Category Archives: Dr’s Insulin Course

Is Diabetes Really A Sugar Problem? No.

 

Majid Ali, M.D.

New York  212-873-2444

New Jersey . 201-996-0027


 

No, Diabetes Is Not a Sugar Problem.

It is an insulin Problem.


Unless specified otherwise, the word at this web site is used for Type 2 diabetes.


 

BEWARE!

  1. If you think, diabetes is a sugar problem, tests done for blood sugar levels for screening for diabetes will be misleading most of the time.
  2. The diagnosis of diabetes will be delayed for five, ten, or more years.
  3. If you are overweight, it will be much more difficult to lose weight. 
  4. Unless you are at your optimal weight, undetected insulin toxicity will injure all your body organs to varying degrees until diabetes is diagnosed and treated for years, usually five to ten or more years.

 

Large Scientific Claims Require Large Scientific Evidence

The Common Diabetes Is Not a Sugar Problem, But An Insulin Toxicity Problem.


Table 2. Insulin Homeostasis Categories in 506 Study Subjects Without Type 2 Diabetes
Insulin Category*
Percentage of Subgroup
Mean Peak Glucose mg/dL
(mmol/mL)
Mean Peak Insulin (uIU/mL)
Exceptional Insulin Homeostasis,N =  12
1.7%
110.2
14.3
Optimal Homeostasis,N=  126
24.9 %
121.2
26.7
Hyperinsulinism, Mild,       N =  197
38.9 %
136.5
58.5
Hyperinsulinism, Moderate,  N =  134
26.5 %
147.0 
109.1
Hyperinsulinism, 
Severe,  N =  49

9.7 %

150.0

1.3 – Fold Increase

231.0

17-Fold Increase

#   Correlation coefficient, r value, for means of peak glucose and insulin levels in the five insulin categories is 0.84.
*Criteria for classification: (1) Exceptional insulin homeostasis, a subgroup of optimal insulin homeostasis with fasting insulin concentration of <2 uIU/mL and mean peak insulin concentration of <20; (2) optimal insulin homeostasis, peak insulin <40 accompanied by unimpaired glucose tolerance; (3) mild

Large Scientific Claims Require Large Scientific Evidence

The Common Diabetes Is Not a Sugar Problem, But An Insulin Toxicity Problem. 

Table 3. Insulin Homeostasis Categories in 178 Study Subjects With Type 2 Diabetes
Insulin Category
Percentage of Subgroup
Mean Peak Glucose, mg/dL
(mmol/mL)
Mean Peak Insulin (uIU/mL)
Diabetic Hyperinsulinism, Mild,           N =  53
29.0%
252.0   (14.00)

55.4

Diabetic Hyperinsulinism, Moderate    N =  42
24.0%
242.1   (13.45)

112.4

Diabetic Hyperinsulinism, Severe          N =  24
13.9%
224.6   (12.47)

298.0

Diabetic  Insulin Deficit                             N =  59
33.1%
294.0    (16.33)

22.9


How Absurd Can the Lab Normal Ranges Become?

Insulin Reference Ranges  in uIU/mL of Six Laboratories in New York Metropolitan Area*
Laboratory
 
 
Fasting
 
 
1 Hr
 
 
2 Hr
 
 
3 Hr
 
 
Laboratory 1
 
1.9 – 23
 
8  –  112
 
5 – 35
 
Not Reported
 
Laboratory 2
 
2.6 – 24.9
 
0.0  – 121.9
 
0.0 – 163.5
 
Not Reported
 
Laboratory 3 
 
2.6 – 24.9
 
8  –  112
 
5  –  55
 
3  –  20
 
Laboratory 4
 
6  – 27
 
20  –  120
 
18  –  56
 
8  –  22
 
Laboratory  5
 
00  – 30
 
30  –  200
 
40  – 300
 
50  – 150
 
Laboratory 6
 
Does not include insulin ranges in the report. Instead it includes the following note: Insulin analogues may demonstrate non-linear cross-reactivity in this essay. Interpret results accordingly.**
*Upper and lower limits of laboratory reference ranges for blood insulin concentration determined following a Standard 75-gram glucose challenge.
**Personal communications with clinicians revealed that they do not find this laboratory note to be satisfactory in their clinical decision-making.

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References for Insulin Toxicity and Diabetes 

  1. Ali M. Fayemi AO, Ali O, Dasoju S, et al. Shifting Focus From Glycemic Status to Insulin Homeostasis for Stemming Global Tides of Hyperinsulinism and Type 2 Diabetes. Townsend Letter. 2017; 402:91-96.
  2. Ali M. Importance of Subtyping Type 2 Diabetes Into Subtype A and Subtype 2A and Subtype 2B.  Townsend Letter. 2014; 369:56-58.
  3. Ali M, Dasoju S, Karim N, et al. Study of responses to carbhydrate and non-carbohydratechallenges in insulin-based care of metabolic disorders. Townsend Letter. 2016; 391: 48-51.

 

What IS Insulin Toxicity?

Blood insulin test should be done for the following conditions since there is high probability that the underlying fires of these conditions are fed by insulin toxicity.

 

·       Loss of Vigor

·       Weight gain

·       Course skin

·       Acne in teenager

        Skin pigmentation changes

·       Facial hour for young women

·       Tingling and numbness in toes and fingers

·       Brain fog

·       Cognitive difficulties

·       Memory loss

·       Any infections that do not heal

·       Any inflammation that does not heal

·       Colitis of immune-inflammatory disorders

·       Arthritis of immune-inflammatory disorders

·       Connective tissue diseases

·       Any skin conditions that do not heal

·       Neurodermatitis

·       Brain atrophy

·       Brain degenerative conditions

·       Rising blood creatinine level

·       Rising liver enzyme levels

·       Rising CRP test results

·       Liver ultrasound with fatty liver disease, steatosis, or steatonecrosis.


 

Blood Cells Tell The Insulin Toxicity Story

Healthy Blood Cells for Comparative Study. Figure 1

Early Stress on Red Blood Cells (lower picture) . Figure 2

.


