Category Archives: Dr. Ali’s Course on Insulin Toxicity

Insulin Toxicity – Early Signs

Majid Ali, M.D.

Early Signs of Insulin Toxicity Are Diabetes Complications Not Diagnosed for Years Before They Actually Diagnosed.  


What Google Told Me About Complications of Diabetes

·       Cardiovascular disease. …
·       Nerve damage (neuropathy). …
·       Kidney damage (nephropathy). …
·       Eye damage (retinopathy). …
·       Foot damage. …
·       Skin conditions. …
·       Hearing impairment. …
·       Alzheimer’s disease

What My PatientsTaught me About Insulin Toxicity

Blood insulin test should be done for the following conditions since there is high probability that the underlying fires of these conditions are fed by insulin toxicity.
·       Loss of Vigor
·       Weight gain
·       Course skin
·       Acne in teenager
        Skin pigmentation changes
·       Facial hour for young women
·       Tingling and numbness in toes and fingers
·       Brain fog
·       Cognitive difficulties
·       Memory loss
·       Any infections that do not heal
·       Any inflammation that does not heal
·       Colitis of immune-inflammatory disorders
·       Arthritis of immune-inflammatory disorders
·       Connective tissue diseases
·       Any skin conditions that do not heal
·       Neurodermatitis
·       Brain atrophy
·       Brain degenerative conditions
·       Rising blood creatinine level
·       Rising liver enzyme levels
·       Rising CRP test results
·       Liver ultrasound with fatty liver disease, steatosis, or steatonecrosis.


DR. Ali’s Library of Diabetes



Dr. Ali’s Insulin Library

Majid Ali, M.D.

My Oxygen Thinking Has Given Me Insights About the Roles of Insulin in Health and Disease which Robustly Challenge the Prevailing Notions of Insulin, Insulin Resistance, and Hyperinsulinism. 


Large Claims Require Large Bodies of Information

I offer my free-access library of insulin and hyperinsulinism (links included below) in an attempt to meet my obligation when I choose to challenge the prevailing dogmas of hyperinsulinism and Type 2 diabetes (T2D).

I would be most grateful to visitors to this website who find errors in my materials or disagree with me in other ways to send their disagreements to me at  

Dr. Ali’s Insulin Library

Community Texts : Free Books : Free Texts : Download & Streaming …

Majid Ali, M.D. Why I Don’t Recommend Skim Milk Products. – -. by Majid Ali, M.D.. texts … 20 20. 4. IJGMP Metabolic Syndrome. Aug 20, 2016 08/16. by IASET …

Seven Stages of Insulin Toxicity | The Ali Academy Community

Apr 30, 2011 – Majid Ali, M.D. In matters of life span, I summarize the lessons learned from my patients with the following simple words: Keep insulin low …

Insulin Toxicity and Dysfunction videos part 1 | The Ali Academy …

Insulin Literacy Understanding Insulin Dysfunction A1c and Insulin Toxicity from Majid Ali on Vimeo. Cheese Is Good For Reversing Insulin Toxicity Part Two …

The Oxygen Model of Insulin Toxicity – Majid Ali, M.D. | The Ali …

Aug 4, 2012 – I proposed my Oxygen Model of Insulin Toxicity as a unifying model that recognizes disturbances of oxygen functions as the fundamental …


Insulin Toxicity. Majid Ali, M.D.. Related … Insulin Thinking Videos on YouTube Encyclopedia … Hypoglycemia) Is Nearly Always Caused by Insulin Toxicity.

Seven Stages of Insulin Toxicity – Dr. Ali’s Virtual Medical Library

Seven Stages of Insulin Toxicity. Majid Ali, M.D. In matters of the life span, I summarize the lessons learned from my patients with the following simple word.

