Category Archives: Path Away From Diabetes

The LOPI Way to Reversing Diabetes

Majid Ali, M.D.

The Love-Oxygen-Prayer-Insulin (LOPI) Way for Reversing Diabetes

Please consider this Path Away From Diabetes for yourself and for those you love. It is not a path of products. I is the path to truth, love, healing. and reversing diabetes.



L for love, O for oxygen, P for Prayer, and I for Insulin

LOPI Way for Reversing Diabetes


Insulin Toxicity of the Unborn

Majid Ali, M.D.

The incidence of pregnancy-associated insulin resistance is rising worldwide, I think it is appropriately designated as insulin toxicity of the unborn.

The incidence of pregnancy-associated insulin resistance is rising worldwide, and is commonly associated with many physiological bioenergetic, biochemical, metabolic, physiological, hematological and immunological alterations.  Many of the factors involved with these alterations render cell membranes resistant to the action of insulin.  At the end of healthy pregnancy, these changes are  reversible after delivery [1]. Healthy women pregnancy can be associated with resistance to the action of insulin on glucose uptake and utilization.


Here is an important link for expecting moms and dads


The Crank-Crank-Shaft Model

of Insulin Resistance Insulin Toxicity

Insulin resistance as the resistance of cells, most notably of the muscles, liver, and fatty tissue to the action of insulin. In 2000, I offered the analogy of a crank and crank-shaft to explain how insulin resistance develops. 

I proposed The Crank-Crank-Shaft Model of Insulin Toxicity to offer a simple and visual model to explain insulin resistance, excess insulin activity (hyperinsulinemia), and insulin toxicity. In simple words, the “crank of insulin” fails to turn the “crank-shaft of insulin receptor” protein embedded in the cell membrane. This happens when the cell membrane is covered with grease—the crank-shaft is rusted, turned, and twisted, so to speak—so rendering insulin ineffective. I point out that the insulin receptor crankshaft is roughly 70 times larger than the insulin crank.

To illustrate injury to the cell membrane, I proposed The Grease and Detergent Model in which the cell innards, the cell membrane, and the cement that holds the cells together (the matrix) accumulate “cellular grease” due to insufficient detergents in the body. Cellular grease is composed of cellular waste, molecular debris, rancid fats, sticky sugars, and pulped proteins. The primary detergent in the body is oxygen, with secondary “oxy-detergents,” such as hydrogen peroxide, nitric oxide, hydroxyl radicals, oxygen-activated enzymes, and grease-eating phagocytes

In cellular grease, in scientific terms, rancid fats are oxidized and peroxidized lipids, sticky sugars are glycosylated proteins and lipids, and pulped proteins are cross-linked peptides (chains of amino acids that make up proteins). This is a vast subject which I address in several articles in my Insulin Toxicity Series. Here I point out that cellular grease buildup is caused by toxic foods, toxic environment, and toxic thoughts.

In The Crank-Crank-Shaft Model of Insulin Toxicity, the blood sugar level rises when insulin fails to drive sugar into the cells to be metabolized (“burned”) to produce energy. The pancreas senses the rising blood sugar levels and responds with overproduction of insulin hormone in order to overcome the resistance of cellular grease. This works for sometime. However, excess insulin is fattening, inflaming, and grease-building. So begins the vicious cycle of:

*  More grease,

*  More insulin resistance,

*  Higher blood sugar,

*  More insulin production,

*  Yet more grease,

*  Yet higher blood glucose level,

*  Yet more insulin production, and

*  Yet more grease.

Pregnant women require an additional energy of 300 kcal/day over routine energy intake [2] while the average glucose utilized by a growing fetus at the 3rd trimester reaches approximately to 33 μmol/kg/min [4]. Maternal IR leads to more use of fats than carbohydrates for energy by mother and spares carbohydrates for fetus. Thus, the development of IR serves as a physiological adaptation of the mother to ensure adequate carbohydrate supply for the rapidly growing fetus [4].