 

Microplaques in Circulating Blood

When Blood Glucose Level Rises Above 200 mg/dL 

Figure 13 (top) and figure 14 (bottom) show two microplaques in a patient who had received three unsuccessful angioplasties for advanced IHD. Photomicrographs were taken the day after a major nosebleed. Note the compaction of necrotic debris and blood elements in microplaques as contrasted with loose structure of microclots in figure 11.


 

 

 


Red Blood Cells in a Micro-clot In Uncontrolled Diabetes (upper Picture) Figure 3

Red Blood Cell Clot Breaking Up (lower Picture) Figure 4


Micro-plaque Formation In Uncontrolled Diabetes (both pictures) Figures 5-6


 

Figure 7 (top) illustrates severely damaged erythrocytes in a 52-year-old man with persistent atrial fibrillation. Close examination shows some zones of congealing surrounding many damaged red blood cells.

Figure 8 (bottom) illustrates a zone of plasma congealing unaccompanied by any cellular elements of the blood (seemingly a “spontaneous” phenomenon) in a diabetic with IHD. In our view, such congealing represents accelerated oxidative stress on plasma.


 

Figure 9 (top) shows some needle-like and amorphous granular microclots in a patient with unstable angina.

Figure 10 (bottom) shows a “dirty” blood smear of a man with severe peripheral vascular disease and extensive bilateral leg ulcerations, showing zones of plasma congealing and lumpiness, platelet clumping, and some other zones of plasma congealing unaccompanied by any blood corpuscular elements, representing diffuse changes of AA oxidopathy.


 

Figure 11 (top) shows a microclot formed by a large aggregate of platelets and congealed plasma in a patient five days after angioplasty.

Figure 12 (bottom) shows another field from the same smear and illustrates how microclots in oxidative coagulopathy grow in size when oxidative stress persists.


 

Figure 13 (top) and figure 14 (bottom) show two microplaques in a patient who had received three unsuccessful angioplasties for advanced IHD. Photomicrographs were taken the day after a major nosebleed. Note the compaction of necrotic debris and blood elements in microplaques as contrasted with loose structure of microclots in figure 11.

 


References for Oxygen, Inflammation, Insulin, and Diverse Diseases

 

1.    Ali M. Spontaneity of Oxidation in Nature and Aging, (monograph). Teaneck, NJ, 1983.

2.    Ali M. Leaky Cell Membrane Disorder (monograph). Teaneck, NJ, 1987.

3.    Ali M. The agony and death of a cell. In: Syllabus of the Instruction Course of the American Academy of Environmental Medicine. Denver, Colorado, 1985.

4.    Ali M. Molecular medicine. In: The Cortical Monkey and Healing. Institute of Preventive Medicine, Bloomfield, NJ, 1990.

5.    Ali M. Ascorbic acid reverses abnormal erythrocyte morphology in chronic fatigue syndrome, Am J Clin Pathol. I990;94:5I5.

6.    Ali M. Ascorbic acid prevents platelet aggregations by norepinephrinc, collagen, ADP and ristocetin. Am J Clin Pathol 1991;95:281.

7.    Ali M. The basic equation of life. In: The Butterfly and Life Span Nutrition. The Institute of Preventive Medicine Press, Denville, New Jersey. pp 225-236, 1992,

8.    Ali M. Oxidative theory of cell membrane and plasma damage. In Rats, Drugs and Assumptions. 1995. Life Span, Denville, New Jersey. pp 281-302, 1995.

9.    Ali M, Ali O. AA oxidopathy: the core pathogenetic mechanism of ischemic heart disease. J Integrative Medicine 1997;1:1-112.

10.  Ali M. Ali O. Oxidative coagulopathy in fibromyalgia and chronic fatigue syndrome. Am J Clin Pathol 1999; 112:566-7.

11.  Ali M, Ali O. Fibromyalgia: An oxidative-dysoxygenative disorder (ODD) J Integrative Medicine, 1999;1:1717.

12.  Ali M. Syllabus of capital University of Integrative Medicine, 1997 Washington, DC.

13.  Ali M. Oxidative regression to primordial cellular ecology (ORPEC): Evidence for the hypothesis and its clinical significance. J Integrative Medicine 1988;2:4-55.

14.  Ali M. Primacy of the erythrocyte in vascular ecology. J Integrative Medicine. 2000;3:5-18.

15.  Ali M. The Oxidative-dysoxygenative perspective of apoptosis. J Integ Medicine. 2000;4:5-45.

16.  Ali M, Ali 0, Fayemi A, et al: Improved myocardial perfusion in patients with advanced ischemic heart disease with an integrative management program including EDTA chelation therapy. J Integrative Medicine. 1997;1:113-145.

17.  Ali M: Hypothesis: Chronic fatigue is a state of accelerated oxidative molecular injury. J Advancement in Medicine, 1993;6:83-96.

18.  Efficacy of ecologic-integrative management protocols for reversal of fibromyalgia: an open prospective study of 150 patients. J Integrative Med 1999:3:48-64.

19.  Ali M. Oxidative coagulopathy In environmental illness. Environmental Management and Health. 2000;11:175-191.

20.  All Recent advances in integrative allergy care. Current Opinion in Otolaryngology & Head and Neck Surgery 2000:8:260-266.

21.  Ali M. The agony and death of a cell. Syllabus of the instructional course of the American Academy of Environmental Medicine Denver, Co. 1985.

22.  Ali M. Intravenous Nutrient protocols in Nutritional Medicine, (monograph). Institute of Preventive Medicine. Denville, New Jersey 1991.

23.  Ali M. Oxidative theory of cancer. In: Rats, Drugs and Assumptions. 1995. Life Span, Denville, New Jersey. pp 1995:281-302

24.  Ali M. Amenorrhea, oligomenorrhea, and polymenorrhea in CFS and fibromyalgia are caused by oxidative menstrual dysfunction. J Integrative Medicine 1998;3:101-124.

25.  Ali M, Ali 0, Fayemi A, et al: Efficacy of an integrative program including intravenous and intramuscular nutrient therapies for arrested growth. J Integrative Medicine 1998:2:56-69.