Insulin Toxicity – Dr. Ali’s Virtual Medical Library

Dr. Ali’s nsulin Toxicity Course Majid Ali, M.D.. I divide my Insulin Toxicity Course in the following two parts: Insulin Toxicity Course Part One. Insulin Toxicity …

Majid Ali, M.D. * Insulin Toxicity De-mystifies the Metabolic Syndrome …

Jun 28, 2012 – Uploaded by majid ali

The true mature of the metabolic syndrome is insulin toxicity. The term metabolic syndrome creates creates …

Seven Stages of Insulin Toxicity Seminar Majid Ali MD on Vimeo › Majid Ali › Videos
May 12, 2014

Professor Majid Ali shares information about “Seven Stages of Insulin ToxicitySeminar”

Insulin Toxicity De-mystifies the Metabolic Syndrome Majid Ali MD on … › Majid Ali › Videos
Apr 6, 2014

Professor Majid Ali MD. shares information about Insulin Toxicity De-mystifies the Metabolic Syndrome.

Dr. Ali’s Course on Insulin Toxicity | – Ali Healing Community

Jan 11, 2017 – Majid Ali, M.D. Workable Simplicity to Understand Maddening Complexity of Three Scourges of Our Time Dr. Ali’s Insulin-Diabetes Video and …

Ali Diabetes | Preventing and Reversing Diabetes With Insulin Literacy

5 days ago – Preventing and Reversing Diabetes With Insulin Literacy. … Majid Ali, M.D. ….. Majid Ali, M.D. * Insulin Toxicity De-mystifies the Metabolic …

Insulin Toxicity | Ali Academy

Feb 9, 2015 – Posts about Insulin Toxicity written by Majid Ali MD.

Dr. Ali’s Autism Course | Childrens Health Corps

Sep 20, 2015 – Majid Ali, M.D. Evidence for My Proposed Insulin-Autism Connection … studies of the energetic-molecular of autism, as well as insulin toxicity.

Dr. Ali Course On Insulin Toxicity — Blogs, Pictures, and more on …

Diabetes Is Rooted In Insulin Toxicity – Part Two. Majid Ali, M.D.. Diabetes Begins 15–20 years before it is diagnosed. Text Reproduced From An Important …

Insulin Neuropathy Reversed With Natural Remedies Majid Ali, MD

Majid Ali, M.D.. In my clinical experience, the most common cause of neuropathy is insulin toxicity. Some years ago, I introduced the term “insulin neuropathy” for …

Majid Ali

Sign up for Dr. Ali’s E-Newsletter. Dr. Ali’s … Majid Ali, M.D.’s Seminars … $14.95, Reduction of Insulin,Toxicity of Insulin, and the Management of Insulin. $14.95.

DIABETES – Insulin Toxicity and Reversal of Diabetes Seminar by … › Movies and Videos › Educational

In this 55-minute video seminar, Professor Majid Ali, M.D. discusses the causes, clinical features, and consequences of insulin toxicity, including pre-diabetes …

Majid Ali MD, Gestational Diabetes Is Insulin Toxicity of the Unborn …

Jan 22, 2017 – It is regrettable that doctor order glucose tolerance for expecting mothers but do not include insulin tests with the same blood tests. Excess …

Dr. Majid Ali, MD discusses the serious impact of insulin toxicity … Dr. Cal Streeter talks about the dangers of a couple of traditional cancer treatments. He also talks about the body’s own ability to kill …

Restoring Insulin Homeostasis, Reversing Diabetes

Majid Ali, M.D.

The Work of True Physicians Does Not Belong to Them, just As Their Words Do Not Belong to Them.  

The Healing of True Physician’s Belongs to Their Patients, ,Just As the Words of True Writers Belong to Their Readers.

