasting
½  Hr
1Hr
2Hr
3Hr
Insulin uIU/mL
27.9
362.5
424.0
718.2
571.7
Glucose mg/mL  (mmol/L)
      70   (3.88)
  140     (7.77)
   157     (8.71)
   150    (8.33)
   111   (6.16)
Insulin and Glucose Profiles Obtained After Four Months of Robust Integrative Therapies
Insulin uIU/mL
7.2
125.1
238.5
208.0
132.0
Glucose mg/mL  (mmol/L)
81     (4.49)
154   (8.54)
181     (10.04)
130     (7.21)
97      (5.38)
*The Patient,  A 13-Yr-Old Girl With a History of Three Hospitalizations In One Year for Systemic Lupus Erythematosus, Recurrent Pneumonia, Thrombocytopenia, and Severe Optic Neuritis Resulting In Complete Loss of Vision In Right Eye. The Peak Insulin Fell from 718 to 238.5 In Four Months of Robust Integrative Treatment.
 

Hyperinsulinism Associated With Breast and Prostate Cancer

Majid Ali, M.D.

Published in the Journal Townsend Letter (2017;409:66-69

(August 2017)


 

Hyperinsulinism fans the fire of cancer. In this article, I present case studies to show diet and integrative therapies can restore insulin homeostasis and, thereby:

  1. Reduce the risk of prostate and breast cancer growth.
  2. Improve results in the treatments of these cancer.
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