26.  Ali M. Oxidative theory of cell membrane and plasma damage. In: Rats, Drugs and Assumptions. Life Span, Denville, New Jersey, 1995:281-302.

27.  Ali M. Darwin, oxidosis, dysoxygenosis, and integration. J Integrative Medicine l999;1:11-16

28.  Ali M. Darwin, Oxidosis, Dysoxygenosis, and Integration. J Integrative Medicine. 1999;3:11-16.

Majid Ali, M.D.

New York  212-873-2444

New Jersey . 201-996-0027


 

Unless specified otherwise,

the word at this web site is used for Type 2 diabetes.


 

BEWARE!

  1. If you think, diabetes is a sugar problem, tests done for blood sugar levels for screening for diabetes will be misleading most of the time.
  2. The diagnosis of diabetes will be delayed for five, ten, or more years.
  3. If you are overweight, it will be much more difficult to lose weight. 
  4. Unless you are at your optimal weight, undetected insulin toxicity will injure all your body organs to varying degrees until diabetes is diagnosed and treated for years, usually five to ten or more years.

 

References for Insulin Toxicity and Diabetes 

  1. Ali M. Fayemi AO, Ali O, Dasoju S, et al. Shifting Focus From Glycemic Status to Insulin Homeostasis for Stemming Global Tides of Hyperinsulinism and Type 2 Diabetes. Townsend Letter. 2017; 402:91-96.
  2. Ali M. Importance of Subtyping Type 2 Diabetes Into Subtype A and Subtype 2A and Subtype 2B.  Townsend Letter. 2014; 369:56-58.
  3. Ali M, Dasoju S, Karim N, et al. Study of responses to carbhydrate and non-carbohydratechallenges in insulin-based care of metabolic disorders. Townsend Letter. 2016; 391: 48-51.

 

What IS Insulin Toxicity

Blood insulin test should be done for the following conditions since there is high probability that the underlying fires of these conditions are fed by insulin toxicity.

 

·       Loss of Vigor

·       Weight gain

·       Course skin

·       Acne in teenager

        Skin pigmentation changes

·       Facial hour for young women

·       Tingling and numbness in toes and fingers

·       Brain fog

·       Cognitive difficulties

·       Memory loss

·       Any infections that do not heal

·       Any inflammation that does not heal

·       Colitis of immune-inflammatory disorders

·       Arthritis of immune-inflammatory disorders

·       Connective tissue diseases

·       Any skin conditions that do not heal

·       Neurodermatitis

·       Brain atrophy

·       Brain degenerative conditions

·       Rising blood creatinine level

·       Rising liver enzyme levels

·       Rising CRP test results

·       Liver ultrasound with fatty liver disease, steatosis, or steatonecrosis.


 

Blood Cells Tell The Insulin Toxicity Story

Healthy Blood Cells for Comparative Study. Figure 1

Early Stress on Red Blood Cells (lower picture) . Figure 2


Red Blood Cells in a Micro-clot In Uncontrolled Diabetes (upper Picture) Figure 3

Red Blood Cell Clot Breaking Up (lower Picture) Figure 4


Micro-plaque Formation In Uncontrolled Diabetes (both pictures) Figures 5-6


 

Figure 7 (top) illustrates severely damaged erythrocytes in a 52-year-old man with persistent atrial fibrillation. Close examination shows some zones of congealing surrounding many damaged red blood cells.

Figure 8 (bottom) illustrates a zone of plasma congealing unaccompanied by any cellular elements of the blood (seemingly a “spontaneous” phenomenon) in a diabetic with IHD. In our view, such congealing represents accelerated oxidative stress on plasma.


 

Figure 9 (top) shows some needle-like and amorphous granular microclots in a patient with unstable angina.

Figure 10 (bottom) shows a “dirty” blood smear of a man with severe peripheral vascular disease and extensive bilateral leg ulcerations, showing zones of plasma congealing and lumpiness, platelet clumping, and some other zones of plasma congealing unaccompanied by any blood corpuscular elements, representing diffuse changes of AA oxidopathy.


 

Figure 11 (top) shows a microclot formed by a large aggregate of platelets and congealed plasma in a patient five days after angioplasty.

Figure 12 (bottom) shows another field from the same smear and illustrates how microclots in oxidative coagulopathy grow in size when oxidative stress persists.


 

Figure 13 (top) and figure 14 (bottom) show two microplaques in a patient who had received three unsuccessful angioplasties for advanced IHD. Photomicrographs were taken the day after a major nosebleed. Note the compaction of necrotic debris and blood elements in microplaques as contrasted with loose structure of microclots in figure 11.

 


References for Oxygen, Inflammation, Insulin, and Diverse Diseases

 

1.    Ali M. Spontaneity of Oxidation in Nature and Aging, (monograph). Teaneck, NJ, 1983.

2.    Ali M. Leaky Cell Membrane Disorder (monograph). Teaneck, NJ, 1987.

3.    Ali M. The agony and death of a cell. In: Syllabus of the Instruction Course of the American Academy of Environmental Medicine. Denver, Colorado, 1985.

4.    Ali M. Molecular medicine. In: The Cortical Monkey and Healing. Institute of Preventive Medicine, Bloomfield, NJ, 1990.

5.    Ali M. Ascorbic acid reverses abnormal erythrocyte morphology in chronic fatigue syndrome, Am J Clin Pathol. I990;94:5I5.

6.    Ali M. Ascorbic acid prevents platelet aggregations by norepinephrinc, collagen, ADP and ristocetin. Am J Clin Pathol 1991;95:281.

7.    Ali M. The basic equation of life. In: The Butterfly and Life Span Nutrition. The Institute of Preventive Medicine Press, Denville, New Jersey. pp 225-236, 1992,

8.    Ali M. Oxidative theory of cell membrane and plasma damage. In Rats, Drugs and Assumptions. 1995. Life Span, Denville, New Jersey. pp 281-302, 1995.

9.    Ali M, Ali O. AA oxidopathy: the core pathogenetic mechanism of ischemic heart disease. J Integrative Medicine 1997;1:1-112.