First Things First

I.  There are two true markers of real enduring health:

                                                         1. Oxygen health

                                                         2.  Insulin health

II. To understand health is to understand oxygen health and insulin health.  

III. To understand disease is to understand inflammation.

IV. No healing is possible without physiological healing.

V. No disease is possible without pathologic inflammation.

VI. Pathologic inflammation results from disrupted oxygen and insulin signaling.

Insulin Health

Dr. Ali’s Diabetes Library 

Dr. Ali’s Diabetes Course – Part 1: The Basics of Diabetes…-part-one-basics/ ‎
Dr. Ali’s Diabetes Course – Part 2: Insulin Detox – Beyond Sugar Talk ‎
Dr. Ali’s Diabetes Course – Part 3:…ourse-part-three/ 
Diabetes Recipes
 Reversing Diabetes – Lesson One
 Reversing Diabetes – Lesson Two
 Reversing Diabetes – Lesson Three
Reversing Diabetes – Lesson Four
Reversing Diabetes – Lesson Five
Reversing Diabetes – Lesson Six
 Diabetes Recipes

Dr. Ali’s Insulin Library

Spiritual Healing Course byMajid Ali, M.D.
 What Is Insulin? What Are Its Functions?
 Insulin Detox for Wight Loss and Diabetes Reversal
 I’m Hungery After Meals. Why?
 Insulin Buddy and Fatty Liver
 What is the Evidence That Neuropathy Is Caused by Insulin Toxicity?
Obesity Is Cellular Inflammation
Dr. Ali’s Best Anti-Insulin Toxicity Breakfast
 Gestational Diabetes Is Insulin Toxicity of the Unborn – Part Two
Your Child – Hyperactive or Hypoglycemic?
Why Do I Consider Blood Insulin Test to be the Most Important Test for Metabolism and Diabetes 
Insulin-Toxic Obesity
What Is the Most Important Question in Science, Health, and Healing
What Is the Second Most Important Question in Science, Health, and Healing
Insulin Videos
What is Diabetes
Insulin Toxicity De-mystifies Syndrome X
Don’t Trust A1c for Diabetes Diagnosis, Please!
 Recipes for Insulin Toxicity – Majid Ali, MD
Almond Butter Snack for Losing Weight and Reversing Diabetes, An Excellent Choice
Peanut Butter or Hemp Seed Butter Peanut Butter Snack for Weight Loss and Diabetes Reversal
 Dr. Ali’s Insulin Course, Basics
What Is the Problem With Calorie Counting?
Is a Calorie a Calorie a Calorie?
Is Insulin Excess Bad for the Heart?
What Is Diabetes? Majid Ali, M.D. With Ben Svoboda
Is Excess Insulin Toxic to Nerves
Majid Ali, M.D. – Is a Calorie a Calorie a Calorie?
I’m Hungry After Meals. Why?
Recipes for Insulin Toxicity – Majid Ali, MD
Almond Butter Snack for Losing Weight and Reversing Diabetes, An Excellent Choice
Peanut Butter or Hemp Seed Butter Peanut Butter Snack for Weight Loss and Diabetes Reversal
 Diabetes and insulin Majid Ali MD
Why Do I Consider Blood Insulin Test to be the Single Most Important Test
What Is Your Child’s Peak Insulin Level? Is She or He Insulin-Toxic?

Insulin-Based Diabetes Prevention and Reversal Plans – Seven Simple Lessons


 Majid Ali, M.D.

Can You Reverse Your Diabetes? Only You Can Answer the Question.


Seven Simple Lessons

  1. Diabetes is not a sugar problem. If you think it is, you can never prevent or reverse diabetes.
  2. Diabetes is an insulin toxicity problem.
  3. Insulin hormone in excess is highly toxic. The body produces excess insulin hormone to keep blood sugar in the healthy range because greased-up cells cannot respond to insulin, which in health drives glucose (sugar) into cells.
  4. I coined the terms “insulin toxicity” and “insulin-literacy” over twenty years ago for patient education and established (now also to promote insulin awareness.
  5. You know the simple “insulin-toxicity–to–diabetes” scientific truth the easy way, and prevent and/or reverse diabetes (type 2). Or remain insulin-illterate, become insulin-toxic, then prediabetic, get diabetes, and then sooner or later develop all diabetes complications.
  6. All drugs for diabetes type 2, no matter how essential for the short-term, work by increasing insulin), increase degrees of insulin-toxicity, and prevent diabetes reversal.
  7. Be insulin-literate, eat insulin-smart, live insulin-wise, and be your own healer.