As the pregnancy advances to third trimester, insulin sensitivity may gradually decline to 50% of the normal expected value [5]. This decline is reported to be mediated by a number of factors such as increase in the levels of estrogen, progesterone, human placental lactogen (hPL), among other factors [6].

Normally, insulin binding to insulin receptor causes phosphorylation of β-subunit of receptor and it further leads to phosphorylation of Insulin Receptor Substrate-I (IRS-I) at tyrosine residue which act as docking site for further signal transduction molecules [7].

Progesterone suppresses the phosphoinositol 3-kinase-mediated pathway by reducing the expression of IRS-1. Gradually increasing progesterone concentration with advancement of normal pregnancy is associated with increased inhibition insulin-induced GLUT4 translocation and glucose uptake [8]. Estrogen concentration is also high in pregnancy. 17β-estradiol diminishes insulin sensitivity at high concentrations [9].

hPL has both insulin-like and anti-insulin effects. In vitro, it has been shown to increase lipolysis and free fatty acids (FFAs) in adipocytes. Increased hPL level in pregnancy is found to increase glucose uptake, oxidation, and incorporation of glucose into glycogen, which may favor glycogen storage in the mother [10].

Human placental growth hormone (hPGH), a product of the human growth hormone variant gene, is not regulated by growth hormone- releasing hormone (GH-RH) and is secreted tonically rather than in a pulsatile fashion. hPGH has the same affinity for the growth hormone receptor as pituitary GH. The hPGH may also have the same diabetogenic effects as pituitary growth hormone such as hyperinsulinemia, decreased insulin-stimulated glucose uptake and glycogen synthesis, and impairment of the ability of insulin to suppress hepatic gluconeogenesis [10].

Other factors such as increased levels of serum cortisol, Tumor necrosis factor α ( TNF α, ILs etc., can interrupt the insulin signaling pathway and can lead to IR during normal pregnancy [11].

Available literature [1214] suggests that there is a rise in IR in 3rd trimester of pregnancy. However literature is less on the 1st and 2nd trimester. So the present study was undertaken to evaluate the status of IR in different phases of normal pregnancy.

Reversing Diabetes: Four Goals for the Patient, Four for the Physician

Majid Ali, M.D.

The Path Away From Diabetes

Four Steps for the Patient

  1.                                  Love

  2.                                 Oxygen

  3.                                 Prayer

  4.                                 Insulin


Love provides the purpose of reversing diabetes.

Prayer provides the path to that purpose.

Oxygen orchestrates the bodily functions that prevent and reverse diabetes.

Insulin is the master energy hormone for preventing and reversing diabetes.


The Path

The Path to Healing Is the Path to Peace.

The Path to Peace Is the Path to the Spiritual.

The Path to the Spiritual Is the Path Away From the Self.

The Path Away from the Self Is the Path to One’s Own Divinity, to Oneness With Divinity.

The Path to That Oneness Is the Path to Insulin Solutions, and Freedom from Diabetes and Its Suffering.


Four Steps for the Physician

My top four goals for reversing diabetes and clearing insulin toxicity (hyperinsulinism) are the same as they for all other chronic diseases. Specifically, they are:

                                      1. Oxygen signaling  

                                 2. Gut ecology  

                        3. Insulin signaling 

 4. Truth and best effort


For my patients on the Path Away From Diabetes, I 

  • Promise no results,
  • Promise total honesty, and 
  • Promise best effort.


An Important Link for the Path

Other important links for knowing the path, please go to my video library near the end.  