10.  Ali M. Ali O. Oxidative coagulopathy in fibromyalgia and chronic fatigue syndrome. Am J Clin Pathol 1999; 112:566-7.

11.  Ali M, Ali O. Fibromyalgia: An oxidative-dysoxygenative disorder (ODD) J Integrative Medicine, 1999;1:1717.

12.  Ali M. Syllabus of capital University of Integrative Medicine, 1997 Washington, DC.

13.  Ali M. Oxidative regression to primordial cellular ecology (ORPEC): Evidence for the hypothesis and its clinical significance. J Integrative Medicine 1988;2:4-55.

14.  Ali M. Primacy of the erythrocyte in vascular ecology. J Integrative Medicine. 2000;3:5-18.

15.  Ali M. The Oxidative-dysoxygenative perspective of apoptosis. J Integ Medicine. 2000;4:5-45.

16.  Ali M, Ali 0, Fayemi A, et al: Improved myocardial perfusion in patients with advanced ischemic heart disease with an integrative management program including EDTA chelation therapy. J Integrative Medicine. 1997;1:113-145.

17.  Ali M: Hypothesis: Chronic fatigue is a state of accelerated oxidative molecular injury. J Advancement in Medicine, 1993;6:83-96.

18.  Efficacy of ecologic-integrative management protocols for reversal of fibromyalgia: an open prospective study of 150 patients. J Integrative Med 1999:3:48-64.

19.  Ali M. Oxidative coagulopathy In environmental illness. Environmental Management and Health. 2000;11:175-191.

20.  All Recent advances in integrative allergy care. Current Opinion in Otolaryngology & Head and Neck Surgery 2000:8:260-266.

21.  Ali M. The agony and death of a cell. Syllabus of the instructional course of the American Academy of Environmental Medicine Denver, Co. 1985.

22.  Ali M. Intravenous Nutrient protocols in Nutritional Medicine, (monograph). Institute of Preventive Medicine. Denville, New Jersey 1991.

23.  Ali M. Oxidative theory of cancer. In: Rats, Drugs and Assumptions. 1995. Life Span, Denville, New Jersey. pp 1995:281-302

24.  Ali M. Amenorrhea, oligomenorrhea, and polymenorrhea in CFS and fibromyalgia are caused by oxidative menstrual dysfunction. J Integrative Medicine 1998;3:101-124.

25.  Ali M, Ali 0, Fayemi A, et al: Efficacy of an integrative program including intravenous and intramuscular nutrient therapies for arrested growth. J Integrative Medicine 1998:2:56-69.

26.  Ali M. Oxidative theory of cell membrane and plasma damage. In: Rats, Drugs and Assumptions. Life Span, Denville, New Jersey, 1995:281-302.

27.  Ali M. Darwin, oxidosis, dysoxygenosis, and integration. J Integrative Medicine l999;1:11-16

28.  Ali M. Darwin, Oxidosis, Dysoxygenosis, and Integration. J Integrative Medicine. 1999;3:11-16.


 

Coronary Heart Disease Is Not a Plumbing Problem

Majid Ali, M.D.

New York  212-873-2444

New Jersey . 201-996-0027


 

Endo Health for Vascular Health

Oxygen-Insulin Signaling Matrix

Insulin-Endotoxicity and Cardiovascular Diseases


Two Enemies of the Heart: Conflict and Anger

Conflict cannot be cleared by letting the steam out.

Anger sometimes can be cleared by letting the steam out.


Clearer the Knowledge,

Better the Cardiovascular Health

Two Critical Links: the More the Coronary Plaques, Fewer the Heart Deaths 

The More-Coronary-Plaques-Fewer-Deaths Paradox

Conviction Concerning the Oxygen-Insulin Signaling Matrix


What Is Endothelium?

What Are Good Endo Spices?

What Are Good Endo Herbs


 

What Hurts Endos Most?

Perverted Oxygen-Insulin Signaling Matrix.


 

Crucial Endo Factors

Endothelium Maintains the Vasodilation and Vasoconstriction Balance

inhibition and promotion of the migration and proliferation of smooth muscle cells, fibrinolysis and thrombogenesis as well as prevention and stimulation of the adhesion and aggregation of platelets.


 

What Are Endos?

The vascular endothelium is a multifunctional organ and is critically involved in modulating vascular tone and structure. Endothelial cells produce a wide range of factors that also regulate cellular adhesion, thromboresistance, smooth muscle cell proliferation, and vessel wall inflammation. Thus, endothelial function is important for the homeostasis of the body and its dysfunction is associated with several pathophysiological conditions, including atherosclerosis, hypertension and diabetes. Patients with diabetes invariably show an impairment of endothelium-dependent vasodilation.


Endo Workers

  1.  Reactive Oxygen Species
  2.  Nitric Oxide
  3. Angiotensin II
  4.  EDHF      Endothelium-derived Hyperpolarization Factor
  5. .  Prostacyclin (PGI2
  6.    Antithrombotic (NO and PGI2 both inhibit platelet aggregation) 
  7.   Prothrombotic molecules [von Willebrand factor,
  8.   Plasminogen activator inhibitor-1 (PAI-1)

 

Nitric oxide

NO is a crucial player in vascular homeostasis. NO is synthesized within endothelial cells during conversion of l-arginine to l-citrulline by endothelial nitric oxide synthase (eNOS) [15]. It is released from endothelial cells mainly in response to shear stress elicited by the circulating blood or receptor-operated substances such as acetylcholine, bradykinin, or serotonin [16]. NO diffuses to vascular smooth muscle cells (VSMC) and activates soluble guanylate cyclase (sGC), yielding increased levels of cyclic guanosine-3,5-monophosphate (cGMP) and relaxation of VSMC [1,17]. Additionally, NO also prevents leukocyte adhesion and migration, smooth muscle cell proliferation, platelet adhesion and aggregation, and opposes apoptosis and inflammation having an overall antiatherogenic effect (Fig. 3) [18].