 Dr. Ali’s Insulin Library

My FREE Insulin Library includes the following:

  1. Over 150 articles on insulin physiology, pathology, and toxicity
  2. Over 75 videos
  3. Five 30 to 45-minute video seminars at Vimeo, YouTube, and other platforms.
  4. Ali’s Free Obesity and Weight Loss Courses
  5. Ali’s Diabetes Course
  6. Ali’s Oxygen Course
  7. Ali’s Fermentation Course
  8. Book: Dr. Ali’s Diabetes Reversal Plan
  9. Book: Oxygen and Aging


My books and DVDs are available by phone (1-212-873-2444) and at

Fruit Juices Are Fertlizers for Gut Fermentors

Majid Ali, M.D.

I would have never told my maternal grandmother that she should not drink fruit juices or eat fruits freely. Nor would have I ever told my paternal grandmother not to drink fruit juices or eat fruits freely. Why? Because they both lived to be 101 – without high blood pressure, diabetes, heart disease, or stroke.

I have no hesitation to tell mothers not to give fruit juices to their children freely? Because they live in age of gut fermentation and fruit juice is a fertilizer for gut fermenters. Nearly all children in the U.S. now have excess fermentation in their alimentary tracts. Fruit juices are pouring fuel on fermentation fires. If you have this surprising or even worthy of ridicule, please consider “Dr. Ali’s Fermentation Course” linked below. It is free.

Why I Don’t Use Random Insulin Test,

Majid Ali, M.D.

The shirt answer: Because it is not reliable.

Blood insulin level test done with a randomly drawn blood sample should not be done. It is unreliable at many levels. I refuse to interpret such an insulin test whenever I am asked to do so. Indeed, I do not know of any valid reason why any doctor should order this test. Sadly, I continue to see random insulin test reports.

The shirt.

My Reasons for Not Ordering Nor Interpreting Random Insulin Test

A random insulin level of a healthy individual after a large glass of orange juice and cereal breakfast is likely to be more than ten units, which is more than five times the fasting insulin value in many metabolically fit persons.

A random insulin level of a person with diabetes after an egg, fish, and coffee without sugar is likely to be considered normal.

The random insulin levels of persons with prediabetes vary over such a large range that no valid interpretation is possible.

The random insulin levels of persons with diabetes depend on the stage of the disease, very high in early insulin-excess stages and very low in late insulin-depleted stages.

For the above and other reasons, random insulin test must neber be used for screening for diabetes, nor for assessing the results of diabetes control.

Insulin Profile for Optimal Metabolic Status

An insulin profile indicates optimal metabolic status (Table 1) when:

* The fasting insulin value is three or less, ideally less than two;

* The three-hour insulin value is three or less, ideally less than two;

* The peak insulin level is 25 or less;

* The blood peak glucose level is below 120

* The lowest blood sugar level is above 50 and unaccompanied by any negative senses.

Case Study

A 75- yr-old 5′ 7″ man weighing 142 lbs. presenting with a history of undue tiredness, gastritis and GERD (gastroesophageal reflux disorder), inhalant allergy, visual loss, and a history of prostate cancer. His doctor never suspected the presence of diabetes and had not considered ordering insulin and glucose profiles. His glucose and insulin profiles were abnormal (Table 1). Diabetes Type 2 was diagnosed (to his surprise) by his glucose profile and insulin toxicity (hyperinsulinemia) by insulin profile.

Table 1. Insulin and Glucose Profiles of a 75- yr-old 5′ 7″ Man Weighing 142lbs. And Presenting With GERD/gastritis, Allergy, and Visual Loss.



1/2 Hr

1 Hr

2 Hr











Note that both insulin and glucose profiles fail all of the above-listed criteria for insulin and glucose profiles for optimal metabolic. The insulin peak is usually seen in one-half or one-hour samples. An unusual aspect of this insulin profile is that the insulin peak is seen in the two-hour sample. A three-hour insulin value could have been even higher.