Plant Remedies and Supplements

for Reversing Hyperinsulinism (Prediabetes) and Diabetes

Phytofactors (Plant Remedies) 

  1. Aloe Vera
  2. Bitter melon
  3. Cinnamon
  4. Fenugreek
  5. Flaxseed
  6. Garlic
  7. Ginseng (Panax ginseng)
  8. Gymnema sylvestre
  9. Huckelberry
  10. Neem
  11. Nopal (prickly pear cactus)

Nutritional Supplements

  1. Coenzyme Q10
  2. Chromium
  3. Lipoic acid (alpha lipoic)
  4. Magnesium, potassium, Taurine
  5. Cinnamon
  6. Chromium
  7. Vanadyl sulfate
  8. Multivitamin
  9. Multimineral

Top Priorities for Nutrients and Plant-Based Remedies 

1. Magnesium, Potassium, and Taurine

2. Calcium-magnesium

3  Multiminerals (selenium, chromium, molybdenum, vanadium, manganese),

4. Multivitamins

5. Plant-based remedies


Magnesium, Potassium, and Taurine

I prescribe magnesium, potassium, and taurine for every patients when my goals are:

  1. To reverse diabetes
  2. To clear insulin toxicity of hyperinsulinism
  3.  To prevent complications of Type 2 diabetes
  4. To  alter the course of other types of diabetes.


Magnesium, Do Not Forget To Take It, Please! Majid Ali MD on Vimeo › Majid Ali › Videos

Magnesium, Do Not Forget To Take It, Please! Majid Ali MD. 3 years ago More.Majid AliPRO. Follow. 0 …

How Much Magnesium Do I Take Majid Ali MD on Vimeo › Majid Ali › Videos

How Much Magnesium Do I Take Majid Ali MD. from Majid AliPRO 3 years ago. Follow. 0 0. Download Share …

Magnesium and the Heart – Dr. Ali’s Virtual Medical Library

Magnesium and the Heart. Majid Ali, M.D.. A large body of data showing a relationship between low dietary intake of magnesium and the incidence of cardiac …

Healing Foods by Majid Ali, MD Note: The … Soybean: is an excellent source of minerals such as magnesium, calcium, molybdenum and others. It is rich in …Magnesium and the Heart – Dr. Ali’s Virtual Medical Library

Magnesium and the Heart. Majid Ali, M.D.. A large body of data showing a relationship between low dietary intake of magnesium and the incidence of cardiac …


Magnesium Content of Foods | The Ali Academy Community

Jun 20, 2014 – Magnesium, The Miracle Mineral Majid Ali, M.D. Magnesium is an … I liberally prescribepotassium and magnesium supplementation for all my …

Your Kidney’s New Year Resolution | Renal Health | The Ali Academy …

Dec 29, 2014 – The kidneys help keep the right amount of potassium in the body. … Potassium, Sodium, and Neurotransmission Majid Ali MD – …

Dr. Ali Expains How Minerals Beat Fatigue | The Ali Academy …

Jun 1, 2014 – Minerals: Your Body’s Energy Sparks Majid Ali, M.D. There are two types of … Potassium, Sodium, and Neurotransmission Majid Ali MD – …

How Much Potassium Do I Take Majid Ali MD on Vimeo › Majid Ali › Videos

Join · Log in · Host videos · Compare plans · Professionals · Businesses · Video lovers · Video School …

Dr. Ali’s Spicy Potassium Lemonade – Majid Ali, MD on Vimeo › Majid Ali › Videos

This is “Dr. Ali’s Spicy Potassium Lemonade – Majid Ali, MD” by Majid Ali on Vimeo, the home for high …

Dr. Ali’s Potassium Lemonade – Majid Ali, MD on Vimeo › Majid Ali › Videos
Aug 7, 2014

This is “Dr. Ali’s Potassium Lemonade – Majid Ali, MD” by Majid Ali on Vimeo, the home for high quality …


A free course on Liver Health NOW | Majid Ali MD | The Ali Academy …

Nov 28, 2014 – Inflammation and Liver – Majid Ali, MD ….. methylsulfonylmethane (MSM, 750 to 1,500 mg); taurine (750 to 1,500 mg); and antioxidant vitamins.

Taurine – Majid Ali, MD on Vimeo › Majid Ali › Videos
Apr 23, 2014

Professor Majid Ali shares information about “Taurine

Ali Healing Community

Majid Ali, M.D Misinformation about the science of health, eating depleted … Why do I commonly prescribe magnesium, potassium, and taurine for most of my …

Majid Ali MD | –

Read all of the posts by Majid Ali MD on. … Why do I commonly prescribe magnesium, potassium, andtaurine for most of my patients with chronic disease in my …

Integrated Magnesium Therapy – Who Is Dr. Ali?