 Therefore, understanding and treating endothelial dysfunction is a major focus in the prevention of vascular complications associated with all forms of diabetes mellitus. The mechanisms of endothelial dysfunction in diabetes may point to new management strategies for the prevention of cardiovascular disease in diabetes. This review will focus on the mechanisms and therapeutics that specifically target endothelial dysfunction in the context of a diabetic setting. Mechanisms including altered glucose metabolism, impaired insulin signaling, low-grade inflammatory state, and increased reactive oxygen species generation will be discussed. The importance of developing new pharmacological approaches that upregulate endothelium-derived nitric oxide synthesis and target key vascular ROS-producing enzymes will be highlighted and new strategies that might prove clinically relevant in preventing the development and/or retarding the progression of diabetes associated vascular complications.


Decreased formation of NO

eNOS is a dimeric enzyme depending on multiple cofactors for its physiological activity and optimal function. eNOS resides in the caveolae and is bound to the caveolar protein, caveolin-1 that inhibits its activity. Elevations in cytoplasmic Ca2 + promote binding of calmodulin to eNOS that subsequently displaces caveolin and activates eNOS


 

Vascular Function and Endothelium

The endothelium is a monolayer of cells covering the vascular lumen. For many years this cell layer was thought to be relatively inert, a mere physical barrier between circulating blood and the underlying tissues. It is now recognized, however, that endothelial cells are metabolically active with important paracrine, endocrine and autocrine functions, indispensable for the maintenance of vascular homeostasis under physiological conditions [1,2]. The multiple functions of vascular endothelium are summarized in Fig. 1 and include regulation of vessel integrity, vascular growth and remodeling, tissue growth and metabolism, immune responses, cell adhesion, angiogenesis, hemostasis and vascular permeability. The endothelium plays a pivotal role in the regulation of vascular tone, controlling tissue blood flow and inflammatory responses and maintaining blood fluidity.


 

Crucial Endo Factors

Endothelium Maintains the Vasodilation and Vasoconstriction Balance

, inhibition and promotion of the migration and proliferation of smooth muscle cells, fibrinolysis and thrombogenesis as well as prevention and stimulation of the adhesion and aggregation of platelets.


  1.  Reactive Oxygen Species
  2. Nitric Oxide
  3. Angiotensin II
  4.  EDHF      Endothelium-derived Hyperpolarization Factor
  5. .  Prostacyclin (PGI2
  6.    Antithrombotic (NO and PGI2 both inhibit platelet aggregation) 
  7.   Prothrombotic molecules [von Willebrand factor,
  8.   Plasminogen activator inhibitor-1 (PAI-1)

Endothelium-derived factors with vasodilatory and antiproliferative effects include endothelium-derived hyperpolarization factor (EDHF) [], nitric oxide (NO) [8,9] and prostacyclin (PGI2) [10], while endothelin-1 (ET-1) [11], angiotensin II and reactive oxygen species (ROS) are among the mediators that exert vasoconstrictor effects [12,13]. Endothelial cells also produce antithrombotic (NO and PGI2 both inhibit platelet aggregation) and prothrombotic molecules [von Willebrand factor, which promotes platelet aggregation, and plasminogen activator inhibitor-1 (PAI-1), which inhibits fibrinolysis] [5].

As a major regulator of vascular homeostasis, the endothelium maintains the balance between vasodilation and vasoconstriction, inhibition and promotion of the migration and proliferation of smooth muscle cells, fibrinolysis and thrombogenesis as well as prevention and stimulation of the adhesion and aggregation of platelets (Fig. 2) [5]. Disturbing this tightly regulated equilibrium leads to endothelial dysfunction.


 

Many Faces of Endothelium

Fig. 1. Multiple functions of endothelium.


 

Spices and Herbs For Endo Health

 

 

 

 

 

 

 

 

Insulin Essentials

Majid Ali, M.D.

Very little of What I Learned About Diabetes In Medical School Has Been Validated by My Patients, My True Teachers.


 

Insulin Essentials

  1. Insulin is the master energy hormone of the body, for energy generation as well as energy expenditure.
  2. The energy demands of chronically-injured cells increase because repair of injured tissues needs more energy.
  3. Increased demands for cellular repair energy can be met only with increased supply of fuel (glucose) for producing more cellular energy.
  4. Higher demands for glucose require higher insulin activity.
  5. The validity of these statements can be tested only with direct blood insulin tests, not by doing blood tests for glucose (fasting blood glucose, A1c test, two-hour post-prandial blood sugar, or three-hour glucose tolerance test after a glucose load.
  6. other forms of sugar.
  7. Anyone can test the validity of the above statement with blood insulin tests.

 

What My Professors Did Not Tell Me About Insulin Essentials

  1. Newborn babies with birth weight larger than eight pounds are insulin toxic.
  2. Mothers of babies with birth weight larger than eight pounds are insulin toxic.
  3. Expecting moms with gestational diabetes are insulin-toxic and will remain so after delivering their babies for variable periods of time.
  4. Boys with widespread persistent acne are insulin-toxic.
  5.  Young girls with polycystic ovarian cystic syndrome are insulin-toxic.
  6. Nearly all obese children are insulin-toxic.
  7. Children and adults with fatty liver and steatosis are insulin-toxic.
  8. Most patients with pulmonary fibrosis, bronchiectasis, and active tuberculosis are insulin-toxic. 
  9. Most individuals with psoriasis and sarcoidosis are insulin-toxic.
  10. Most individuals with chronic autoimmune disorders (rheumatoid arthritis, lupus, scleroderma, and others) are insulin-toxic.
  11. Most patients with chronic renal failure are insulin-toxic.
  12. Most individuals with memory loss, dementia, Alzheimer’s disease, and diverse chronic diseases of the brain are insulin-toxic.
  13. Most individuals with cancer are insulin-toxic.
  14. Nearly all people become insulin-toxic after receiving chemotherapy.

 

 

  1. Individuals with psoriasis are insulin-toxic.
  2. babies with birth weight larger than eight pounds are insulin toxic.
  3. In

 

Reversing Diabetes D3 – Part A: The Diet Plan

Majid Ali, M.D.