Two Examples of Insulin Profile for Optimal Metabolic Status

It is important to learn about what a healthful insulin profile should be. For this purpose, Tables 2 and 3 present the insulin profiles two of my patients which reflects the optimal metabolic status.

Table 2. Insulin and Glucose Profiles of a Metabolically Fit 47- Yr-Old 5′ 5 1/2″ Woman Weighing 170 lbs. With Fatigue, Allergy, Sinusitis, and Joint Stiffness

3.7. 2010


1 Hr

2 Hr

3 Hr

4 Hr













Table 3. Insulin and Glucose Profiles of a 40-yr-old 140 lb. 5′ 6″ Woman Presented With Allergy.



1 Hr

2 Hr

3 Hr

4 Hr













Table 4. Insulin and Glucose Profiles of a Metabolically- Compromised 68-Yr-Old 5’4″ Woman Weighing 134 lbs. With Overactive Thyroid (Hyperthyroidism), Headache, Low Blood Sugar (Hypoglycemia, Stress. and a very Low Vitamin D Level of Less Than Seven.

6.2. 2010


1 Hr

2 Hr

3 Hr

4 Hr












Table 5. Insulin and Glucose Profiles of a Metabolically- Compromised 55-Yr-Old Man Weighing 149 lbs. With Kidney Failure, Hypertension, Chronic Fatigue, and Prostate Enlargement.

5.17. 2010


1 Hr

2 Hr

3 Hr

4 Hr













Table 6. Insulin and Glucose Profiles of a Severely Metabolically Unfit of a 5′ 5″Man Weighing 214 lbs. With Fatty Change of the Liver, Irritable Bowel Syndrome, and Chronic fatigue.



1 Hr

2 Hr

3 Hr

4 Hr













Articles in Insulin Course

The Age of Metformin Mania


Majid Ali, M.D.

Metformin is my drug of choice when I have to prescribe it for treating diabetes type 2 when I initiate my diabetes reversal plan. The only serious adverse effect of metformin occurs only in patients with vitamin B complex deficiency. I avoid it for my patients with PCOS (polycystic ovary syndrome syndrome) which is insulin toxicity leading to testosterone toxicity and later to cyst formation in the ovaries.

Now comes the age of “metformin mania” in which the drug is being heavily promoted with irresponsible claims.

Recently, Life Extension— a magazine I have greatly admired for years—unleashed what might be properly called “metformin mania.” Consider the title of the article in its November 2010 issue : “The drug virtually everyone should ask their doctor about.” Here is a revealing quote from the same article: “…that aging humans can derive benefit from an antidiabetic drug called metformin.” I point out that the magazine did not promote the use of this antidiabetic drug for diabetics but for people without diabetes.

Type 2 diabetes is caused by insulin receptor dysfunction resulting from toxicities of foods, environment, and thoughts. Excess insulin (hyperinsulinemia) so produced is inflaming, fattening, and cellular grease-building. For most individuals who are unwilling to take responsibility for their health, address these issues, control insulin toxicity, and possibly de-diabetize themselves, metformin indeed is a good drug. However, this is a far cry from advising people without diabetes to take the drug for improving health. This is as illogical as prescribing metformin for the so-called polycystic ovary syndrome, another form of insulin toxicity caused by the trio toxicities of foods, environment, and thoughts, in which insulin toxicity plays a crucial role.

Metformin and Inflammatory Markers

Life Extension told its readers that metformin is good for people without diabetes because it positively affects some genetic pathways. Specifically, it inhibits some inflammatory pathways, including AMPK and stabilizes the age-accelerating complex called mTOR. It failed to mention that these pathways are also activated by toxicities of foods, environment, and thoughts. So, metformin does not correct the underlying problems, just controls their consequences. There is no evidence that it does so long-term.