Aug 3, 2017 – Majid Ali, M.D. I liberally prescribe integrated magnesium … magnesium prescriptions nearly always include potassium, calcium, and taurine.



Vitamin B6 for Preventing and Reversing Gestational Diabetes

Vitamin B 6 in its Pyridoxal-5-phosphate (P5P) form can be rightfully considered a nutrient of choice for preventing and reversing gestational diabetes. Simply stated, this is how it works:

  1. Xanthourenic acid (XA) is a metabolite of tryptophan(which is used to produced melatonin and serotonin)
  2. Women who are more vulnerable to gestational diabetes seem to have altered enzymatic function so tryptophan is readily turned into xanthourenic but not so readily into melatonin and serotonin.
  3. Excess xanthourenic acid binds with insulin and blocks metabolic functions of insulin in lowering blood glucose level setting the stage for gestational diabetes..
  4. Women who are more vulnerable to gestational diabetes seem to have altered enzymatic function so tryptophan is readily turned into xanthourenic but not so readily into melatonin and serotonin.
  5. Very high estrogen levels during pregnancy also seem to play a role.



Top Priority Nutrients for Reversing Diabetes By Clearing Insulin Toxicity

Majid Ali, M.D.   Top Priorities for Nutrients and Plant-Based Remedies  1. Magnesium, Potassium, and Taurine 2. Calcium-magnesium 3  Multiminerals (selenium, chromium, molybdenum, vanadium, manganese, 4. Multivitamin   …

What Is Empirical Healing?

Majid Ali, M.D. All healing is energy healing. Since humans began to look for ways to deal with illness, it sought therapies that worked and were safe. In earlier times, safe and effective therapies were not discarded ju…

Dr. Ali’s Insulin Library

Majid Ali, M.D. My Oxygen Thinking Has Given Me Insights About the Roles of Insulin in Health and Disease which Robustly Challenge the Prevailing Notions of Insulin, Insulin Resistance, and Hyperinsulinism.    Large Clai…

Not Moving Away From Diabetes Is Moving Towards It

  Majid Ali, M.D. Insulin toxicity and diabetes have eclipsed All Chronic Diseases Worldwide. I am grateful to my Patients (My Truest Teachers) Who Helped Me Recognize This Disturbing Reality.    Insulin Essentials Insul…

Insulin Essentials

Majid Ali, M.D. Very little of What I Learned About Diabetes In Medical School Has Been Validated by My Patients, My True Teachers.   Insulin Essentials Insulin is the master energy hormone of the body, for energy genera…

Reversing Diabetes D3 – Part A: The Diet Plan

Majid Ali, M.D. A Simplified Yet Effective Choices in-the-Kitchen Part of Reversing Diabetes D3 Plan for Preventing and Reversing Diabetes Based on Authentic Science and Philosophy of Holism    Reversing  Diabetes D3    …

Diabetes and Insulin Library

Majid Ali, M.D. A Comprehensive Library of the Science and Philosophy of Holism For Preventing and Reversing Diabetes    Diabetes Reversal With Insulin Detox | Ali Diabetes…
Majid Ali, M.D. Alzheimer’s Disease Before the Supreme Court of Science – 2017     Alzheimer’s Before the Supreme Court of Science – 2017 I have subscribed and read the journal Nature over 25 for years. It is a journal o…
Three Stages of Diabetes
Majid Ali, M.D. Do You Know Which One of the Three Stages of Diabetes You Are In? Why That Is Important?   You can Learn This Only With Blood Insulin Test. Diabetes In Hyperinsulinism Stage With High Blood In…
  • Should A1c Tests Be Used for Screening for Diabetes? No.

Majid Ali, M.D. Insulin and Glucose Profiles of Reversing Diabetes D3 Series     The blood A1c test is an excellent test for monitoring the results of diabetes treatment, but it is not reliable for screening for diabetes…