A Simplified Yet Effective Choices in-the-Kitchen Part of Reversing Diabetes D3 Plan for Preventing and Reversing Diabetes Based on Authentic Science and Philosophy of Holism 


 

Reversing  Diabetes D3

                                               D   for Diet

                                               D   for Gut-Liver Detox

                                               D   for Dysoxic Co-morbidities* 

  • Dysoxic Co-morbidities is my term for coexisting oxygen-related conditions 

 

Reversing Diabetes D3 Diet Plan

  1. Dr. Ali’s Breakfast Shakes/Smoothies

  2. Lunch Options

  3. Dinner Suggestions

  4. Healthy Fats and Proteins Snack

  5. Recipes


The Wider Horizon

for Reversal of Chronic Disease

1. Love

2. Oxygen

3. Prayer

4. Insulin


Dr. Ali’s Insulin and Diabetes Library of Articles, DVD, and Video Seminars


 

Dr. Ali’s Breakfast 2017 | – Who Is Dr. Ali?

Oct 8, 2016 – Majid Ali, M.D. Majid Ali, M.D. Dr. Ali’s Breakfasts Are Ideas, Not Products We Value Your Suggestions. Please Send Them to …

Dr. Ali’s Start-Low-Build-Slow Principle | Ali Diabetes

Diabetes Reversal With Insulin Detox | Ali Diabetes

Jun 4, 2017 – Dr. Ali’s Breakfast for Losing Weight, Reversing Diabetes, and Staying … ….. Apr 18, 2017Majid Ali, M.D.Dr. Ali’s Insulin Homeostasis Course 

Diabetes Is Rooted In Insulin Toxicity – Part Two | Ali Diabetes

Jun 4, 2017 – Majid Ali, M.D. Diabetes Begins 15–20 years before it is diagnosed Text Reproduced … Dr.Ali’s Breakfastfor Losing Weight, Reversing Diabetes, and Staying … … alihealing.org/2017/05/24/low-insulin-levels-good-and-bad/.

Oxidation Model of Diabetes Validated – 20 Years Later | Ali Diabetes

Jun 5, 2017 – Majid Ali, M.D. I published my oxidative model of diabetes in 1995. … Oct 31, 2014 – Dr.Ali’s Breakfast I consider an optimal breakfast to be the first essential in any … … https://alidiabetes.org/2017/04/18/insulin-homeostasis/.

Dr’s Insulin Course | Ali Diabetes

May 31, 2017 – https://alidiabetes.org/2017/04/23/what-is-insulin-homeostasis/. Apr 23 … Apr 18, 2017Majid Ali, M.D.Dr. Ali’s Insulin Homeostasis Course Insulin | The Ali Academy Community ….. Dr. Ali’sBest Anti-Insulin ToxicityBreakfast.

Dr. Ali’s Start-Low-Build-Slow Principle | Ali Diabetes

Majid Ali, M.D. Dr. Ali’s Start-Low-Build-Slow Principle In all guidelines for natural remedies for … Posted on April 24,2017 by Majid Ali MD Leave a comment.

Dr Ali Breakfast videos part 1 | The Ali Academy Community

Dr. Ali, Your Breakfast Is Great!! Majid Ali MD An Excellent Anti-diabetes Breakfast Majid Ali MD Lecithin for Dr. Ali’s Breakfast Majid Ali MD More Energy With Dr.

Dr. Ali’s Insulin Reduction Protocol

Majid Ali, M.D. … Concurrent Reduction of Blood Insulin and Blood Sugar Levels With Dr. Ali’s Insulin Reduction Protocol in a 58-Yr-Old Woman … Please consider “Dr. Ali’s Breakfast” (protein shake described below) four or five days a week.

 


 

 


Dr. Ali’s Breakfast 2017 | – Who Is Dr. Ali?

Oct 8, 2016 – Majid Ali, M.D. Majid Ali, M.D. Dr. Ali’s Breakfasts Are Ideas, Not Products We Value Your Suggestions. Please Send Them to …

Dr. Ali’s Breakfast 2017 | – Who Is Dr. Ali?

Oct 8, 2016 – Posts about Dr. Ali’s Breakfast 2017 written by Majid Ali MD.

Dr. Ali’s Insulin-Wise Breakfast – Dr. Ali’s Virtual Medical Library

drali1.org/dr__ali’s_breakfast.htm

Indeed, next to the subject of chronic anger I devote more time energy—and energy— to the matter of “Dr. Ali’s breakfast” than any other subject. In this chapter, I …

Majid Ali MD, Dr. Ali’s 5- Spices Yogurt Breakfast for Reversing …

https://vimeo.com › Majid Ali › Videos
Oct 30, 2014

I describe my 5 Spices Yogurt Breakfast and recommend its inclusion in my Insulin-Monitored Diabetes …

Weight Loss With Dr. Ali’s Breakfast Majid Ali MD on Vimeo

https://vimeo.com › Majid Ali › Videos
Apr 23, 2014

Professor Majid Ali shares information about “Weight Loss With Dr. Ali’s Breakfast

Will Dr. Ali’s Breakfast Reverse Heart Disease Majid Ali MD on Vimeo

https://vimeo.com › Majid Ali › Videos
Apr 24, 2014

Professor Majid Ali shares information about “Will Dr. Ali’s Breakfast Reverse Heart Disease”

Fish Oil for Dr. Ali’s Breakfast Majid Ali MD on Vimeo

https://vimeo.com › Majid Ali › Videos
May 12, 2014

Professor Majid Ali shares information about “Fish Oil for Dr. Ali’s Breakfast

Lecithin for Dr. Ali’s Breakfast Majid Ali MD on Vimeo

https://vimeo.com › Majid Ali › Videos
Apr 19, 2014

Professor Majid Ali shares information about “Lecithin for Dr. Ali’s Breakfast

Majid Ali MD, Dr. Ali’s Spicy Anti-Diabetes Breakfasts on Vimeo

https://vimeo.com › Majid Ali › Videos
Jan 28, 2015

Please try my spice breakfast suggestions. I don’t think they will disappoint you.

DR ALI’S OMELETTE RECIPES | Ali Diabetes

Posted on April 23, 2017 by Majid Ali MD Leave a comment. Majid AliDr Ali’s Best Omelette Recipes for Weight loss and Preventing and Reversing Diabetes.