The article also cited studies in which the drug extended the life span of mice. Extension of life spans of animal species with drug, of course, is old news. In animal experiments, the extension of life span is always associated with birth defects, tissue development disorders, and metabolic derangements. Serious students of human biology do not allow such studies to be used as justification of using drugs. Certainly, to date, there is no evidence that humans ever live longer with drugs tested in animals.

Metformin and Cancer Risk

Life Extension underscored the point that metformin suppresses a cancer inducing protein called human epidermal growth factor receptor-2 (HER-2) and asserted that the drug “can stop cancers from developing.” Next it cited a study that showed that “metformin use by humans is associated with a substantial (56%) reduction in the risk for developing breast cancer.” In the past, Life Extension has also claimed that risk of breast cancer can be reduced by spices, foods, and nutrients. For example, Life Extension in its September 2005 issue explained its vision of a simple business plan for immortality in which a grand spare parts relacement industry will allow people to live happily forever. Consider the following quote: ‘It is only a matter of years — decades at most — until futuristic technologies will entirely reverse-engineer the human machine.’

Such claims, in reality, are half truths and untruths. Medical literature is replete with reports of cancer risk reduction of foods, spices, and drugs. Taken at their face values, all cancers could be eradicated from the face of the earth by just taking three or more such substances. Alas, that will not happen. The risk reduction games are mere number games. Again serious students of human biology learn early in their lives about the frivolousness of such claims. Incremental toxicities of foods, environment, and thoughts will continue to fan the epidemics of cancer.

Metformin for Treating Cancer

Should Metformin be used to treat forms of cancer that cannot be treated with surgery or radiotherapy? It is possible its anti-inflammatory effects may prove to be beneficial in certain cases. So, it would be prudent to explore this possibility when the other therapies fail to control the tumor. I do hope that the Metformin mania will not lead to the replacement of effective therapies for cancer—when complete surgical excision of the growth can be reasonably expected, for instance—to the great detriment of the patient. Regrettably I have seen that in many cases.

Metformin for Thyroid Disorders and Hepatitis C

Among the interesting references to Metformin in the literature are suggestions for its use for treating hypothyroidism and Hashimoto thyroiditis. The drug in some cases is reported to have lowered TSH levels, possibly without affecting thyroid hormone levels. Since I find TSH level to be the more reliable test in monitoring the effectiveness of thyroid replacement in these entities, it is not clear how that would prove to be useful.

It has also been suggested that the use of Metformin and AICAR, another anti-diabetes drug be considered in the treatment of hepatitis C. Since fatthy change of the ,iver frequently coexists with hepatitis C, this may indeed be a suitable approach.

Metformin for Treating Diabetes

Metformin is generally a good first-line drug for type 2 diabetes. It appears to reduce the cumulative insulin and IGF-1 exposures. That clearly is desirable. However, in some cohorts—older individuals with a lower body mass index, for instance— metformin was no better than placebo in preventing diabetes. The stage for the development of Type 2 diabetes is set by long-standing insulin toxicity. So my goal in caring for individuals with type 2 diabetes is help them de-grease the cell membranes to free up insulin receptor protein embedded in the grease, eliminate insulin toxicity, and seakk de-diabetization. In this setting, I am not interested in prescribing Metformin. Rather, I want to safely discontinue all anti-diabetes drugs, including Metformin. My approach then is radically different from the advice of Life Extension. This is why I consider the position taken by Life Extension injudicious at this time. I will gladly change it if and when it is warranted.

Metformin is tolerated well by most diabetics. It has few negative effects—stomach upset is the most common adverse effect—and carries a low risk of symptomatic episodes of low blood sugar (hypoglycemia). Buildup of lactic acid is an uncommon but serious adverse effect of the drug. Metformin does not address any of the issues of insulin toxicity and testosterone toxicity.


1. Julius Goepp. The drug virtually everyone shouls ask their doctor about. Life Extension, November, 2010.

2 Van Zile J. On building bridges toward immortality. Life Extension, September 2005, page 48.

3. Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346(6):393–403.

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