Diabetes Reversal With Insulin Detox | Ali Diabetes

Jun 4, 2017 – Dr. Ali’s Breakfast for Losing Weight, Reversing Diabetes, and Staying … ….. Apr 18, 2017Majid Ali, M.D.Dr. Ali’s Insulin Homeostasis Course …

Diabetes Is Rooted In Insulin Toxicity – Part Two | Ali Diabetes

Jun 4, 2017 – Majid Ali, M.D. Diabetes Begins 15–20 years before it is diagnosed Text Reproduced … Dr.Ali’s Breakfastfor Losing Weight, Reversing Diabetes, and Staying … … alihealing.org/2017/05/24/low-insulin-levels-good-and-bad/.

Oxidation Model of Diabetes Validated – 20 Years Later | Ali Diabetes

Jun 5, 2017 – Majid Ali, M.D. I published my oxidative model of diabetes in 1995. … Oct 31, 2014 – Dr.Ali’s Breakfast I consider an optimal breakfast to be the first essential in any … … https://alidiabetes.org/2017/04/18/insulin-homeostasis/.

Dr’s Insulin Course | Ali Diabetes

May 31, 2017 – https://alidiabetes.org/2017/04/23/what-is-insulin-homeostasis/. Apr 23 … Apr 18, 2017Majid Ali, M.D.Dr. Ali’s Insulin Homeostasis Course Insulin | The Ali Academy Community ….. Dr. Ali’sBest Anti-Insulin ToxicityBreakfast.

Dr. Ali’s Start-Low-Build-Slow Principle | Ali Diabetes

Majid Ali, M.D. Dr. Ali’s Start-Low-Build-Slow Principle In all guidelines for natural remedies for … Posted on April 24,2017 by Majid Ali MD Leave a comment.

Dr Ali Breakfast videos part 1 | The Ali Academy Community

Dr. Ali, Your Breakfast Is Great!! Majid Ali MD An Excellent Anti-diabetes Breakfast Majid Ali MD Lecithin for Dr. Ali’s Breakfast Majid Ali MD More Energy With Dr.

Dr. Ali’s Insulin Reduction Protocol

Majid Ali, M.D. … Concurrent Reduction of Blood Insulin and Blood Sugar Levels With Dr. Ali’s Insulin Reduction Protocol in a 58-Yr-Old Woman … Please consider “Dr. Ali’s Breakfast” (protein shake described below) four or five days a week.

 


 

 


Dr. Ali’s Breakfast 2017 | – Who Is Dr. Ali?

Oct 8, 2016 – Majid Ali, M.D. Majid Ali, M.D. Dr. Ali’s Breakfasts Are Ideas, Not Products We Value Your Suggestions. Please Send Them to …

Dr. Ali’s Breakfast 2017 | – Who Is Dr. Ali?

Oct 8, 2016 – Posts about Dr. Ali’s Breakfast 2017 written by Majid Ali MD.

Dr. Ali’s Insulin-Wise Breakfast – Dr. Ali’s Virtual Medical Library

drali1.org/dr__ali’s_breakfast.htm

 

Indeed, next to the subject of chronic anger I devote more time energy—and energy— to the matter of “Dr. Ali’s breakfast” than any other subject. In this chapter, I …

Majid Ali MD, Dr. Ali’s 5- Spices Yogurt Breakfast for Reversing …

https://vimeo.com › Majid Ali › Videos
Oct 30, 2014

I describe my 5 Spices Yogurt Breakfast and recommend its inclusion in my Insulin-Monitored Diabetes …

 

Weight Loss With Dr. Ali’s Breakfast Majid Ali MD on Vimeo

https://vimeo.com › Majid Ali › Videos
Apr 23, 2014

Professor Majid Ali shares information about “Weight Loss With Dr. Ali’s Breakfast

 

Will Dr. Ali’s Breakfast Reverse Heart Disease Majid Ali MD on Vimeo

https://vimeo.com › Majid Ali › Videos
Apr 24, 2014

Professor Majid Ali shares information about “Will Dr. Ali’s Breakfast Reverse Heart Disease”

 

Fish Oil for Dr. Ali’s Breakfast Majid Ali MD on Vimeo

https://vimeo.com › Majid Ali › Videos
May 12, 2014

Professor Majid Ali shares information about “Fish Oil for Dr. Ali’s Breakfast

 

Lecithin for Dr. Ali’s Breakfast Majid Ali MD on Vimeo

https://vimeo.com › Majid Ali › Videos
Apr 19, 2014

Professor Majid Ali shares information about “Lecithin for Dr. Ali’s Breakfast

 

Majid Ali MD, Dr. Ali’s Spicy Anti-Diabetes Breakfasts on Vimeo

https://vimeo.com › Majid Ali › Videos
Jan 28, 2015

Please try my spice breakfast suggestions. I don’t think they will disappoint you.

 

DR ALI’S OMELETTE RECIPES | Ali Diabetes

Posted on April 23, 2017 by Majid Ali MD Leave a comment. Majid AliDr Ali’s Best Omelette Recipes for Weight loss and Preventing and Reversing Diabetes.


 
 

 

Library of Articles On Insulin Homeostasis

 

Majid Ali, M.D.


What Is Insulin Homeostasis? | Ali Diabetes

Apr 23, 2017 – Majid Ali, M.D. Insulin is the minister of energy and metabolism to Oxygen King of the human body. So I define insulin homeostasis as body …

Insulin Homeostasis | Ali Diabetes

Apr 18, 2017 – Majid Ali, M.D. Dr. Ali’s Insulin Homeostasis Course Insulin | The Ali Academy Community https://majidalimd.me/category/insulin/ Nov 30, 2014 …

What Is Insulin Homeostasis? | Ali Diabetes

Jan 13, 2017 – So insulin homeostasis means optimal functionalities of the energy … Majid Ali MD, Voices From the Pre-East Course Part 1 – Introduction.

Shifting Focus From Glycemic Status to Insulin Homeostasis (Jan 2017 …

Shifting Focus From Glycemic Status to Insulin Homeostasis for Stemming Global Tides of Hyperinsulinism and Type 2 Diabetes by Majid Ali, MD, FRCS (Eng), …

Dr. Ali’s Insulin Reduction Protocol

Majid Ali, M.D. … Concurrent Reduction of Blood Insulin and Blood Sugar Levels With Dr. Ali’s InsulinReduction Protocol in …. Insulin Homeostasis and Diabetes.

Insulin Homeostasis and Diabetes

insulininstitute.org/insulin_homeostasis_and_diabetes.htm

Insulin Homeostasis and Diabetes. Majid Ali, M.D.. Related Artilces. * Oxygen Homeostasis and Oxygen Models of Diseases. * Insulin Homeostasis and …

I Have Diabetes, I have to Lose it – Part One: Insulin Toxicity | The Ali …

by M Ali – ‎Related articles

May 1, 2014 – Diabetes: part 1 Insulin Toxicity Majid Ali, M.D. Diabetes Type 2, the … for assessinginsulin homeostasis and the metabolic status of the body, …

Joint pain from too much insulin | The Ali Academy Community

Feb 24, 2015 – Majid Ali, M.D Nature created inflammation to gently remind … inflammation, first and foremost, is one of the many face of oxygen homeostasis.

Low Insulin Levels – Good and Bad – alihealing.org

alihealing.org/2017/05/24/low-insulin-levels-good-and-bad/

6 days ago – Shifting Focus From Glycemic Status to Insulin Homeostasis for Stemming Global Tides of Hyperinsulinism and Type 2 Diabetes by Majid Ali, …

Dr. Ali’s Insulin Course — Blogs, Pictures, and more on WordPress

av.wordpress.com/tag/dr-alis-insulin-course/

Majid Ali, M.D.. Insulin is the minister of energy and metabolism to Oxygen King of the human body. So I define insulin homeostasis as body energetics in …


Ali Academy | Institute of Integrative Medicine

Nov 16, 2016 – Majid Ali, M.D. I coined the term oxygen signaling to refer to all … homeostasis (overall balance) and Insulin-based Diabetes Reversal Plan©.

Dr. Ali Course On Insulin Toxicity — Blogs, Pictures, and more on …

ia.wordpress.com/tag/dr-ali-course-on-insulin-toxicity/

Shifting Focus From Glycemic Status to Insulin Homeostasis for Stemming Global … Majid Ali, M.D., F.R.C.S. (Eng), F.A.C.P., Alfred O. Fayemi, M.D., MSc (Path), …

Reporting a comment for the article : Acetate mediates a microbiome …

http://www.nature.com › Journal home › Archive › Authors

Jun 9, 2016 – Majid Ali said: … The plan shifts the focus from glycemic status to insulin homeostasisand addresses … Ali M. Altered States of Bowel Ecology.

Importance of Subtyping Diabetes Type 2 – Dr. Ali’s Virtual Medical …

drali1.org/subtyping_diabetes_type_2_importance.htm

Majid Ali, M.D. … Diabetes Type 2A with insulin excess and diabetes Type 2B with … Normalizing Insulin Homeostasis By Freeing Up Insulin Receptor.

Oxygen Homeostasis – ENCOGNITIVE.COM

by M Ali – ‎Related articles

two illustrate the evolutionary insulin design, and the remaining two demonstrate serious consequences of. Oxygen. Homeostasis by Majid Ali, MD.

The Stress Related Male-Distribution Hair in Females – Majid Ali MD Life

Aug 27, 2014 – So in my model of integrative medicine, I look at all chronic disorders through the prisms of oxygen homeostasis and insulin regulation. In two …

Childrens Health – Home | Facebook

Majid Ali, M.D. My Three Top Priorities for Patients With Inflammatory … Shifting Focus From Glycemic Status to Insulin Homeostasis for Personal Health. Majid …

Instant Seminars with Majid Ali

aliacademy.org/what_can_your_ankles_say_about_your_liver.htm

Heart Disease Video Seminars with Majid Ali, M.D. Bundle Offers ….. video seminar, Professor Majid Ali, M.D. presents his Insulin-Reduction Protocol. …. He looks through the prism of oxygen homeostasis and oxygen signaling to define the …

Dr. Ali’s Books – Complete List of Writings Works | Books by Majid Ali …

Nov 7, 2014 – Majid Ali, M.D. The Principles and Practice of Integrative Medicine (14 Volumes) … Medicine: Nutrition Seen Through the Prism of Oxygen Homeostasis. … Medicine Volume XIII: Insulin-Monitored Diabetes Reversal Plan.


DR ALI’S OMELETTE RECIPES

Majid Ali, M.D.

Ideas, Not Products

A Line of Low-Cost, Time-efficient, Insulin-Smart Recipes
for Preserving Health, Reversing Hyperinsulinism, and Making Effort to Reverse Type 2 Diabetes


DR ALI’S OMELETTE RECIPES

I offer my line of omelettes which are delicious, low-cost, and time-efficient. But these are the primary advantages of my omelettes. My primary purpose is to help people achieve optimal metabolic and immune health, lose weight (when desired), prevent insulin toxicity and diabetes, and through these effects, improve resistance to infections and cardiovascular health.


Why Don’t You Give Cooking Times for Your Omelette Recipes?


Dr. Ali’s Chopped Onion Omelette


Dr. Ali’s Coconut-Raisin Omelette


My Spice Omelettes for Memory Concerns and Alzheimer’s Diseasze from Majid Ali on Vimeo.


My Preferred Spice Remedies Are Omelettes from Majid Ali on Vimeo.


Dr. Ali’s Ginger Omelette Part Two


Dr. Ali’s Spicy Garlic Omelette


Dr. Ali’s Turmeric Omelette


Dr. Ali’s Turmeric Insulin-friendly Omelette


Dr. Ali’s Turmeric-Raisin Insulin-friendly Omelette


Dr Ali’s Top Three Weight Loss and Anti-diabetes Omelettes


Dr Ali’s Best Omelette Recipes for Weight loss and Preventing and Reversing Diabetes


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